A mucoadhesive magnetic millimeter-scale robot with two motion modes for drug delivery to the colon
Source abstract
Abstract
The small-scale robots for targeted drug delivery are gradually attracting great interest, and increasing the residence time of robots in targeted areas is conducive to increasing bioavailability. A drug-loaded magnetic millimetre-scale robot that can bond to colonic mucosa has been developed. The main body of the robot is composed of two approximately rectangular Poly (lactic acid) (PLA) sheets perpendicular to each other. The magnetic disk and the drug-loaded adhesive film are symmetrically distributed at the tail sheet. The robot has two ways to move: swimming and rolling. A high-frequency-rotating magnetic field can drive it to swim in liquid environments, or a low-frequency-rotating magnetic field can drive it to roll in an air environment. The drug-loaded adhesion patch can attach to both PLA and mucosa, ensuring the bond to the robot during movement and maintaining mucoadhesion to the intestinal mucosa during drug release. The initial contact force applied by a magnet between the robot and the intestinal surface was calculated and measured. The adhesion functionality of the robot to porcine colon was proved in the vitro simulated adhesion experiment.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Micro and Nano Robotics · Advanced Materials and Mechanics · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 201810.1016/j.ejca.2018.07.005 ↗
2. on behalf of the epidemiology and natural history task force of the international organization of inflammatory bowel disease (IOIBD), Geographical variability and environmental risk factors in inflammatory bowel disease10.1136/gutjnl-2012-303661 ↗
3. Microrobots for minimally invasive medicine10.1146/annurev-bioeng-010510-103409 ↗
4. Magnetically actuated intelligent hydrogel-based child-parent microrobots for targeted drug delivery10.1039/D0TB02384A ↗
5. Additive manufacturing of multi-material soft robot for on-demand drug delivery applications10.1016/j.jmapro.2020.03.059 ↗
6. Electromagnetic fields and human body: a new challenge for the electromagnetic field computation10.1108/03321640310474868 ↗
7. A bio-inspired attachment mechanism for long-term adhesion to the small intestine10.1007/s10544-015-9972-7 ↗
8. Multilayered mucoadhesive hydrogel films based on thiolated hyaluronic acid and polyvinylalcohol for insulin delivery10.1016/j.actbio.2012.06.027 ↗
9. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers10.1016/0378-5173(92)90353-4 ↗
10. Effect of carbomer concentration and degree of neutralization on the mucoadhesive properties of polymer films10.1163/156856201753395743 ↗
11. Innovative methods and applications in mucoadhesion research10.1002/mabi.201600534 ↗
12. Active delivery of multi-layer drug-loaded microneedle patches using magnetically driven capsule10.1016/j.medengphy.2020.09.012 ↗
13. Drug-loaded mucoadhesive patch with active delivery and controlled releasing ability10.1002/aisy.202270013 ↗
14. C. Quaglia, S. Tognarelli, E. Sinibaldi, N. Funaro, P. Dario, A. Menciassi, Wireless robotic capsule for releasing bioadhesive patches in the gastrointestinal tract, J. Med. Device. (n.d.). https://doi.org/10.1115/1.4025450.10.1115/1.4025450 ↗
15. PLA Nano- and microparticles for drug delivery: an overview of the methods of preparation10.1002/mabi.200700022 ↗
16. 3D printed oral solid dosage forms containing hydrochlorothiazide for controlled drug delivery10.1016/j.jddst.2017.06.008 ↗
17. Enhancement of PLA-PVA Surface Adhesion in Bilayer Assemblies by PLA Aminolisation10.1007/s11947-020-02475-0 ↗
18. A mussel-inspired adhesive with stronger bonding strength under underwater conditions than under dry conditions10.1039/C5CC00101C ↗
19. Evaluation of laminated muco-adhesive patches for buccal drug delivery10.1016/0378-5173(89)90347-5 ↗
20. The Use of Poly(N-vinyl pyrrolidone) in the delivery of drugs: a review10.3390/polym12051114 ↗
21. PVA/PVP blend polymer matrix for hosting carriers in facilitated transport membranes: synergistic enhancement of CO2 separation performance10.1016/j.gee.2019.10.001 ↗
22. Microfluidic synthesis of monodisperse PEGDA microbeads for sustained release of 5-fluorouracil10.1007/s10404-014-1436-5 ↗
23. An oral delivery device based on self-folding hydrogels10.1016/j.jconrel.2005.10.017 ↗
24. Rheological models for xanthan gum10.1016/0260-8774(94)00092-1 ↗
25. Poly(vinylpyrrolidone)
26. Investigations of poly(vinyl alcohol)/poly(N-vinyl-2-pyrrolidone) blends, 1. Compatibility10.1002/macp.1989.021900222 ↗
27. Removal of heavy metal ions from an aqueous solution by CS/PVA/PVP composite hydrogel synthesized using microwaved-assisted irradiation
28. Intrinsic adhesion properties of Poly(vinyl pyrrolidone) to pharmaceutical materials: humidity effect10.1002/mabi.200500146 ↗
29. Korsmeyer-Peppas, Peppas-Sahlin, and brazel-peppas: models of drug release
30. 2017
31. Solute diffusion in hydrogels.: an examination of the retardation effect10.1016/S0966-7822(97)00012-9 ↗
32. Comparative study on equivalent models calculating magnetic force between permanent magnets10.1108/JIMSE-09-2020-0009 ↗
33. Sur le calcul des forces magnétiques
34. Mucoadhesive drug delivery systems10.4103/0975-7406.76478 ↗
35. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery10.1016/S0168-3659(98)00044-3 ↗