journal article·2025-05

Zn Al-layered double hydroxide nanocarriers for 5-Fluorouracil delivery: enhanced therapeutic efficacy against cervical cancer (HeLa Cells)

Bency Mary B, Anchana Devi C, Alison Christina Fernandez, Meera K

Applied Physics A· Volume 131· Issue 5
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OpenAlex topics: Layered Double Hydroxides Synthesis and Applications · Bone Tissue Engineering Materials · Magnesium Oxide Properties and Applications

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References (45)

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1. P. Kumari, B. Ghosh, S. Biswas, Nanocarriers for cancer-targeted drug delivery. J. Drug Target. 24(3), 179–191 (2016). https://doi.org/10.3109/1061186X.2015.105104910.3109/1061186X.2015.1051049 ↗
2. S. Berner, P. Araya, J. Govan, H. Palza, Cu/Al and Cu/Cr based layered double hydroxide nanoparticles as adsorption materials for water treatment. J. Ind. Eng. Chem. 59, 134–140 (2018). https://doi.org/10.1016/j.jiec.2017.10.01610.1016/j.jiec.2017.10.016 ↗
3. M. Kiani, M. Bagherzadeh, A.M. Ghadiri, P. Makvandi, N. Rabiee, Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities. Sci. Rep. 12(1), 9461 (2022). https://doi.org/10.1038/s41598-022-13431-710.1038/s41598-022-13431-7 ↗
4. V.P. Soniya, P.S. Bhindhu, K. Rajalakshmi, Layered double hydroxides: Properties, synthesis and its application in heavy metal remediation of soil. Memory 11, 2277–7695 (2019)
5. B. Saifullah, M.Z.B. Hussein, Inorganic nanolayers: structure, preparation, and biomedical applications. Int. J Nanomed 5609–5633. (2015). https://doi.org/10.2147/IJN.S7233010.2147/IJN.S72330 ↗
6. C. Hochstetter, Untersuchung über die Zusammensetzung einiger Mineralien. J. Prakt. Chem. 27(1), 375–378 (1842). https://doi.org/10.1002/prac.1842027015610.1002/prac.18420270156 ↗
7. W. Feitknecht, M.J.H.C.A. Gerber, Zur Kenntnis der Doppelhydroxyde und basischen Doppelsalze III. Über Magnesium-Aluminiumdoppelhydroxyd. Helvetica Chimica Acta 25(1), 131–137 (1942). https://doi.org/10.1002/hlca.1942025011510.1002/hlca.19420250115 ↗
8. V.A. Shirin, R. Sankar, A.P. Johnson, H.V. Gangadharappa, K. Pramod, Advanced drug delivery applications of layered double hydroxide. J. Control. Release 330, 398–426 (2021). https://doi.org/10.1016/j.jconrel.2020.12.04110.1016/j.jconrel.2020.12.041 ↗
9. S. Kumari, V. Sharma, A. Sharma, A. Sharma, B.J. Singh, and A.K.Sharma, Layered double hydroxides: a gleam on their synthetic routes with biomedical applications. International Journal on Interactive Design and Manufacturing (IJIDeM), pp.1–9 (2023). https://doi.org/10.1007/s12008-023-01333-510.1007/s12008-023-01333-5 ↗
10. X. Bi, H. Zhang, L. Dou, Layered double hydroxide-based nanocarriers for drug delivery. Pharmaceutics 6(2), 298–332 (2014). https://doi.org/10.3390/pharmaceutics602029810.3390/pharmaceutics6020298 ↗
11. W. Jin, S. Ha, J.H. Myung, B.C. Kim, D.H. Park, Ceramic layered double hydroxide nanohybrids for therapeutic applications. J. Korean Ceram. Soc. 57, 597–607 (2020). https://doi.org/10.1007/s43207-020-00090-510.1007/s43207-020-00090-5 ↗
12. A.B. van Kuilenburg, J.G. Maring, Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patients. Pharmacogenomics 14(7), 799–811 (2013). https://doi.org/10.2217/pgs.13.5410.2217/pgs.13.54 ↗
13. N. Zhang, Y. Yin, S.J. Xu, W.S. Chen, 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules 13(8), 1551–1569 (2008). https://doi.org/10.3390/molecules1308155110.3390/molecules13081551 ↗
14. E. Entezar-Almahdi, S. Mohammadi-Samani, L. Tayebi, F. Farjadian, Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer. Int. J. Nanomed. pp. 5445–5458 (2020). https://doi.org/10.2147/IJN.S25770010.2147/IJN.S257700 ↗
15. G. Bozzuto, A. Molinari, Liposomes as nanomedical devices. Int. J. Nanomed. 10, 975–999 (2015). https://doi.org/10.2147/IJN.S6886110.2147/IJN.S68861 ↗
16. P. Kesharwani, V. Gajbhiye, N.K. Jain, Dendrimer as nanocarrier for drug delivery. Prog. Polym. Sci. 37(1), 22–37 (2012). https://doi.org/10.1016/j.progpolymsci.2011.02.00110.1016/j.progpolymsci.2011.02.001 ↗
17. F. Tang, L. Li, D. Chen, Mesoporous silica nanoparticles: Synthesis, biocompatibility, and drug delivery. Adv. Mater. 24(12), 1504–1534 (2012). https://doi.org/10.1002/adma.20110476310.1002/adma.201104763 ↗
18. J.H. Choy, S.Y. Kwak, J.S. Park, Y.J. Jeong, J.C. Yoo, Cellular uptake behavior of [γ-32P] labeled ATP–LDH nanohybrids. J. Mater. Chem. 10(11), 2535–2538 (2000). https://doi.org/10.1039/B004914K10.1039/B004914K ↗
19. F. Li, X. Duan, J. Liu, D.G. Evans, Applications of layered double hydroxides. Chem. Soc. Rev. 35(11), 121–134 (2006). https://doi.org/10.1039/B502666K10.1039/B502666K ↗
20. Z. Gu, A.C. Thomas, Z.P. Xu, J.H. Campbell, G.Q. Lu, In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids. Chem. Mater. 20(11), 3715–3722 (2009). https://doi.org/10.1021/cm800314310.1021/cm8003143 ↗
21. Q. Wang, Y. Zhang, H. Li, D. Zhang, Layered double hydroxide nanocarriers for drug delivery: Structure, performance and application. J. Control. Release 169(3), 193–202 (2013). https://doi.org/10.1016/j.jconrel.2013.04.01710.1016/j.jconrel.2013.04.017 ↗
22. L. Shi, J. Xue, Zn-Al layered double hydroxide as a nanocarrier for controlled delivery of 5-FU. Mater. Sci. Eng., C 98, 772–779 (2019). https://doi.org/10.1016/j.msec.2019.01.06510.1016/j.msec.2019.01.065 ↗
23. L. Yan, S. Gonca, G. Zhu, W. Zhang, X. Chen, Layered double hydroxide nanostructures and nanocomposites for biomedical applications. J. Mater. Chem. B 7(37), 5583–5601 (2019). https://doi.org/10.1039/C9TB01312A10.1039/C9TB01312A ↗
24. H. Hou, Y. Zhao, C. Li, M. Wang, X. Xu, Y. Jin, Single-cell pH imaging and detection for pH profiling and label-free rapid identification of cancer-cells. Sci. Rep. 7(1), 1759 (2017). https://doi.org/10.1038/s41598-017-01956-110.1038/s41598-017-01956-1 ↗
25. M. Bendellaa, P. Lelièvre, J.L. Coll, L. Sancey, A. Deniaud, B. Busser, Roles of zinc in cancers: From altered metabolism to therapeutic applications. Int. J. Cancer 154(1), 7–20 (2024). https://doi.org/10.1002/ijc.3467910.1002/ijc.34679 ↗
26. D. Bhowmik, K. Chiranjib, S. Kumar, A potential medicinal importance of zinc in human health and chronic. Int. J. Pharm. 1(1), 05–11 (2010). (ISSN No: 0976-5263)
27. A. Li, H. Deng, C. Ye, Y. Jiang, Fabrication and characterization of novel ZnAl-layered double hydroxide for the superadsorption of organic contaminants from wastewater. ACS Omega 5(25), 15152–15161 (2020). https://doi.org/10.1021/acsomega.0c0109210.1021/acsomega.0c01092 ↗
28. E.M. Seftel, E. Popovici, M. Mertens, K. De Witte, G. Van Tendeloo, P. Cool, E.F. Vansant, Zn–Al layered double hydroxides: Synthesis, characterization and photocatalytic application. Microporous Mesoporous Mater. 113(1–3), 296–304 (2008). https://doi.org/10.1016/j.micromeso.2007.11.02910.1016/j.micromeso.2007.11.029 ↗
29. A.A.A. Ahmed, Z.A. Talib, M.Z. bin Hussein, Thermal, optical and dielectric properties of Zn–Al layered double hydroxide. Appl. Clay Sci. 56, 68–76 (2012). https://doi.org/10.1016/j.clay.2011.11.02410.1016/j.clay.2011.11.024 ↗
30. T. Mosmann, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65(1–2), 55–63 (1983). https://doi.org/10.1016/0022-1759(83)90303-410.1016/0022-1759(83)90303-4 ↗
31. G. Starukh, O. Rozovik, O. Oranska, Organo/Zn-Al LDH nanocomposites for cationic dye removal from aqueous media. Nanoscale Res. Lett. 11, 1–10 (2016). https://doi.org/10.1186/s11671-016-1402-010.1186/s11671-016-1402-0 ↗
32. I. Fatimah, A. Yahya, R.M. Iqbal, M. Tamyiz, R.A. Doong, S. Sagadevan, W.C. Oh, Enhanced photocatalytic activity of Zn-al layered double hydroxides for methyl violet and peat water photooxidation. Nanomaterials 12(10), 1650 (2022). https://doi.org/10.3390/nano1210165010.3390/nano12101650 ↗
33. M.A. Drezdzon, Synthesis of isopolymetalate-pillared hydrotalcite via organic-anion-pillared precursors. Inorg. Chem. 27(25), 4628–4632 (1988). https://doi.org/10.1021/ic00298a02410.1021/ic00298a024 ↗
34. K. Takehira, T. Kawabata, T. Shishido, K. Murakami, T. Ohi, D. Shoro, M. Honda, K. Takaki, Mechanism of reconstitution of hydrotalcite leading to eggshell-type Ni loading on MgAl mixed oxide. J. Catal. 231(1), 92–104 (2005). https://doi.org/10.1016/j.jcat.2005.01.02510.1016/j.jcat.2005.01.025 ↗
35. H.E. Salman, N.J. Hussein, Synthesis of zinc-aluminum layered double hydroxides and application of adsorption for nitrate from water. In IOP Conference Series: Materials Science and Engineering (Vol. 571, No. 1, p. 012070). IOP Publishing. (2019) https://doi.org/10.1088/1757-899X/571/1/01207010.1088/1757-899X/571/1/012070 ↗
36. K.M. Parida, M. Sahoo, S. Singha, Synthesis and characterization of a Fe (III)-Schiff base complex in a Zn-Al LDH host for cyclohexane oxidation. J. Mol. Catal. A: Chem. 329(1–2), 7–12 (2010). https://doi.org/10.1016/j.molcata.2010.06.01010.1016/j.molcata.2010.06.010 ↗
37. F.Z. Mahjoubi, A. Khalidi, M. Abdennouri, N. Barka, Zn–Al layered double hydroxides intercalated with carbonate, nitrate, chloride and sulphate ions: Synthesis, characterisation and dye removal properties. J. Taibah Univ. Sci. 11(1), 90–100 (2017). https://doi.org/10.1016/j.jtusci.2015.10.00710.1016/j.jtusci.2015.10.007 ↗
38. H.D. Lutz, W. Eckers, H. Haeuseler, OH stretching frequencies of solid hydroxides and of free OH− ions. J. Mol. Struct. 80, 221–224 (1982). https://doi.org/10.1016/0022-2860(82)87236-010.1016/0022-2860(82)87236-0 ↗
39. S. Yin, Y. Chen, C. Li, X. Qiu, Y. Zhang, Y. Li, Er3+-doped ZnAl-LDH with near-infrared emissions used for the delivery and release of 5-fluorouracil in vitro. J. Iran. Chem. Soc. 19(7), 3043–3056 (2022). https://doi.org/10.1007/s13738-022-02513-y10.1007/s13738-022-02513-y ↗
40. L. Jin, Q. Liu, Z. Sun, X. Ni, M. Wei, Preparation of 5-fluorouracil/β-cyclodextrin complex intercalated in layered double hydroxide and the controlled drug release properties. Ind. Eng. Chem. Res. 49(22), 11176–11181 (2010). https://doi.org/10.1021/ie100990z10.1021/ie100990z ↗
41. J. Song, M. Leng, X. Fu, J. Liu, Synthesis and characterization of nanosized zinc aluminate spinel from a novel Zn–Al layered double hydroxide precursor. J. Alloy. Compd. 543, 142–146 (2012). https://doi.org/10.1016/j.jallcom.2012.07.11110.1016/j.jallcom.2012.07.111 ↗
42. Y. Zhang, H. Xu, S. Lu, Preparation and application of layered double hydroxide nanosheets. RSC Adv. 11(39), 24254–24281 (2021). https://doi.org/10.1039/D1RA03289E10.1039/D1RA03289E ↗
43. B.S. Mohanta, R. Das, N. Das, Tungstophosphate Intercalated ZnAl Layered Double Hydroxide for Adsorptive and Visible Light Driven Photocatalytic Decolourisation of Organic Dyes. Catal. Res. 3(4), 1–19 (2023)10.21926/cr.2304025 ↗
44. F. Bellezza, A. Alberani, M. Nocchetti, V. Marsili, A. Cipiciani, Intercalation of 5-fluorouracil into ZnAl hydrotalcite-like nanoparticles: Preparation, characterization and drug release. Appl. Clay Sci. 101, 320–326 (2014). https://doi.org/10.1016/j.clay.2014.08.02210.1016/j.clay.2014.08.022 ↗
45. S. Arabnezhad, H. Mani, P. Gordi, R. Ahmadi, The cytotoxic effects of 5FU on Hek293 and HeLa cells in vitro. Int. J. BioLife Sci. (IJBLS) 1(3), 128–133 (2022). https://doi.org/10.22034/jbs.2022.16244710.22034/jbs.2022.162447 ↗