Processing window for femtosecond laser microsurgery and fluorescence imaging of an arterial tissue hosted in a microfluidic chip
Source abstract
Abstract
We study the exposure limitations of femtosecond laser microsurgery and multiphoton imaging in a microfluidic chip environment, assessing damage thresholds at various interfaces as well as interference from bubble formation in the hosting solution. Both heat accumulation and incubation effects from multipulse laser exposures at 1-MHz repetition rate were evaluated. For demonstration, three microsurgery approaches of laser scribing, percussion drilling and trepanning were applied to arterial walls loaded in vitro in a lab-on-a-chip device. We report that deleterious effects from interface damage and microbubble formation can be avoided to offer laser processing windows for damage-free fluorescence imaging and precise microsurgery of live tissue hosted inside small microfluidic chambers.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Laser Material Processing Techniques · Ocular and Laser Science Research · Photoacoustic and Ultrasonic Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
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1. R.R. Gattass, E. Mazur, Femtosecond laser micromachining in transparent materials. Nat. Photonics 2, 219–225 (2008)10.1038/nphoton.2008.47 ↗
2. C.B. Schaffer, A. Brodeur, E. Mazur, Laser-induced breakdown and damage in bulk transparent materials induced by tightly focused femtosecond laser pulses. Meas. Sci. Technol. 12, 1784 (2001)10.1088/0957-0233/12/11/305 ↗
3. H.-B. Sun, S. Matsuo, H. Misawa, Three-dimensional photonic crystal structures achieved with two-photon-absorption photopolymerization of resin. Appl. Phys. Lett. 74, 786–788 (1999)10.1063/1.123367 ↗
4. Y. Cheng, K. Sugioka, K. Midorikawa, M. Masuda, K. Toyoda, M. Kawachi, K. Shihoyama, Three-dimensional micro-optical components embedded in photosensitive glass by a femtosecond laser. Opt. Lett. 28, 1144–1146 (2003)10.1364/OL.28.001144 ↗
5. A. Vogel, J. Noack, G. Httman, G. Paltauf, Mechanisms of femtosecond laser nanosurgery of cells and tissues. Appl. Phys. B Lasers Opt. 81, 1015–1047 (2005). doi: 10.1007/s00340-005-2036-610.1007/s00340-005-2036-6 ↗
6. A. Heisterkamp, I.Z. Maxwell, E. Mazur, J.M. Underwood, J.A. Nickerson, S. Kumar, D.E. Ingber, Pulse energy dependence of subcellular dissection by femtosecond laser pulses. Opt. Express 13, 3690–3696 (2005)10.1364/OPEX.13.003690 ↗
7. S.K. Gokce, S.X. Guo, N. Ghorashian, W.N. Everett, T. Jarrell, A. Kottek, A.C. Bovik, A. Ben-Yakar, A. Fully, Automated microfluidic femtosecond laser axotomy platform for nerve regeneration studies in C. elegans. PloS One 9(12), e113917 (2014)10.1371/journal.pone.0113917 ↗
8. W.R. Zipfel, R.M. Williams, W.W. Webb, Nonlinear magic: multiphoton microscopy in the biosciences. Nat. Biotechnol. 21, 1369–1377 (2003)10.1038/nbt899 ↗
9. J.M. Squirrell, D.L. Wokosin, J.G. White, B.D. Bavister, Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability. Nat. Biotechnol. 17, 763–767 (1999)10.1038/11698 ↗
10. D.W. Piston, M.S. Kirby, H. Cheng, W.J. Lederer, W.W. Webb, Two-photon-excitation fluorescence imaging of three-dimensional calcium-ion activity. Appl. Opt. 33, 662–669 (1994)10.1364/AO.33.000662 ↗
11. K. Svoboda, W. Denk, W.H. Knox, S. Tsuda, Two-photon-excitation scanning microscopy of living neurons with a saturable Bragg reflector mode-locked diode-pumped Cr:LiSrAlFl laser. Opt. Lett. 21, 1411–1413 (1996)10.1364/OL.21.001411 ↗
12. D.M. McDonald, P.L. Choyke, Imaging of angiogenesis: from microscope to clinic. Nat. Med. 9, 713–725 (2003)10.1038/nm0603-713 ↗
13. I. Maxwell, S. Chung, E. Mazur, Nanoprocessing of subcellular targets using femtosecond laser pulses. Med. Laser Appl. 20, 193–200 (2005)10.1016/j.mla.2005.07.005 ↗
14. S.I.C.O. Santos, M. Mathew, P. Loza-Alvarez, Real time imaging of femtosecond laser induced nano-neurosurgery dynamics in c. elegans. Opt. Express 18, 364–377 (2010)10.1364/OE.18.000364 ↗
15. N. Nishimura, C.B. Schaffer, D. Kleinfeld, In vivo manipulation of biological systems with femtosecond laser pulses, in SPIE, vol. 6261 (2006), p. 62611J10.1117/12.668886 ↗
16. T. Kaji, S. Ito, H. Miyasaka, Y. Hosokawa, H. Masuhara, C. Shukunami, Y. Hiraki, Nondestructive micropatterning of living animal cells using focused femtosecond laser-induced impulsive force. Appl. Phys. Lett. 91, 023904 (2007)10.1063/1.2753103 ↗
17. T. Juhasz, F. Loesel, R. Kurtz, C. Horvath, J. Bille, G. Mourou, Corneal refractive surgery with femtosecond lasers. IEEE J. Sel. Top. Quantum Electron. 5, 902–910 (1999)10.1109/2944.796309 ↗
18. N. Nishimura, C.B. Schaffer, B. Friedman, P.S. Tsai, P.D. Lyden, D. Kleinfeld, Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat. Methods 3, 99–108 (2006)10.1038/nmeth844 ↗
19. F. Bourgeois, A. Ben-Yakar, Femtosecond laser nanoaxotomy properties and their effect on axonal recovery in C. elegans. Opt. Express 15, 8521–8531 (2007)10.1364/OE.15.008521 ↗
20. K. Isobe , W. Watanabe, K. Itoh, Functional Imaging by Controlled Nonlinear Optical Phenomena (Wiley, New Jersey, 2014)
21. A. Ben-Yakar, F. Bourgeois, Ultrafast laser nanosurgery in microfluidics for genome-wide screenings. Curr. Opin. Biotechnol. 20, 100–105 (2009)10.1016/j.copbio.2009.01.008 ↗
22. D. Huh, B.D. Matthews, A. Mammoto, M. Montoya-Zavala, H.Y. Hsin, D.E. Ingber, Reconstituting organ-level lung functions on a chip. Science 328, 1662–1668 (2010)10.1126/science.1188302 ↗
23. P.A. Quinto-Su, H.-H. Lai, H.H. Yoon, C.E. Sims, N.L. Allbritton, V. Venugopalan, Examination of laser microbeam cell lysis in a pdms microfluidic channel using time-resolved imaging. Lab Chip 8, 408–414 (2008)10.1039/b715708h ↗
24. A. Gunther, S. Yasotharan, A. Vagaon, C. Lochovsky, S. Pinto, J. Yang, C. Lau, J. Voigtlaender-Bolz, S.-S. Bolz, A microfluidic platform for probing small artery structure and function. Lab Chip 10, 2341–2349 (2010)10.1039/c004675b ↗
25. S.E. Hulme, S.S. Shevkoplyas, A. Samuel, Microfluidics: streamlining discovery in worm biology. Nat. Methods 5, 589–590 (2008)10.1038/nmeth0708-589 ↗
26. C. Samara, C.B. Rohde, C.L. Gilleland, S. Norton, S.J. Haggarty, M.F. Yanik, Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration. Proceedings of the National Academy of Sciences of the United States of America 107, 18342–18347 (2010)10.1073/pnas.1005372107 ↗
27. S.X. Guo, F. Bourgeois, T. Chokshi, N.J. Durr, M.A. Hilliard, N. Chronis, A. Ben-Yakar, Femtosecond laser nanoaxotomy lab-on-a- chip for in vivo nerve regeneration studies. Nat. Methods 5, 531–533 (2008)10.1038/nmeth.1203 ↗
28. M. Lenzner, J. Krger, W. Kautek, F. Krausz, Incubation of laser ablation in fused silica with 5-fs pulses. Appl. Phys. A Mater. Sci. Process. 69, 465–466 (1999). doi: 10.1007/s00339005103410.1007/s003390051034 ↗
29. Y. Jee, M.F. Becker, R.M. Walser, Laser-induced damage on single-crystal metal surfaces. J. Opt. Soc. Am. B 5, 648 (1988)10.1364/JOSAB.5.000648 ↗
30. P.R. Herman, A. Oettl, K.P. Chen, R.S. Marjoribanks, laser micromachining of transparent fused silica with 1-ps pulses and pulse trains, in SPIE, vol. 3616 (1999) pp. 148–155
31. S. Eaton, H. Zhang, P. Herman, F. Yoshino, L. Shah, J. Bovatsek, A. Arai, Heat accumulation effects in femtosecond laser-written waveguides with variable repetition rate. Opt. Express 13, 4708–4716 (2005)10.1364/OPEX.13.004708 ↗
32. S.M. Eaton, H. Zhang, M.L. Ng, J. Li, W.-J. Chen, S. Ho, P.R. Herman, Transition from thermal diffusion to heat accumulation in high repetition rate femtosecond laser writing of buried optical waveguides. Opt. Express 16, 9443–9458 (2008)10.1364/OE.16.009443 ↗
33. C. Schaffer, J. Garca, E. Mazur, Bulk heating of transparent materials using a high-repetition-rate femtosecond laser. Appl. Phys. A Mater. Sci. Process. 76, 351–354 (2003). doi: 10.1007/s00339-002-1819-410.1007/s00339-002-1819-4 ↗
34. P.R. Herman, D.J. Moore, Vacuum ultraviolet laser ablation of teflon (ptfe). Mater. Res. Soc. Symp. Proc. 285, 163–168 (1993)10.1557/PROC-285-163 ↗
35. A. Vogel, N. Linz, S. Freidank, G. Paltauf, Femtosecond-laser-induced nanocavitation in water: implications for optical breakdown threshold and cell surgery. Phys. Rev. Lett. 100, 038102 (2008)10.1103/PhysRevLett.100.038102 ↗
36. H. Huang, Z. Guo, Ultra-short pulsed laser pdms thin-layer separation and micro-fabrication. J. Micromech. Microeng. 19, 055007 (2009)10.1088/0960-1317/19/5/055007 ↗
37. C.B. Schaffer, N. Nishimura, E. Mazur, Thresholds for femtosecond laser-induced breakdown in bulk transparent solids and water, in SPIE, vol. 3451 (1998), pp. 2–8
38. T. Lee, D. Jang, D. Ahn, D. Kim, Effect of liquid environment on laser-induced backside wet etching of fused silica. J. Appl. Phys. 107, 033112 (2010)10.1063/1.3294615 ↗