journal article·2026-05

Tailoring of sol-gel borate-based bioactive glass doped with magnesium and copper oxides for in vitro response optimization

M. A. Madshal, Norah T. S. Albogamy

Applied Physics A· Volume 132· Issue 5
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Abstract

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OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · Endodontics and Root Canal Treatments

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References (46)

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1. D. Tang, R.S. Tare, L.-Y. Yang, D.F. Williams, K.-L. Ou, R.O. Oreffo, Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration. Biomaterials 83, 363–382 (2016)10.1016/j.biomaterials.2016.01.024 ↗
2. M. Ansari, Bone tissue regeneration: biology, strategies and interface studies. Prog. Biomater. 8(4), 223–237 (2019)10.1007/s40204-019-00125-z ↗
3. Y. Zhu, X. Zhang, G. Chang, S. Deng, H.F. Chan, Bioactive glass in tissue regeneration: unveiling recent advances in regenerative strategies and applications. Adv. Mater. 37(2), 2312964 (2025)10.1002/adma.202312964 ↗
4. H. Madival, A. Rajiv, A comprehensive review of bioactive glasses: synthesis, characterization, and applications in regenerative medicine. Biomedical Mater Devices 1–21 (2025)10.1007/s44174-025-00310-8 ↗
5. M. Madshal, A. Abdelghany, M. Abdelghany, G. El-Damrawi, Fabrication and in vitro studies on bioactive borate glasses containing dopant chromium sulfate. Ceram. Int. 49(19), 31591–31597 (2023)10.1016/j.ceramint.2023.07.111 ↗
6. K.Ö. Güner, A.C. Özarslan, C. Özel, M. Kucak, İT. Kara, S. Yücel, Production, structural characterization and in vitro biological evaluation of a new bioactive glass with the composition of SiO2-Na2O-CaO-P2O5-B2O3-MgO-V2O5. Inorg. Chem. Commun. 177, 114326 (2025)10.1016/j.inoche.2025.114326 ↗
7. P. Satyanarayana, S. Patel, G. Mahar, In-vitro studies of B2O3–Li2O–P2O5–CaO–ZrO2 nano glasses for biomedical applications. Ceram. Int. 51(4), 4572–4579 (2025)10.1016/j.ceramint.2024.11.431 ↗
8. H. Li, L. Ma, Y. Li, Unraveling the synergistic effects of Ag, Li and Sr on Zn alloys in enhancing orthopedic repair potential. J. Mater. Chem. B 13(12), 4006–4019 (2025)10.1039/D5TB00111K ↗
9. B. Kołodziejska, N. Stępień, J. Kolmas, The influence of strontium on bone tissue metabolism and its application in osteoporosis treatment. Int. J. Mol. Sci. 22(12), 6564 (2021)10.3390/ijms22126564 ↗
10. D.L. Perry, A.W. Wren, The effect of copper addition on strontium-containing silicate-based sol-gel bioactive glass for tissue regeneration. J. Non-Cryst. Solids 625, 122761 (2024)10.1016/j.jnoncrysol.2023.122761 ↗
11. C. Wu, J. Chang, Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors. J. Control. Release 193, 282–295 (2014)10.1016/j.jconrel.2014.04.026 ↗
12. A. Obata, S. Lee, T. Kasuga, Bioactive glass materials for tissue regeneration. J. Ceram. Soc. Japan 130(8), 595–604 (2022)10.2109/jcersj2.22054 ↗
13. S.A. Fernando, T.J. Gray, T. Gottlieb, Healthcare-acquired infections: prevention strategies. Intern. Med. J. 47(12), 1341–1351 (2017)10.1111/imj.13642 ↗
14. R. Golovchak et al., Copper strontium phosphate glasses with high antimicrobial efficacy. Sci. Rep. 15(1), 4677 (2025)10.1038/s41598-025-88781-z ↗
15. M.M. Ahmed, A.A. El-Kheshen, M. Moaness, Strontium/copper doped nano-bioactive glass for biomedical applications. Sci. Rep. (2025). https://doi.org/10.1038/s41598-025-27551-310.1038/s41598-025-27551-3 ↗
16. L.-N. Dragomir, C.-D. Ghiţulică, A. Cucuruz, A. Lazar, G. Voicu, S. Dinescu, Bioactive calcium silico-phosphate glasses doped with Mg2 + and/or Zn2+: biocompatibility, bioactivity and antibacterial activity. Antibiotics 14(6), 534 (2025)10.3390/antibiotics14060534 ↗
17. M.B. Taye, Biomedical applications of ion-doped bioactive glass: a review. Appl. Nanosci. 12(12), 3797–3812 (2022)10.1007/s13204-022-02672-7 ↗
18. A. Anand, H. Kaňková, Z. Hájovská, D. Galusek, A.R. Boccaccini, D. Galusková, Bio-response of copper–magnesium co-substituted mesoporous bioactive glass for bone tissue regeneration. J. Mater. Chem. B 12(7), 1875–1891 (2024)10.1039/D3TB01568H ↗
19. A. Anand et al., Influence of copper-strontium co-doping on bioactivity, cytotoxicity and antibacterial activity of mesoporous bioactive glass. Gels 8(11), 743 (2022)10.3390/gels8110743 ↗
20. F. Kermani, S. Mollazadeh Beidokhti, F. Baino, Z. Gholamzadeh-Virany, M. Mozafari, S. Kargozar, Strontium-and cobalt-doped multicomponent mesoporous bioactive glasses (MBGs) for potential use in bone tissue engineering applications. Materials 13(6), 1348 (2020)10.3390/ma13061348 ↗
21. M. Madshal, N.T. Albogamy, Sol-gel synthesis and in-vitro studies of cobalt and strontium co-doped borate bioactive glass ceramics for biomedical applications. J Solgel Sci Technol 1–15 (2025)10.1007/s10971-025-06922-2 ↗
22. E. Martin et al., Design of sol-gel bioactive glasses: towards tailored architecture and ion-supply for bone tissue regeneration. Open Ceramics 17, 100529 (2024)10.1016/j.oceram.2023.100529 ↗
23. H. Madival, A. Rajiv, C. Muniraju, M.S. Reddy, Advancements in bioactive glasses: a comparison of silicate, borate, and phosphate network based materials. Biomedical Mater Devices 1–21 (2025)10.1007/s44174-025-00297-2 ↗
24. M. Madshal, A. Abdelghany, M. Abdelghany, G. El-Damrawi, Biocompatible borate glasses doped with Gd2O3 for biomedical applications. Eur. Phys. J. Plus. 137(9), 1014 (2022)10.1140/epjp/s13360-022-03204-6 ↗
25. S. Magaldi et al., Well diffusion for antifungal susceptibility testing. Int. J. Infect. Dis. 8(1), 39–45 (2004)10.1016/j.ijid.2003.03.002 ↗
26. C. Valgas, S. Souza, E.F. Smânia, A. Smânia Jr., Screening methods to determine antibacterial activity of natural products. Braz. J. Microbiol. 38, 369–380 (2007)10.1590/S1517-83822007000200034 ↗
27. O.D. Abodunrin, K. El Mabrouk, M. Bricha, A review on borate bioactive glasses (BBG): effect of doping elements, degradation, and applications. J. Mater. Chem. B 11(5), 955–973 (2023)10.1039/D2TB02505A ↗
28. Y. Bai et al., Application of bioactive materials for osteogenic function in bone tissue engineering. Small Methods. 8(8), 2301283 (2024)10.1002/smtd.202301283 ↗
29. G.T. El-Bassyouni, H.H. Beherei, K.R. Mohamed, S.H. Kenawy, Fabrication and bioactivity behavior of HA/bioactive glass composites in the presence of calcium hexaboride. Mater. Chem. Phys. 175, 92–99 (2016)10.1016/j.matchemphys.2016.02.072 ↗
30. X.-B. Chen, Y.-C. Li, J. Du Plessis, P.D. Hodgson, C. Wen, Influence of calcium ion deposition on apatite-inducing ability of porous titanium for biomedical applications. Acta Biomater. 5(5), 1808–1820 (2009)10.1016/j.actbio.2009.01.015 ↗
31. L. Mao et al., The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration. Acta Biomater. 61, 217–232 (2017)10.1016/j.actbio.2017.08.015 ↗
32. Y. Yu, X. Li, Q. Ying, Z. Zhang, W. Liu, J. Su, Synergistic effects of shed-derived exosomes, Cu2+, and an injectable hyaluronic acid hydrogel on antibacterial, anti-inflammatory, and osteogenic activity for periodontal bone regeneration. ACS Appl. Mater. Interfaces 16(26), 33053–33069 (2024)10.1021/acsami.4c05062 ↗
33. G. El-Damrawi, A. Abdelghany, M. Abdelghany, M. Madshal, Structural role of chromium sulfate in modified borate glasses and glass ceramics. Materialia 16, 101095 (2021)10.1016/j.mtla.2021.101095 ↗
34. Y.B. Saddeek, Structural and acoustical studies of lead sodium borate glasses. J. Alloys Compd. 467(1–2), 14–21 (2009)10.1016/j.jallcom.2007.11.126 ↗
35. M. Madshal, G. El-Damrawi, A. Abdelghany, M. Abdelghany, Structural studies and physical properties of Gd2O3-doped borate glass. J. Mater. Sci. Mater. Electron. 32(11), 14642–14653 (2021)10.1007/s10854-021-06022-1 ↗
36. A. Abdelghany, R. Ramadan, H. Elbatal, M. Madshal, Structural, optical, and shielding characteristics of CuO diborate glasses containing lithium fluoride or lithium oxide. Results Chem. 7, 101299 (2024)10.1016/j.rechem.2023.101299 ↗
37. A.M. Abdelghany, N.A.M. Alsaif, M.A. Madshal, H.A. ElBatal, Y.S. Rammah, W. Awad, Structural, optical and radiation shielding parameters of sodium aluminium borate glasses modified with chromium oxide. Radiat. Phys. Chem. 207, 110861 (2023). https://doi.org/10.1016/j.radphyschem.2023.11086110.1016/j.radphyschem.2023.110861 ↗
38. S.R. Zainudin, S. Adam, J. Banjuraizah, F. Zainuddin, Sol gel synthesis and preparation of macroporous glass: effect of sodium nitrate addition. Int. J. Curr. Res. Sci. Eng. Technol 1, 1–7 (2018)10.30967/ijcrset.1.S1.2018.1-7 ↗
39. Y.A. Yamusa, R. Hussin, W.N.W. Shamsuri, S.A. Dalhatu, A.M. Aliyu, I. Bulus, Structural characterization of sulphate borophosphate glasses containing calcium oxide. Mal. J. Fund. Appl. Sci. 13(3), 193–197 (2017)10.11113/mjfas.v13n3.666 ↗
40. A. Fayad, M. Abdel-Baki, G.T. El-Bassyouni, M. Farag, M.M. Ahmed, Modifying of physical, biodegradation, drug delivery characteristics of bioactive borophosphate glass by addition of molybdenum. Mater. Chem. Phys. 317, 129115 (2024)10.1016/j.matchemphys.2024.129115 ↗
41. A. Ghneim, L. Abou Samra, D. Schaniel, S. Soule, C. Carteret, E.-E. Bendeif, Multiscale investigation on the formation path of the apatite phase in bioactive glasses. J. Non-Cryst. Solids 639, 123095 (2024). https://doi.org/10.1016/j.jnoncrysol.2024.12309510.1016/j.jnoncrysol.2024.123095 ↗
42. J.M. Tainio, S. Vanhatupa, S. Miettinen, J. Massera, Borosilicate bioactive glasses with added Mg/Sr enhances human adipose-derived stem cells osteogenic commitment and angiogenic properties. J. Mater. Sci. Mater. Med. 35(1), 71 (2024)10.1007/s10856-024-06830-x ↗
43. C. Wu, Y. Zhou, C. Lin, J. Chang, Y. Xiao, Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering. Acta Biomater. 8(10), 3805–3815 (2012)10.1016/j.actbio.2012.06.023 ↗
44. C. Zhang et al., Imperfect hydroxyapatite bioceramics derived from golden pomfret have enhanced osteogenic properties. Sci. Rep. 15(1), 20582 (2025)10.1038/s41598-025-06015-8 ↗
45. G.L. da Silva et al., Bioactive antibacterial borate glass and glass-ceramics. J. Non-cryst. Solids, 595, 121829 (2022). https://doi.org/10.1016/j.jnoncrysol.2022.12182910.1016/j.jnoncrysol.2022.121829 ↗
46. S. Aqdim, M. Naji, A. Chakir, A.E. Bouari, Design, synthesis and structural properties of borate glasses: towards an alkali-free bioactive glass. J. Non-Cryst. Solids 597, 121876 (2022). https://doi.org/10.1016/j.jnoncrysol.2022.12187610.1016/j.jnoncrysol.2022.121876 ↗