Neodymium (III)-containing poly(lactide-co-glycolide)-coated robocast bioactive glass scaffolds for photothermal therapy and bone regeneration
Source abstract
Abstract
Abstract In this study, trivalent neodymium-doped silicate-based 13–93 bioactive glass scaffolds were prepared by the robocasting method using sol-gel-derived bioactive glass powders for tissue engineering applications. Sintered scaffolds were coated by borate-based 13-93B3 bioactive glass-containing polylactide-co-glycolide solution. The produced composite scaffolds’ mechanical, morphological, and structural characteristics were thoroughly examined, as their in vitro bioactivity in cell culture media and simulated body fluid. Furthermore, the scaffolds’ amoxicillin adsorption and release behavior was examined over time. The outcomes demonstrated that it was feasible to effectively create periodic, mesh-like-patterned robocast glass scaffolds utilizing Nd3+-doped sol-gel-derived bioactive glass powders. The scaffolds’ compressive strengths ranged from 10.02 MPa to 18.6 MPa, with the PLGA-coated scaffolds exhibiting the highest strength values. All of the scaffolds that were submerged in simulated body fluid for 28 days showed hydroxyapatite formation. The presence of borate glass on the surface of the silicate-based glass scaffolds improved the hydroxyapatite formation ability. The quantity of drug adsorption for all types of scaffolds was measured to be between 4 and 9% whereas the cumulative drug release was in the range of 58 to 96%. Borate glass particle-containing PLGA coating enhanced the drug delivery behavior.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Facial Trauma and Fracture Management · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (58)
Show source-provided references
1. L.L. Hench, R.J. Splinter, W.C. Allen, T.K. Greenlee, Bonding mechanism at the interface of ceramic prosthetic materials. J. Biomed. Mater. Res. 2, 117–141 (1971). https://doi.org/10.1002/jbm.82005061110.1002/jbm.820050611 ↗
2. L.L. Hench, The story of bioglass®. J. Mater. Sci. Mater. Med. 17, 967–978 (2006). https://doi.org/10.1007/s10856-006-0432-z10.1007/s10856-006-0432-z ↗
3. J.R. Jones, Review of bioactive glass: from Hench to hybrids. Acta Biomater. 9(1), 4457–4486 (2013). https://doi.org/10.1016/j.actbio.2012.08.02310.1016/j.actbio.2012.08.023 ↗
4. M.N. Rahaman, D.E. Day, B.S. Bal, Q. Fu, S.B. Jung, L.F. Bonewald, A.P. Tomsia, Bioactive glass in tissue engineering. Acta Biomater. 7(6), 2355–2373 (2011). https://doi.org/10.1016/j.actbio.2011.03.01610.1016/j.actbio.2011.03.016 ↗
5. A. Hoppe, N.S. Güldal, A.R. Boccaccini, A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. 32, 2757–2774 (2011). https://doi.org/10.1016/j.biomaterials.2011.01.00410.1016/j.biomaterials.2011.01.004 ↗
6. B.A.E. Ben-Arfa, I.E. Palamá, I.M. Miranda Salvado, J.M.F. Ferreira, R.C. Pullar, Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: the complex interplay between additive ions revealed. J. Biomed. Mater. Res. 107A, 2680–2693 (2019). https://doi.org/10.1002/jbm.a.3677210.1002/jbm.a.36772 ↗
7. A. Baranowska, M. Kochanowicz, A. Wajda, M. Leśniak, J. Żmojda, P. Miluski, I. Zgłobicka, K.J. Kurzydłowski, D. Dorosz, Luminescence sensing method for degradation analysis of bioactive glass fibers. Sensors. 21(6), 2054 (2021). https://doi.org/10.3390/s2106205410.3390/s21062054 ↗
8. M. Wang, G. Pi, Bo. Lei, Europium Doped Monodispersed Bioactive Glass nanoparticles regulate the osteogenic differentiation of human marrow mesenchymal stem cells. J. Biomed. Nanotechnol. 14, 756–764 (2018). https://doi.org/10.1166/jbn.2018.250410.1166/jbn.2018.2504 ↗
9. A.M. Deliormanlı, S.A.M. Issa, M.S. Al-Buriahi et al., Erbium (III)- and terbium (III)-containing silicate-based bioactive glass powders: physical, structural and nuclear radiation shielding characteristics. Appl. Phys. A 127, 463 (2021). https://doi.org/10.1007/s00339-021-04615-510.1007/s00339-021-04615-5 ↗
10. A.M. Deliormanlı, R. Konyalı, Bioactive glass/hydroxyapatite- containing electrospun poly (ε-Caprolactone) composite nanofibers for bone tissue engineering. J. Aust Ceram. Soc. 55, 247–256 (2019). https://doi.org/10.1007/s41779-018-0229-910.1007/s41779-018-0229-9 ↗
11. A.M. Deliormanlı, B. Rahman, S. Oğuzlar, M. Zeyrek, Ongun, Investigation of the structural, photoluminescence properties, bioactivity and 5-fluorouracil delivery behavior of Dy3+ and Dy:Eu3+-doped bioactive glasses. J. Alloys Compd. 944, 169153 (2023). https://doi.org/10.1016/j.jallcom.2023.16915310.1016/j.jallcom.2023.169153 ↗
12. A.M. Deliormanlı, S. Oğuzlar, M. Zeyrek Ongun, Effects of Eu3+, Gd3+ and Yb3+ substitution on the structural, photoluminescence, and decay properties of silicate-based bioactive glass powders. J. Mater. Res. 37, 622–635 (2022). https://doi.org/10.1557/s43578-021-00461-610.1557/s43578-021-00461-6 ↗
13. A.M. Deliormanlı, S. Oguzlar, K. Ertekin, Photoluminescence and decay characteristics of cerium, gallium and vanadium - containing borate-based bioactive glass powders for bioimaging applications. Ceram. Int. 47(3), 3797–3807 (2021). https://doi.org/10.1016/j.ceramint.2020.09.23710.1016/j.ceramint.2020.09.237 ↗
14. J.H.L. Voncken, The Rare Earth elements: an introduction. Springer Cham. 127, 2191–5369 (2016). https://doi.org/10.1007/978-3-319-26809-510.1007/978-3-319-26809-5 ↗
15. B. del Rosal, U. Rocha, E.C. Ximendes, E. Martín Rodríguez, D. Jaque, García Solé, Nd3+ ions in nanomedicine: perspectives and applications. Opt. Mater. 63, 185–196 (2017). https://doi.org/10.1016/j.optmat.2016.06.00410.1016/j.optmat.2016.06.004 ↗
16. U. Rocha, K.U. Kumar, C. Jacinto, I. Villa, F. Sanz-Rodríguez, M. del Carmen Iglesias de la Cruz, A. Juarranz, E. Carrasco, F.C.J.M. van Veggel, E. Bovero, J.G. Solé, D. Jaque, Neodymium-doped LaF3 nanoparticles for fluorescence bioimaging in the second biological window. Small. 10, 1141–1154 (2014). https://doi.org/10.1002/smll.20130171610.1002/smll.201301716 ↗
17. X. Wang, Q. Liu, Y. Bu, C.-S. Liu, T. Liu, X. Yan, Optical temperature sensing of rare-earth ion doped phosphors. RSC Adv. 5, 86219–86236 (2015). https://doi.org/10.1039/C5RA16986K10.1039/C5RA16986K ↗
18. S. K.Semwal, Bhatt, Study of Nd3+ ion as a Dopant in YAG and Glass Laser. Int. J. Phys. 1, 15–21 (2013)
19. A. Bednarkiewicz, D. Wawrzynczyk, M. Nyk, W. Strek, Optically stimulated heating using Nd3+ doped NaYF4 colloidal near infrared nanophosphors. Appl. Phys. B 103, 847–852 (2011). https://doi.org/10.1007/s00340-010-4300-710.1007/s00340-010-4300-7 ↗
20. S.A. de Oliveira, R. Borges, D. Dos Santos Rosa, A.C.S. de Souza, A.B. Seabra, F. Baino, Marchi, Strategies for cancer treatment based on photonic nanomedicine. Mater. (Basel). 14(6), 1435 (2021). https://doi.org/10.3390/ma1406143510.3390/ma14061435 ↗
21. U. Rocha, K. Upendra Kumar, C. Jacinto, J. Ramiro, A.J. Caamaño, J. García Solé, Jaque, Nd3+ doped LaF3 nanoparticles as self-monitored photo-thermal agents. Appl. Phys. Lett. 104, 053703 (2014). https://doi.org/10.1063/1.486296810.1063/1.4862968 ↗
22. M. Quintanilla, A. Benayas, R. Naccache, F. Vetrone, Chap. 5, luminescent nanothermometry with lanthanide-doped nanoparticles, thermometry at the nanoscale: techniques and selected applications. R Soc. Chem. 124–166 (2016)10.1039/9781782622031-00124 ↗
23. N.N. Yusof, S.K. Ghoshal, M.F. Omar, Modified absorption attributes of neodymium doped magnesium-zinc-sulfophosphate glass. Malaysian J. Fundamental Appl. Sci. 13(3), 258–262 (2017). https://doi.org/10.11113/mjfas.v13n3.56110.11113/mjfas.v13n3.561 ↗
24. Z. Yu, Y. He, T. Schomann, K. Wu, Y. Hao, E. Suidgeest, H. Zhang, C. Eich, L.J. Cruz, Rare-earth-metal (Nd3+, Ce3+ and Gd3+)-doped CaF2: nanoparticles for multimodal imaging in biomedical applications. Pharmaceutics. 14(12), 2796 (2022). https://doi.org/10.3390/pharmaceutics1412279610.3390/pharmaceutics14122796 ↗
25. S. Rehman, M.A. Ansari, M.A. Alzohairy, M.N. Alomary, B.R. Jermy, R. Shahzad, N. Tashkandi, Z.H. Alsalem, Antibacterial and antifungal activity of novel synthesized neodymium-substituted cobalt ferrite nanoparticles for biomedical applications. Processes. 7(10), 714 (2019). https://doi.org/10.3390/pr710071410.3390/pr7100714 ↗
26. S.M. El-Bashir, Physical properties Nd3+ doped (SiO2–TiO2) monolithic glass for photoresistor applications. Mater. Res. Express. 4(11), 115203 (2017). https://doi.org/10.1088/2053-1591/aa97a710.1088/2053-1591/aa97a7 ↗
27. L. Ma, Y. Zhou, Z. Zhang, Y. Liu, D. Zhai, H. Zhuang, Q. Li, J. Yuye, C. Wu, J. Chang, Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair. Sci. Adv. 6, 32 (2020). https://doi.org/10.1126/sciadv.abb131110.1126/sciadv.abb1311 ↗
28. A.M. Deliormanlı, A.M. Yıldırım, Sol-gel synthesis of 13–93 bioactive glass powders containing therapeutic agents. J. Aust Ceram. Soc. 52(2), 9–19 (2016)
29. A.M. Deliormanlı, M. Türk, Flow behavior and drug release study of injectable Pluronic F-127 hydrogels containing bioactive glass and carbon-based nanopowders. J. Inorg. Organomet. Polym. 30, 1184–1196 (2020). https://doi.org/10.1007/s10904-019-01346-210.1007/s10904-019-01346-2 ↗
30. A. Sakar-Deliormanlı, E. Çelik, M. Polat, Adsorption of anionic polyelectrolyte and comb polymers onto lead magnesium niobate. Colloids Surf. A, 316(1–3), 202–209 (2008). https://doi.org/10.1016/j.colsurfa.2007.09.00410.1016/j.colsurfa.2007.09.004 ↗
31. T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 27(15), 2907–2915 (2006). https://doi.org/10.1016/j.biomaterials.2006.01.01710.1016/j.biomaterials.2006.01.017 ↗
32. T. Yao, Y. Asayama, Animal-cell culture media: history, characteristics, and current issues. Reprod. Med. Biol. 16(2), 99–117 (2017). https://doi.org/10.1002/rmb2.1202410.1002/rmb2.12024 ↗
33. G. Binson, C. Grignon, G. Le Moal, P. Lazaro, J. Lelong, F. Roblot et al., Overcoming stability challenges during continuous intravenous administration of high-dose Amoxicillin using portable elastomeric pumps. PLoS ONE. 14(8), e0221391 (2019). https://doi.org/10.1371/journal.pone.022139110.1371/journal.pone.0221391 ↗
34. C.B. Landersdorfer, M. Kinzig, J.B. Bulitta, F.F. Hennig, U. Holzgrabe, F. Sörgel, J. Gusinde, Bone penetration of Amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation. Antimicrob. Agents Chemother. 53(6), 2569–2578 (2009). https://doi.org/10.1128/AAC.01119-0810.1128/AAC.01119-08 ↗
35. N.W. Cortés-Penfield, P.A. Kulkarni, The history of antibiotic treatment of osteomyelitis. Open. Forum Infect. Dis. 6(5), ofz181 (2019). https://doi.org/10.1093/ofid/ofz18110.1093/ofid/ofz181 ↗
36. R. Karaman, in From conventinal prodrugs to prodrugs designed by molecular orbital methods, ed. by Zaheer-ul-Haq, J. D. Madura. Frontiers in Computational Chemistry, Chapter 5 (Bentham Science Publishers, 2015), pp. 187–249. https://doi.org/10.2174/978160805978211502000710.2174/9781608059782115020007 ↗
37. M. Luciano Bruschi, 5 - Mathematical models of drug release, strategies to modify the drug release from pharmaceutical systems,Woodhead Publishing, 63–86 (2015), https://doi.org/10.1016/B978-0-08-100092-2.00005-910.1016/B978-0-08-100092-2.00005-9 ↗
38. C.C. Zhang, X. Gao, B. Yilmaz, Development of FTIR spectroscopy methodology for characterization of boron species in FCC catalysts. Catalysts. 10(11), 1327 (2020). https://doi.org/10.3390/catal1011132710.3390/catal10111327 ↗
39. A.M. Deliormanlı, H. Atmaca, Effect of pore architecture on the mesenchymal stem cell responses to graphene/polycaprolactone scaffolds prepared by solvent casting and robocasting. J. Porous Mater. 27, 49–61 (2020). https://doi.org/10.1007/s10934-019-00791-110.1007/s10934-019-00791-1 ↗
40. A.M. Efimov, V.G. Pogareva, IR absorption spectra of vitreous silica and silicate glasses: the nature of bands in the 1300 to 5000 cm-1 region. Chem. Geol. 229, 198–217 (2006). https://doi.org/10.1016/j.chemgeo.2006.01.02210.1016/j.chemgeo.2006.01.022 ↗
41. W.R. Taylor, Application of infrared spectroscopy to studies of silicate glass structure: Examples from the melilite glasses and the systems Na2O-SiO2 and Na2O-Al2O3-SiO2, Proc. Indian Acad. Sci. (Earth Planet. Sci.), 99(1), 99–117 (1990)10.1007/BF02871899 ↗
42. M. Trivedi, A. Branton, D. Trivedi, G. Nayak, K. Bairwa, Spectroscopic characterization of disodium hydrogen orthophosphate and sodium nitrate after biofield treatment. J. Chromatogr. Sep. Tech. 6(5), 282 (2015). https://doi.org/10.4172/2157-7064.100028210.4172/2157-7064.1000282 ↗
43. C.E. Misch, Z. Qu, M.W. Bidez, Mechanical properties of trabecular bone in the human mandible: implications for dental implant treatment planning and surgical placement. J. Oral Maxillofac. Surg. 57(6), 700–708 (1999). https://doi.org/10.1016/s0278-2391(99)90437-810.1016/s0278-2391(99)90437-8 ↗
44. L. Zhao, C. Wu, K. Lin, J. Chang, The effect of poly(lactic-co-glycolic acid) (PLGA) coating on the mechanical, biodegradable, bioactive properties and drug release of porous calcium silicate scaffolds. Biomed. Mater. Eng. 22, 289–300 (2012). https://doi.org/10.3233/BME-2012-071910.3233/BME-2012-0719 ↗
45. A.M. Deliormanlı, M. Ensoylu, G. ALMisned, H.O. Tekin, Two-dimensional molybdenum disulfide/polymer-coated bioactive glass scaffolds for tissue engineering: Fabrication, structural, mechanical, bioactivity, and radiation interaction properties. Ceram Int. 49, Part A, 22861–22874 (2023). https://doi.org/10.1016/j.ceramint.2023.04.11010.1016/j.ceramint.2023.04.110 ↗
46. Y. Kang, A. Scully, D.A. Young, S. Kim, H. Tsao, M. Sen, Y. Yang, Enhanced mechanical performance and biological evaluation of a PLGA coated β-TCP composite scaffold for load-bearing applications. Eur. Polym. J. 47(8), 1569–1577 (2011). https://doi.org/10.1016/j.eurpolymj.2011.05.00410.1016/j.eurpolymj.2011.05.004 ↗
47. O.H. Andersson, K.H. Karlsson, K. Kangasniemi, Calcium phosphate formation at the surface of bioactive glass in vivo. J. Non Cryst. Solids. 119, 290–296 (1990). https://doi.org/10.1016/0022-3093(90)90301-210.1016/0022-3093(90)90301-2 ↗
48. G.A. Stanciu, I. Sandulescu, B. Savu, S.G. Stanciu, K.M. Paraskevopoulos et al., Investigation of the Hydroxyapatite Growth on Bioactive Glass Surface. J. Biomedical Pharm. Eng. 1(1), 34–39 (2007)
49. L. Berzina-Cimdina, N. Borodajenko, Research of Calcium Phosphates Using Fourier Transform Infrared Spectroscopy, Infrared Spectroscopy - Materials Science, Engineering and Technology, Theophanides Theophile (Ed.), 2012, ISBN: 978-953-51-0537-410.5772/36942 ↗
50. A. Nommeots-Nomm, L. Hupa, D. Rohanová, D.S. Brauer, A review of acellular immersion tests on bioactive glasses––influence of medium on ion release and apatite formation. Int. J. Appl. Glass Sci. 11, 537–551 (2020). https://doi.org/10.1111/ijag.1500610.1111/ijag.15006 ↗
51. P. Sepulveda, J.R. Jones, L.L. Hench, In vitro dissolution of melt-derived 45S5 and sol-gel derived 58S bioactive glasses. J. Biomed. Mater. Res. 61(2), 301–311 (2002). https://doi.org/10.1002/jbm.1020710.1002/jbm.10207 ↗
52. G. Lopes da Silva, I.F. Rodrigues, S.S. Silva Pereira, G.M. Gomes Fontoura, A. Silva Reis, F. Pedrochi, A. Steimacher, Bioactive antibacterial borate glass and glass-ceramics. J. Non-cryst. Solids. 595, 121829 (2022). https://doi.org/10.1016/j.jnoncrysol.2022.12182910.1016/j.jnoncrysol.2022.121829 ↗
53. R.F. Brown, M.N. Rahaman, A.B. Dwilewicz, W. Huang, D.E. Day, Y. Li, B.S. Bal, Effect of borate glass composition on its conversion to hydroxyapatite and on the proliferation of MC3T3-E1 cells. J. Biomed. Mater. Res. Part. A 88, 392–400 (2009). https://doi.org/10.1002/jbm.a.3167910.1002/jbm.a.31679 ↗
54. Z. Zhuang, H. Yamamoto, M. Aizawa, Synthesis of plate-shaped hydroxyapatite via an enzyme reaction of urea with urease and its characterization. Powder Technol. 222, 193–200 (2012). https://doi.org/10.1016/j.powtec.2012.02.04610.1016/j.powtec.2012.02.046 ↗
55. A. Doostmohammadi, A. Monshi, R. Salehi, M.H. Fathi, Z. Golniya, A.U. Daniels, Bioactive glass nanoparticles with negative zeta potential. Ceram. Int. 37, 2311–2316 (2011). https://doi.org/10.1016/j.ceramint.2011.03.02610.1016/j.ceramint.2011.03.026 ↗
56. Z. Tabiaa, K. El Mabrouk, M. Bricha, K. Nouneh, Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity. RSC Adv. 9, 12232–12246 (2019). https://doi.org/10.1039/C9RA01133A10.1039/C9RA01133A ↗
57. E. Beňová, D. Bergé-Lefranc, V. Zeleňák, M. Almáši, V. Huntosova, V. Hornebecq, Adsorption properties, the pH-sensitive release of 5-fluorouracil and cytotoxicity studies of mesoporous silica drug delivery matrix. Appl. Surf. Sci. 504, 144028 (2021). https://doi.org/10.1016/j.apsusc.2019.14402810.1016/j.apsusc.2019.144028 ↗
58. L. Polo, N. Gómez-Cerezo, A. García-Fernández, E. Aznar, J.-L. Vivancos, D. Arcos, M. Vallet-Regí, R. Martínez-Máñez, Mesoporous bioactive glasses equipped with stimuli-responsive molecular gates for controlled delivery of levofloxacin against bacteria. Chem. - Eur. J. 24, 18944 (2018). https://doi.org/10.1002/chem.20180330110.1002/chem.201803301 ↗