Effect of sintering temperature on microstructure of TiZr alloy fabricated via powder metallurgy for biomedical applications
Source abstract
Abstract
With the growing demand for advanced biomaterials, titanium-based alloys have garnered considerable attention, particularly Ti-Zr alloys due to their superior mechanical strength, excellent biocompatibility, and notably, their enhanced corrosion resistance within physiological environments. In this study, a Ti–20 at% Zr alloy was synthesized using the powder metallurgy technique for potential biomedical use. The influence of compaction pressure and sintering temperature on the alloy’s porosity and microstructure was systematically analyzed through X-ray diffraction (XRD) and scanning electron microscopy (SEM). The alloy microstructure predominantly exhibited two distinct phases, denoted as ? and ??. Additionally, crystal lattice parameters, grain size and micro-stresses were calculated using XRD peaks. It was understood that sintering temperature reduces micro-stresses by expanding the grain volume. Furthermore, electrochemical corrosion testing was conducted to evaluate the alloy’s corrosion performance, and in vivo biocompatibility assessments were performed using a rat model. Findings revealed that increasing the compaction pressure and sintering temperature led to a reduction in porosity. Overall, the Ti–20 at% Zr alloy demonstrated promising bioactivity, remarkable biocompatibility, and robust resistance to corrosion, underscoring its suitability for biomedical applications. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Titanium Alloys Microstructure and Properties · Orthopaedic implants and arthroplasty · Advanced materials and composites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (49)
Show source-provided references
1. P.F. Ji, B. Li, B.H. Chen, F. Wang, W. Ma, X.Y. Zhang, M.Z. Ma, R.P. Liu, Effect of Nb addition on the stability and biological corrosion resistance of Ti-Zr alloy passivation films. Corros. Sci. 170, 108696 (2020). https://doi.org/10.1016/j.corsci.2020.10869610.1016/j.corsci.2020.108696 ↗
2. Ö. Çakmak, M. Kaya, Effect of sintering procedure on microstructure and mechanical properties of biomedical TiNbSn alloy produced via powder metallurgy. Appl. Phys. A 127, 561 (2021). https://doi.org/10.1007/s00339-021-04686-810.1007/s00339-021-04686-8 ↗
3. V. Campana, G. Milano, E. Pagano, M. Barba, C. Cicione, G. Salonna, W. Lattanzi, G. Logroscino, Bone substitutes in orthopaedic surgery: from basic science to clinical practice. J. Mater. Sci. Mater. Med. 25, 2445–2461 (2014). https://doi.org/10.1007/s10856-014-5240-210.1007/s10856-014-5240-2 ↗
4. M. Niinomi, D. Kuroda, K.I. Fukunaga, M. Morinaga, Y. Kato, T. Yashiro, A. Suzuki, Corrosion wear fracture of new β type biomedical titanium alloys. Mater. Sci. Eng., A 263, 193–199 (1999). https://doi.org/10.1016/S0921-5093(98)01117-010.1016/S0921-5093(98)01117-0 ↗
5. A. Sotniczuk, D. Kuczyńska-Zemła, P. Kwaśniak, M. Thomas, H. Garbacz, Corrosion behavior of Ti-29Nb-13Ta-4.6Zr and commercially pure Ti under simulated inflammatory conditions–comparative effect of grain refinement and non-toxic β phase stabilizers. Electrochim. Acta. 312, 369–379 (2019). https://doi.org/10.1016/j.electacta.2019.04.15910.1016/j.electacta.2019.04.159 ↗
6. D. Duraccio, F. Mussano, M.G. Faga, Biomaterials for dental implants: current and future trends. J. Mater. Sci. 50, 4779–4812 (2015). https://doi.org/10.1007/s10853-015-9056-310.1007/s10853-015-9056-3 ↗
7. M. Geetha, A.K. Singh, R. Asokamani, A.K. Gogia, Ti based biomaterials, the ultimate choice for orthopaedic implants – a review. Prog. Mater. Sci. 54, 397–425 (2009). https://doi.org/10.1016/j.pmatsci.2008.06.00410.1016/j.pmatsci.2008.06.004 ↗
8. D.R. Correa, F.B. Vicente, T.A. Donato, V.E. Arana-Chavez, M.A. Buzalaf, C.R. Grandini, The effect of the solute on the structure, selected mechanical properties, and biocompatibility of Ti-Zr system alloys for dental applications. Mater. Sci. Eng., C 34, 354–359 (2014). https://doi.org/10.1016/j.msec.2013.09.00810.1016/j.msec.2013.09.008 ↗
9. C. Correa, A. Gil-Santos, J.A. Porro, M. Díaz, J.L. Ocaña, Eigenstrain simulation of residual stresses induced by laser shock processing in a Ti6Al4V hip replacement. Mater. Design. 79, 106–114 (2015). https://doi.org/10.1016/j.matdes.2015.03.03910.1016/j.matdes.2015.03.039 ↗
10. L. Frauchiger, M. Taborelli, P. Descouts, Structural characterization of Ti90Al6V4 alloy and sulphur segregation. Appl. Surf. Sci. 115, 232–242 (1997). https://doi.org/10.1016/S0169-4332(97)00255-210.1016/S0169-4332(97)00255-2 ↗
11. M. Niinomi, M. Nakai, J. Hieda, Development of new metallic alloys for biomedical applications. Acta Biomater. 8, 3888–3903 (2012). https://doi.org/10.1016/j.actbio.2012.06.03710.1016/j.actbio.2012.06.037 ↗
12. C. Pengfei, J. Ran, Z. Fenggang, L. Jianghua, F. Tian, Mechanical properties and corrosion behavior of β-type Ti-Zr-Nb-Mo alloys for biomedical application. J. Alloys Compd. 842, 155693 (2020). https://doi.org/10.1016/j.jallcom.2020.15569310.1016/j.jallcom.2020.155693 ↗
13. J.Y. Rho, T.Y. Tsui, G.M. Pharr, Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials. 18, 1325–1330 (1997). https://doi.org/10.1016/S0142-9612(97)00073-210.1016/S0142-9612(97)00073-2 ↗
14. S. Ozan, J.X. Lin, Y.C. Li, R. Ipek, C.E. Wen, Development of Ti–Nb–Zr alloys with high elastic admissible strain for temporary orthopedic devices. Acta Biomater. 20, 176–187 (2015). https://doi.org/10.1016/j.actbio.2015.03.00910.1016/j.actbio.2015.03.009 ↗
15. R. Kolli, A. Devaraj, A review of metastable beta titanium alloys. Metals 8, 506 (2018). https://doi.org/10.3390/met807050610.3390/met8070506 ↗
16. Y. Li, C. Yang, H. Zhao, S. Qu, X. Li, Y. Li, New developments of Ti-based alloys for biomedical applications. Materials 7, 1709–1800 (2014). https://doi.org/10.3390/ma703170910.3390/ma7031709 ↗
17. J. Gottlow, M. Dard, F. Kjellson, M. Obrecht, L. Sennerby, Evaluation of a new titanium-zirconium dental implant: a Biomechanical and histological comparative study in the mini pig. Clin. Implant Dent. Relat. Res. 14, 538–545 (2012). https://doi.org/10.1111/j.1708-8208.2009.00270.x10.1111/j.1708-8208.2009.00270.x ↗
18. H.C. Hsu, S.C. Wu, Y.C. Sung, W.F. Ho, The structure and mechanical properties of as-cast Zr–Ti alloys. J. Alloys Compd. 488, 279–283 (2009). https://doi.org/10.1016/j.jallcom.2009.08.11110.1016/j.jallcom.2009.08.111 ↗
19. Z. Cai, T. Shafer, I. Watanabe, M. Nunn, T. Okabe, Electrochemical characterization of cast titanium alloys. Biomaterials. 24, 213–218 (2003). https://doi.org/10.1016/S0142-9612(02)00297-510.1016/S0142-9612(02)00297-5 ↗
20. D. Mareci, D. Sutiman, R. Chelariu, F. Leon, S. Curteanu, Evaluation of the corrosion resistance of new ZrTi alloys by experiment and simulation with an adaptive instance-based regression model. Corros. Sci. 73, 106–122 (2013). https://doi.org/10.1016/j.corsci.2013.03.03110.1016/j.corsci.2013.03.031 ↗
21. J. Pengfei, C. Bohan, B. Li, T. Yihao, Z. Guofeng, Z. Xinyu, M. Mingzhen, L. Riping, Influence of Nb addition on microstructural evolution and compression mechanical properties of Ti-Zr alloys. J. Mater. Sci. Technol. 69, 7–14 (2021). https://doi.org/10.1016/j.jmst.2020.06.01710.1016/j.jmst.2020.06.017 ↗
22. B. Wang, W. Ruan, J. Liu, J. Zhang, T. Hailin, Y. Ruan, Microstructure, mechanical properties, and preliminary biocompatibility evaluation of binary Ti–Zr alloys for dental application. J. Biomater. Appl. 33, 766–775 (2019). https://doi.org/10.1177/088532821880452910.1177/0885328218804529 ↗
23. W. Cui, Y. Liu, Fatigue behavior of Ti50Zr alloy for dental implant application. J. Alloys Compd. 793, 212–219 (2019). https://doi.org/10.1016/j.jallcom.2019.04.20210.1016/j.jallcom.2019.04.202 ↗
24. D. Mareci, G. Bolat, R. Chelariu, D. Sutiman, C. Munteanu, The Estimation of corrosion behaviour of ZrTi binary alloys for dental applications using electrochemical techniques. Mater. Chem. Phys. 141, 362–369 (2013). https://doi.org/10.1016/j.matchemphys.2013.05.04810.1016/j.matchemphys.2013.05.048 ↗
25. C.C. Manole, A. Dinischiotu, A. Nica, I.C. Demetrescu, C. Pirvu, Influence of electrospun TiO₂ nanowires on corrosion resistance and cell response of Ti50Zr alloy. Mater. Corros. 69, 1609–1619 (2018). https://doi.org/10.1002/maco.20181004110.1002/maco.201810041 ↗
26. M. Kaya, F. Yakuphanoğlu, E. Elibol, M. Köm, Microstructure characterization and biocompatibility behaviour of TiNbZr alloy fabricated by powder metallurgy. Mater. Res. Express. 6, 106516 (2019). https://doi.org/10.1088/2053-1591/ab4e9f10.1088/2053-1591/ab4e9f ↗
27. A. Yolun, M. Simsek, M. Kaya, E.E. Annac, M. Kom, O. Cakmak, Fabrication, characterization, and in vivo biocompatibility evaluation of titanium-niobium implants. Proc. Inst. Mech. Eng. Part H: J. Eng. Med. 235, 99–108 (2021). https://doi.org/10.1177/095441192096439510.1177/0954411920964395 ↗
28. A. Bansiddhi, T.D. Sargeant, S.I. Stupp, D.C. Dunand, Porous NiTi for bone implants: a review. Acta Biomater. 4, 773–782 (2008). https://doi.org/10.1016/j.actbio.2008.02.00910.1016/j.actbio.2008.02.009 ↗
29. E.M. Karakurt, Y. Huang, M. Kaya, H. Demirtas, A. Acikgoz, G. Demircan, Effect of relative density on microstructure, corrosion resistance and mechanical performance of porous Ti–20Zr alloys fabricated by powder metallurgy. Arab. J. Sci. Eng. 49, 1479–1489 (2024). https://doi.org/10.1007/s13369-023-08624-410.1007/s13369-023-08624-4 ↗
30. N. Taniguchi, S. Fujibayashi, M. Takemoto, K. Sasaki, B. Otsuki, B. Nakamura, T. Matsushita, T. Kokubo, T. Matsuda, Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: an in vivo experiment. Mater. Sci. Eng., C 59, 690–701 (2016). https://doi.org/10.1016/j.msec.2015.10.06910.1016/j.msec.2015.10.069 ↗
31. A.A. Amigó-Mata, M.H. Rodriguez, A.V. Escuder, V.A. Borrás, Development of Ti–Zr alloys by powder metallurgy for biomedical applications. Powder Metall. 65, 31–38 (2022). https://doi.org/10.1080/00325899.2021.197727110.1080/00325899.2021.1977271 ↗
32. W.F. Ho, W.K. Chen, S.C. Wu, H.C. Hsu, Structure, mechanical properties, and grindability of dental Ti–Zr alloys. J. Mater. Science: Mater. Med. 19, 3185–3190 (2008). https://doi.org/10.1007/s10856-008-3489-010.1007/s10856-008-3489-0 ↗
33. M. Takahashi, M. Kikuchi, O. Okuno, Grindability of dental cast Ti–Zr alloys. Mater. Trans. 50, 859–863 (2009). https://doi.org/10.2320/matertrans.M200828210.2320/matertrans.M2008282 ↗
34. M. Sherif, A comparative study on the corrosion of pure titanium and titanium–12% zirconium alloy after different exposure periods of time in sodium chloride solution. AIP Adv. 14, 035314 (2024). https://doi.org/10.1063/5.020583610.1063/5.0205836 ↗
35. M. Hulka, R. Sedlacek, P. Drnková et al., Electrochemical study and mechanical properties of Ti-Zr alloys for biomedical applications. Crystals. 14, 191 (2024). https://doi.org/10.3390/cryst1402019110.3390/cryst14020191 ↗
36. K. Otsu, Y. Wada, T. Osada et al., Microstructure and enhanced strength and ductility of Ti–Zr–O alloys prepared by a laser powder bed fusion process. Mater. Design. 235, 112500 (2024). https://doi.org/10.1016/j.matdes.2023.11250010.1016/j.matdes.2023.112500 ↗
37. Ş.N. Balo, M. Eskil, Thermodynamic and crystallographic properties of gamma radiated shape memory Cu-Al-Be alloy. Appl. Phys. A 127, 633–643 (2021). https://doi.org/10.1007/s00339-021-04538-510.1007/s00339-021-04538-5 ↗
38. D. Banerjee, J.C. Williams, Perspectives on titanium science and technology. Acta Mater. 61, 844–879 (2013). https://doi.org/10.1016/j.actamat.2012.10.04310.1016/j.actamat.2012.10.043 ↗
39. Q. Chen, G.A. Thouas, Metallic implant biomaterials. Mater. Sci. Eng. R Rep. 87, 1–57 (2015). https://doi.org/10.1016/j.mser.2014.10.00110.1016/j.mser.2014.10.001 ↗
40. T. Shiraishi, K. Yubuta, T. Shishido, N. Shinozaki, Elastic properties of as-solidified Ti-Zr binary alloys for biomedical applications. Mater. Trans. 57, 1986–1992 (2016). https://doi.org/10.2320/matertrans.M201616410.2320/matertrans.M2016164 ↗
41. H. Alshammari, A. Al-Fadhalah, M. Al-Ruqeishi, Zr-bearing powder metallurgy binary Ti alloys: fabrication and characterisation. Mater. Charact. 183, 111603 (2022). https://doi.org/10.1016/j.matchar.2021.11160310.1016/j.matchar.2021.111603 ↗
42. I. Matuła, G. Dercz, M. Zubko, J. Maszybrocka, J. Jurek-Suliga, S. Golba, I. Jendrzejewska, Microstructure and porosity evolution of the Ti–35Zr biomedical alloy produced by elemental powder metallurgy. Materials 13, 4539 (2020). https://doi.org/10.3390/ma1320453910.3390/ma13204539 ↗
43. V.V. Sergienko, A.Y. Koptyug, O.V. Pilyaeva et al., Physical and mechanical properties of Ti–Zr–Nb alloys for medical use. Russ. Metall. 2024(1), 59–66 (2024). https://doi.org/10.1134/S003602952401011410.1134/S0036029524010114 ↗
44. Y.L. Hao, S.Y. Sun, R. Yang et al., Effect of Zr and Nb on microstructure and mechanical properties of Ti-based alloys. Mater. Sci. Eng., A 441, 112–118 (2006). https://doi.org/10.1016/j.msea.2006.09.15010.1016/j.msea.2006.09.150 ↗
45. M. Niinomi, T. Hattori, K. Morikawa, H. Kasuga, A. Suzuki, H. Fukui, S. Niwa, Corrosion behavior and cytocompatibility of Ti–Zr alloys for biomedical applications. Acta Biomater. 8, 4063–4073 (2012). https://doi.org/10.1016/j.actbio.2012.06.03710.1016/j.actbio.2012.06.037 ↗
46. M. Abdel-Hady, K. Hinoshita, M. Morinaga, Microstructure, mechanical properties and corrosion behavior of new Ti–Zr–Nb alloys for biomedical applications. Mater. Sci. Eng., A 452–453, 371–379 (2007). https://doi.org/10.1016/j.msea.2006.10.21110.1016/j.msea.2006.10.211 ↗
47. J.M. Calderon-Moreno, C. Vasilescu, S.I. Drob, S. Ivanescu, P. Osiceanu, P. Drob, M. Popa, S. Preda, E. Vasilescu, Microstructural and mechanical properties, surface and electrochemical characterisation of a new Ti–Zr–Nb alloy for implant applications. J. Alloys Compd. 612, 398–410 (2014). https://doi.org/10.1016/j.jallcom.2014.05.01410.1016/j.jallcom.2014.05.014 ↗
48. Van S. Bael, Y.C. Chai, S. Truscello, M. Moesen, G. Kerckhofs, Van H. Oosterwyck, J.P. Kruth, J. Schrooten, The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds. Acta Biomater. 8, 2824–2834 (2012). https://doi.org/10.1016/j.actbio.2012.04.01210.1016/j.actbio.2012.04.012 ↗
49. J. Van Der Stok, O.P. Van Der Jagt, S.A. Yavari, M.F.P. De Haas, J.H. Waarsing, H. Jahr, E.M.M. Van Lieshout, P. Patka, J.A.N. Verhaar, A.A. Zadpoor, H. Weinans, Selective laser melting-produced porous titanium scaffolds regenerate bone in critical size cortical bone defects. J. Orthop. Res. 31, 792–799 (2013). https://doi.org/10.1002/jor.2229310.1002/jor.22293 ↗