Biomaterial-based osteoimmunomodulatory strategies via the TLR4-NF-κB signaling pathway: A review
Source abstract
Abstract
Abstract Osteoimmunomodulation (OIM) has revealed an important role for immune cells in regulating osseointegration. Biomaterials for OIM have contributed to the evaluation of orthopedic biomaterials and have been used to demonstrate a strong correlation between OIM and bone healing. Evaluation of OIM biomaterials is based on the behavior of immune cells, and has evolved from classic macrophage phenotype identification to evaluation of key immune-related signaling pathways, improving understanding of the mechanism of action of OIM biomaterials. TLR4-NF-κB, a classic implant-related innate immune recognition and immunomodulation signaling pathway, has attracted widespread attention. Biomaterials have increasingly been designed and evaluated in the context of this pathway and a strong correlation with bone healing suggests it contributes to the mechanism of action of OIM biomaterials. This review summarizes empirical and precise strategies for designing OIM biomaterials that act via the TLR4-NF-κB pathway, and attempts to stimulate new ideas for the design of OIM biomaterials based on the interaction of materials with signaling mechanisms.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopedic Infections and Treatments · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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