Copper-based electrodes fabricated by GHz-burst femtosecond laser sintering of copper powders for non-enzymatic D-glucose detection
Source abstract
Abstract
Abstract High-performance porous copper (Cu)-based electrochemical sensors could potentially be achieved using GHz-burst femtosecond laser sintering, which allows enhanced control over the oxidation state and surface area. In this study, porous Cu-based electrodes were fabricated by GHz-burst femtosecond laser sintering and their electrochemical performances were evaluated in the non-enzymatic detection of D-glucose. Electrodes were produced under different intra-pulse numbers ( N int = 1, 2, 5, and 10), allowing control over both the extent of oxidation and the phase composition. At higher intra-pulse numbers, oxidation was effectively suppressed because of the reduced pulse intensity, whereas lower intra-pulse numbers promoted copper(I) oxide (Cu 2 O) formation through excessive heating. Electrochemical studies revealed that the Cu 2 O-containing electrode fabricated in the non-burst mode ( N int = 1) exhibited superior catalytic activity, demonstrating enhanced sensitivity toward D-glucose compared with that achieved using Cu-rich electrodes. These results confirm that GHz-burst femtosecond laser sintering provides precise control over the Cu phases and porosity, offering a promising strategy for developing efficient non-enzymatic glucose sensors.
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Research context
OpenAlex topics: Electrochemical sensors and biosensors · Copper-based nanomaterials and applications · Electrochemical Analysis and Applications
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References (42)
Show source-provided references
1. M.I. Hossain, M.A. Hasnat, Recent advancements in non-enzymatic electrochemical sensor development for the detection of organophosphorus pesticides in food and environment. Heliyon 9, e19299 (2023). https://doi.org/10.1016/j.heliyon.2023.e1929910.1016/j.heliyon.2023.e19299 ↗
2. G.G. Kumar, G. Amala, S.M. Gowtham, Recent advancements, key challenges and solutions in non-enzymatic electrochemical glucose sensors based on graphene platforms. RSC Adv. 7, 36949–36976 (2017). https://doi.org/10.1039/C7RA02845H10.1039/C7RA02845H ↗
3. M. Wei, Y. Qiao, H. Zhao, J. Liang, T. Li, Y. Luo, S. Lu, X. Shi, W. Lu, X. Sun, Electrochemical non-enzymatic glucose sensors: recent progress and perspectives. Chem. Commun. 56, 14553–14569 (2020). https://doi.org/10.1039/D0CC05650B10.1039/D0CC05650B ↗
4. S. Park, H. Boo, T.D. Chung, Electrochemical non-enzymatic glucose sensors. Anal. Chim. Acta 556, 46–57 (2006). https://doi.org/10.1016/j.aca.2005.05.08010.1016/j.aca.2005.05.080 ↗
5. A. Shadlaghani, M. Farzaneh, D. Kinser, R.C. Reid, Direct electrochemical detection of glutamate, acetylcholine, choline, and adenosine using non-enzymatic electrodes. Sensors 19, 447 (2019). https://doi.org/10.3390/s1903044710.3390/s19030447 ↗
6. K. Mahato, T. Saha, S. Ding, S.S. Sandhu, A.-Y. Chang, J. Wang, Hybrid multimodal wearable sensors for comprehensive health monitoring. Nat. Electron. 7, 735–750 (2024). https://doi.org/10.1038/s41928-024-01247-410.1038/s41928-024-01247-4 ↗
7. G. Wang, X. He, L. Wang, A. Gu, Y. Huang, B. Fang, B. Geng, X. Zhang, Non-enzymatic electrochemical sensing of glucose. Microchim. Acta 180, 161–186 (2013). https://doi.org/10.1007/s00604-012-0923-110.1007/s00604-012-0923-1 ↗
8. N. Ermiş, N. Tinkiliç, Development of an electrochemical sensor for selective determination of dopamine based on molecularly imprinted Poly(p-aminothiophenol) polymeric film. Electroanalysis 33, 1491–1501 (2021). https://doi.org/10.1002/elan.20206055610.1002/elan.202060556 ↗
9. A. Gutiérrez, M.G. Ramírez-Ledesma, G.A. Rivas, G. Luna-Bárcenas, R.A. Escalona-Villalpando, J. Ledesma-García, Development of an electrochemical sensor for the quantification of ascorbic acid and acetaminophen in pharmaceutical samples. J. Pharm. Biomed. Anal. 249, 116334 (2024). https://doi.org/10.1016/j.jpba.2024.11633410.1016/j.jpba.2024.116334 ↗
10. F. Sun, L. Li, P. Liu, Y. Lian, Nonenzymatic electrochemical glucose sensor based on novel copper film. Electroanalysis 23, 395–401 (2011). https://doi.org/10.1002/elan.20100039110.1002/elan.201000391 ↗
11. M.A. Mohamed, M. Banks, S.K. Nejad, A. Al-Shami, A. Soleimani, H. Ma, F. Amirghasemi, V. Ong, M.P.S. Mousavi, Low-cost fiber-based electrochemical sensor for quantification of acetaminophen in human breast milk. npj Womens Health 3, 48 (2025). https://doi.org/10.1038/s44294-025-00088-610.1038/s44294-025-00088-6 ↗
12. W.-T. Chiu, T.-F. Chang, M. Sone, H. Hosoda, A.T. Mita, H. Toshiyoshi, A review on metallic nanomaterials for nonenzymatic glucose sensors: from fundamental mechanisms to recently developed nanomaterials. ACS Appl. Nano Mater. 8, 6818–6838 (2025). https://doi.org/10.1021/acsanm.4c0670610.1021/acsanm.4c06706 ↗
13. K. Singh, K.K. Maurya, M. Malviya, Review of electrochemical sensors and biosensors based on first-row transition metals, their oxides, and noble metals nanoparticles. J. Anal. Test. 8, 143–159 (2024). https://doi.org/10.1007/s41664-023-00292-w10.1007/s41664-023-00292-w ↗
14. K.B. Male, S. Hrapovic, Y. Liu, D. Wang, J.H.T. Luong, Electrochemical detection of carbohydrates using copper nanoparticles and carbon nanotubes. Anal. Chim. Acta 516, 35–41 (2004). https://doi.org/10.1016/j.aca.2004.03.07510.1016/j.aca.2004.03.075 ↗
15. W. Liu, G. Chai, X. Zhao, Y. Dai, Y. Qi, Effect of different copper sources on the morphology of cuprous oxide and its application as a non-enzymatic glucose sensor. Sens. Actuators B Chem. 321, 128485 (2020). https://doi.org/10.1016/j.snb.2020.12848510.1016/j.snb.2020.128485 ↗
16. I.I. Tumkin, E.M. Khairullina, M.S. Panov, K. Yoshidomi, M. Mizoshiri, Copper and nickel microsensors produced by selective laser reductive sintering for non-enzymatic glucose detection. Materials 14, 2493 (2021). https://doi.org/10.3390/ma1410249310.3390/ma14102493 ↗
17. R. Feng, Y. Fan, Y. Fang, Y. Xia, Morphological effects of Au nanoparticles on electrochemical sensing platforms for nitrite detection. Molecules 28, 4934 (2023). https://doi.org/10.3390/molecules2813493410.3390/molecules28134934 ↗
18. H.-X. Wu, W.-M. Cao, Y. Li, G. Liu, Y. Wen, H.-F. Yang, S.-P. Yang, In situ growth of copper nanoparticles on multiwalled carbon nanotubes and their application as non-enzymatic glucose sensor materials. Electrochim. Acta 55, 3734–3740 (2010). https://doi.org/10.1016/j.electacta.2010.02.01710.1016/j.electacta.2010.02.017 ↗
19. F.J. Hong, P. Cheng, H.Y. Wu, Z. Sun, Evaporation/boiling heat transfer on capillary feed copper particle sintered porous wick at reduced pressure. Int. J. Heat Mass Transf. 63, 389–400 (2013). https://doi.org/10.1016/j.ijheatmasstransfer.2013.03.08610.1016/j.ijheatmasstransfer.2013.03.086 ↗
20. J. Zhang, J.H. Ma, J. Bai, D. Yang, M. Zhang, Z. Yang, L. Fan, X.L. Chenab, R.G. Guan, A facile template-assisted electrodeposition approach to porous Cu/Cu2O nanowires. RSC Adv. 11, 30215–30221 (2021). https://doi.org/10.1039/D1RA04770A10.1039/D1RA04770A ↗
21. J. Darayen, O. Chailapakul, P. Praserthdam, P. Praserthdam, J. Panpranot, D.N. Tungasmita, Y. Boonyongmaneerat, Porous electrodeposited Cu as a potential electrode for electrochemical reduction reactions of CO2. Appl. Sci. 11, 11104 (2021). https://doi.org/10.3390/app11231110410.3390/app112311104 ↗
22. E.M. Khairullina, K. Ratautas, M.S. Panov, V.S. Andriianov, S. Mickus, A.A. Manshina, G. Račiukaitis, I.I. Tumkin, Laser-assisted surface activation for fabrication of flexible non-enzymatic Cu-based sensors. Microchim. Acta 189, 259 (2022). https://doi.org/10.1007/s00604-022-05347-w10.1007/s00604-022-05347-w ↗
23. M. Mizoshiri, K. Yoshidomi, H. Komatsu, E.M. Khairullina, I. Tumkin, A. Ostendorf, Effect of CuO nanoparticle size distribution on Cu‑based patterns fabricated via femtosecond laser‑pulse‑induced thermochemical reduction. J. Mater. Sci. 59, 21158–21172 (2024). https://doi.org/10.1007/s10853-024-10423-y10.1007/s10853-024-10423-y ↗
24. B. Kang, S. Han, J. Kim, S. Ko, M. Yang, One-step fabrication of copper electrode by laser-induced direct local reduction and agglomeration of copper oxide nanoparticle. J. Phys. Chem. C 115, 23664–23670 (2011). https://doi.org/10.1021/jp205281a10.1021/jp205281a ↗
25. C. Kerse, H. Kalaycıoğlu, P. Elahi, B. Çetin, D.K. Kesim, Ö. Akçaalan, S. Yavaş, M.D. Aşık, B. Öktem, H. Hoogland, R. Holzwarth, F.Ö. Ilday, Ablation-cooled material removal with ultrafast bursts of pulses. Nature 537, 84–88 (2016). https://doi.org/10.1038/nature1861910.1038/nature18619 ↗
26. D. Metzner, P. Lickschat, C. Kreisel, T. Lampke, S. Weißmantel, Study on laser ablation of glass using MHz-to-GHz burst pulses. Appl. Phys. A 128, 637 (2022). https://doi.org/10.1007/s00339-022-05776-710.1007/s00339-022-05776-7 ↗
27. T. Sasahara, T. Tamaki, T. Ota, M. Matsumoto, M. Mizoshiri, Relation between envelope shape of GHz/MHz burst-mode femtosecond laser pulses and laser-processed shapes in copper sintering. Trans. GIGAKU 11, 11007/1-8 (2023). https://doi.org/10.34468/gigaku.11.1_11007-110.34468/gigaku.11.1_11007-1 ↗
28. https://www.aliexpress.us/item/3256807389247926.html?gatewayAdapt=glo2usa#nav-specification
29. Precursor Dependent Structural Phase Evolution in Hydrothermally Prepared Cu2O Octahedrons and Cu Micro-Flakes and Their Structural and Optical Properties. Trans. Indian. Inst. Met. 71, 1185–1191 (2018). https://doi.org/10.1007/s12666-017-1254-z10.1007/s12666-017-1254-z ↗
30. H.Y.H. Chan, C.G. Takoudis, M.J. Weaver, Oxide film formation and oxygen adsorption on Copper in aqueous media as probed by surface-enhanced Raman spectroscopy. J. Phys. Chem. B 103, 357–365 (1999). https://doi.org/10.1021/jp983787c10.1021/jp983787c ↗
31. P. Dawson, M.M. Hargreave, G.R. Wilkinson, The dielectric and lattice vibrational spectrum of cuprous oxide. J. Phys. Chem. Solids 34, 2201–2208 (1973). https://doi.org/10.1016/S0022-3697(73)80067-810.1016/S0022-3697(73)80067-8 ↗
32. A.Z. Genack, H.Z. Cummins, M.A. Washington, A. Compaan, Quadrupole-dipole Raman scattering at the 1S yellow exciton in Cu2O. Phys. Rev. B 12, 2478–2487 (1975). https://doi.org/10.1103/PhysRevB.12.247810.1103/PhysRevB.12.2478 ↗
33. B.I. Cho, T. Ogitsu, K. Engelhorn, A.A. Correa, Y. Ping, J.W. Lee, L.J. Bae, D. Prendergast, R.W. Falcone, P.A. Heimann, Measurement of electron-ion relaxation in warm dense Copper. Sci. Rep. 6, 18843 (2016). https://doi.org/10.1038/srep1884310.1038/srep18843 ↗
34. R. Toida, T. Maruchi, P. Lotfalinezhad, M. Adachi, T. Matsunaga, T. Fujita, K. Hirata, M. Matsunami, T. Takeuchi, Heat flow switching device working with the latent-heat-induced heat-pumping phenomenon. Mater. Trans. 67, 149–156 (2026). https://doi.org/10.2320/matertrans.MT-E202500310.2320/matertrans.MT-E2025003 ↗
35. Y. Shimizu, J. Ishii, K. Shinzato, T. Baba, A novel method for determination of the thermal diffusivity of thin films using a modulated CO2 laser. Int. J. Thermophys. 26, 203–211 (2005). https://doi.org/10.1007/s10765-005-2367-x10.1007/s10765-005-2367-x ↗
36. C. Lu, Z. Li, L. Ren, N. Su, D. Lu, Z. Liu, In situ oxidation of Cu2O crystal for electrochemical detection of glucose. Sensors 19, 2926 (2019). https://doi.org/10.3390/s1913292610.3390/s19132926 ↗
37. K. Cao, H. Zhang, Z. Gao, Y. Liu, Y. Jia, H. Liu, Boosting glucose oxidation by constructing Cu–Cu2O heterostructures. New J. Chem. 44, 18449 (2020). https://doi.org/10.1039/D0NJ03700A10.1039/D0NJ03700A ↗
38. N. Elgrishi, K.J. Rountree, B.D. McCarthy, E.S. Rountree, T.T. Eisenhart, J.L. Dempsey, A practical beginner’s guide to cyclic voltammetry. J. Chem. Educ. 95, 197–206 (2018). https://doi.org/10.1021/acs.jchemed.7b0036110.1021/acs.jchemed.7b00361 ↗
39. L. Wang, J. Fu, H. Hou, Y. Song, A facile strategy to prepare Cu2O/Cu electrode as a sensitive enzyme-free glucose sensor. Int. J. Electrochem. Sci. 7, 12587–12600 (2012) https://doi.org/10.1016/S1452-3981(23)16568-010.1016/S1452-3981(23)16568-0 ↗
40. Z.J. Luo, T.T. Han, L.L. Qu, X.Y. Wu, A ultrasensitive nonenzymatic glucose sensor based on Cu2O polyhedrons modified Cu electrode. Chin. Chem. Lett. 23, 953–956 (2012). https://doi.org/10.1016/j.cclet.2012.06.00310.1016/j.cclet.2012.06.003 ↗
41. K. Cao, H. Zhang, Z. Gao, Y. Liu, Y. Jia, H. Liu, Boosting glucose oxidation by constructing Cu-Cu2O heterostructures. New J. Chem. 44, 18449–18456 (2020). https://doi.org/10.1039/D0NJ03700A10.1039/D0NJ03700A ↗
42. C. Lu, Z. Li, L. Ren, N. Su, D. Lu, Z. Liu, In situ oxidation of Cu2O crystal for electrochemical detection of glucose. Sensors 19, 2926 (2019). https://doi.org/10.3390/s1913292610.3390/s19132926 ↗