Well ordered-microstructure bioceramics
Source abstract
Abstract
Abstract It is a great challenge to endow the bioceramics with the bone-matched mechanical performances. Here, capturing inspiration from well ordered-microstructures in the high-performance natural composites, we propose a universal biomineralization-assembly-sintering approach for the fabrication of well ordered-microstructure meta-hydroxyapatite. Owing to the well ordered-microstructure and a new metal ions-related interface toughening mechanism, this well ordered-microstructure hydroxyapatite exhibits remarkable mechanical performances, which are far beyond those of existing hydroxyapatite-based bioceramic and totally matched with the human cortical bone. Furthermore, the ordered microstructure plays a significant role in modulating the cell fates and finally stimulating bone defects regeneration in vivo. This work not only provides a strategy for the fabrication of well ordered-microstructure bioceramic but also broadens the horizons for the interface toughening mechanism of composites and microstructure design of biomaterials for bone regeneration.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Facial Trauma and Fracture Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (62)
Show source-provided references
1. In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design10.1073/pnas.2007635117 ↗
2. Combining Regeneration with Therapy10.1002/adma.202005140 ↗
3. Materials design for bone-tissue engineering10.1038/s41578-020-0204-2 ↗
4. Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity10.1021/acs.chemmater.8b01272 ↗
5. Bioinspired structural materials10.1038/nmat4089 ↗
6. Abiotic tooth enamel10.1038/nature21410 ↗
7. Synthetic nacre by predesigned matrix-directed mineralization10.1126/science.aaf8991 ↗
8. Structure and Mechanical Adaptability of a Modern Elasmoid Fish Scale from the Common Carp10.1016/j.matt.2020.05.011 ↗
9. A natural impact-resistant bicontinuous composite nanoparticle coating10.1038/s41563-020-0768-7 ↗
10. Freezing as a Path to Build Complex Composites10.1126/science.1120937 ↗
11. Bioinspired Hydroxyapatite/Poly(methyl methacrylate) Composite with a Nacre-Mimetic Architecture by a Bidirectional Freezing Method10.1002/adma.201504313 ↗
12. Super-tough MXene-functionalized graphene sheets10.1038/s41467-020-15991-6 ↗
13. Bio-inspired nacre-like composite films based on graphene with superior mechanical, electrical, and biocompatible properties10.1002/adma.201200452 ↗
14. Graphene oxide as a chemically tunable platform for optical applications10.1038/nchem.907 ↗
15. Super-tough artificial nacre based on graphene oxide via synergistic interface interactions of π-π stacking and hydrogen bonding10.1016/j.carbon.2016.10.067 ↗
16. Graphene Oxide Papers Modified by Divalent Ions-Enhancing Mechanical Properties via Chemical Cross-Linking10.1021/nn700349a ↗
17. Assembly Preparation of Multilayered Biomaterials with High Mechanical Strength and Bone-Forming Bioactivity10.1021/acs.chemmater.8b01272 ↗
18. Effect of sintering pressure on the texture of hot-press sintered hexagonal boron nitride composite ceramics10.1016/j.scriptamat.2012.09.012 ↗
19. Intermolecular channels direct crystal orientation in mineralized collagen10.1038/s41467-020-18846-2 ↗
20. The nanocomposite nature of bone drives its strength and damage resistance10.1038/nmat4719 ↗
21. Preparation and mechanical properties of controllable orthogonal arrangement of carbon fiber reinforced hydroxyapatite composites10.1016/j.ceramint.2018.02.020 ↗
22. Improved properties of hydroxyapatite–carbon nanotube biocomposite: Mechanical, in vitro bioactivity and biological studies10.1016/j.ceramint.2013.10.158 ↗
23. An efficient method to prepare magnetic hydroxyapatite-functionalized multi-walled carbon nanotubes nanocomposite for bone defects10.1016/j.msec.2018.02.002 ↗
24. Spark Plasma Sintered Hydroxyapatite/Graphite Nanosheet and Hydroxyapatite/Multiwalled Carbon Nanotube Composites: Mechanical and in Vitro Cellular Properties10.1002/adem.201000300 ↗
25. A tough graphene nanosheet/hydroxyapatite composite with improved in vitro biocompatibility10.1016/j.carbon.2013.04.074 ↗
26. Mechanical properties and biomedical applications of a nanotube hydroxyapatite-reduced graphene oxide composite10.1016/j.carbon.2013.11.054 ↗
27. Effects of the addition of boron nitride nanoplate on the fracture toughness, flexural strength, and Weibull Distribution of hydroxyapatite composites prepared by spark plasma sintering10.1016/j.jmbbm.2019.01.021 ↗
28. Effect of TiO2 doping on densification and mechanical properties of hydroxyapatite by microwave sintering10.1016/j.ceramint.2019.04.007 ↗
29. Twinning induced enhancement of fracture toughness in ultrafine grained Hydroxyapatite–Calcium Titanate composites10.1016/j.jeurceramsoc.2015.10.044 ↗
30. Fabrication of hydroxyapatite/diopside/alumina composites by hot-press sintering process10.1016/j.ceramint.2008.10.027 ↗
31. Effect of the addition ZrO2–Al2O3 on nanocrystalline hydroxyapatite bending strength and fracture toughness10.1016/j.ceramint.2008.08.017 ↗
32. Morphological Correlations to Mechanical Performance of Hydroxyapatite-Filled HDPE/UHMWPE Composites
33. Sintered Hydroxyapatite/Polyetheretherketone Nanocomposites: Mechanical Behavior and Biocompatibility10.1002/adem.201080145 ↗
34. Processing and Properties of HAp Based Biomaterials for Use as Hard Tissue Replacement Implants10.1557/JMR.1998.0015 ↗
35. A novel injectable, cohesive and toughened Si-HPMC (silanized-hydroxypropyl methylcellulose) composite calcium phosphate cement for bone substitution10.1016/j.actbio.2014.03.009 ↗
36. Nanocrystalline hydroxyapatite with simultaneous enhancements in hardness and toughness10.1016/j.biomaterials.2009.08.048 ↗
37. Bioinspired Biomaterials with a Brick-and-Mortar Microstructure Combining Mechanical and Biological Performance10.1002/adhm.201901211 ↗
38. A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair10.1016/j.actbio.2010.07.012 ↗
39. Densification route and mechanical properties of Si3N4Γאףbioglass biocomposites10.1016/S0142-9612(01)00194-6 ↗
40. Mechanical properties of biomedical titanium alloys10.1016/S0921-5093(97)00806-X ↗
41. A Novel Akermanite Bioceramic: Preparation and Characteristics10.1177/0885328206057953 ↗
42. BIOCERAMICS - FROM CONCEPT TO CLINIC10.1111/j.1151-2916.1991.tb07132.x ↗
43. On the toughness enhancement in hydroxyapatite-based composites10.1016/j.actamat.2013.05.013 ↗
44. Munch · Tough, Bio-Inspired Hybrid Materials, Science · 2008 · 322 · 1516
45. Layered nanocomposites by shear-flow-induced alignment of nanosheets10.1038/s41586-020-2161-8 ↗
46. Mechanical and electrical properties of aligned carbon nanotube/carbon matrix composites10.1016/j.carbon.2014.04.008 ↗
47. Carbon Nanotube Reinforced Strong Carbon Matrix Composites10.1021/acsnano.0c03268 ↗
48. Catalytic effect of iron oxide on carbon/carbon composites during graphitization10.1016/S0008-6223(97)00134-6 ↗
49. Construction of a Nanoporous Highly Crystalline Hexagonal Boron Nitride from an Amorphous Precursor for Catalytic Dehydrogenation10.1002/anie.201904996 ↗
50. Ion-Catalyzed Synthesis of Microporous Hard Carbon Embedded with Expanded Nanographite for Enhanced Lithium/Sodium Storage10.1021/jacs.6b06673 ↗
51. Three-dimensional porous graphene-like sheets synthesized from biocarbon via low-temperature graphitization for a supercapacitor10.1039/C7GC03426A ↗
52. Catalytic graphitization of carbons by various metals10.1016/0008-6223(79)90020-4 ↗
53. Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment10.1016/S1534-5807(04)00075-9 ↗
54. Geometric cues for directing the differentiation of mesenchymal stem cells10.1073/pnas.0903269107 ↗
55. A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration10.1016/j.biomaterials.2018.02.010 ↗
56. Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A
57. Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings10.1016/S0142-9612(99)00255-0 ↗
58. Periosteum-mimetic structures made from freestanding microgrooved nanosheets10.1002/adma.201305804 ↗
59. Fabricating hierarchical micro and nano structures on implantable Co-Cr-Mo alloy for tissue engineering by one-step laser ablation10.1016/j.colsurfb.2017.11.040 ↗
60. Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment10.1021/acsnano.8b04758 ↗
61. The current graphene safety landscape–a literature mining exercise10.1039/C5NR00236B ↗
62. The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology10.1021/acsnano.6b03358 ↗