DataVXApplied Physics APaper
journal article·2024-03Open access

Fullerenol as a novel therapeutic agent for sepsis-induced cardiomyocytes damage

Tingjun Zhang, Ling Chen, Xuefeng Ding, Rendong He, Hao Wang, Junsong Guo, Shaowei Niu, Guixia Wang, Fengjun Liu, Houxiang Hu

Applied Physics A· Volume 130· Issue 3
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Abstract

Abstract Sepsis-induced myocardial damage (SIMD) is a serious complication of sepsis that affects cardiac function and prognosis. However, effective methods for the prevention and treatment of SIMD are presently lacking. This study reports the crucial function of fullerenols in protecting cardiomyocytes from septic injury. First, we applied the as-prepared fullerenols as an effective free radical scavenger and broad-spectrum anti-oxidant to protect against LPS-induced cardiomyocyte injury. Next, we verified their ability to downregulate IL-6, TNF-α, and ROS-dependent pyroptosis in AC16 induced by LPS. Finally, we observed that the protective mechanism of fullerenol against SIMD involves the regulation of the NFκB/iNOS/COX-2 pathway. This study presents a timely and essential investigation of the prevention and treatment of SIMD, providing new insights into the applications of fullerenols for therapeutic strategies.
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Research context

OpenAlex topics: Fullerene Chemistry and Applications · Anesthesia and Neurotoxicity Research · Cardiac Ischemia and Reperfusion

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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