journal article·2022-03Open access

Development of an alveolar chip model to mimic respiratory conditions due to fine particulate matter exposure

Ko-Chih Lin, Jia-Wei Yang, Pei-Yi Ho, Chun-Zai Yen, Hao-Wei Huang, Hsuan-Yu Lin, Johnson Chung, Guan-Yu Chen

Abstract

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Research context

OpenAlex topics: Inhalation and Respiratory Drug Delivery · Air Quality Monitoring and Forecasting · Air Quality and Health Impacts

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References (54)

Show source-provided references
1. Effect of long-term exposure to fine particulate matter on lung function decline and risk of chronic obstructive pulmonary disease in Taiwan: a longitudinal, cohort study10.1016/S2542-5196(18)30028-7 ↗
2. Particulate-matter related respiratory diseases10.4046/trd.2019.0025 ↗
3. Loss of life expectancy from air pollution compared to other risk factors: a worldwide perspective10.1093/cvr/cvaa025 ↗
4. Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action10.1016/S0140-6736(16)31597-5 ↗
5. Toxicity research of PM2.5 compositions in vitro10.3390/ijerph14030232 ↗
6. In vitro and in vivo experimental studies of PM2.5 on disease progression10.3390/ijerph15071380 ↗
7. Novel evidence for a greater burden of ambient air pollution on cardiovascular disease10.3324/haematol.2019.225086 ↗
8. Air pollution and cardiovascular disease: car sick
9. New approach methods to evaluate health risks of air pollutants: critical design considerations for in vitro exposure testing10.3390/ijerph17062124 ↗
10. Particulate air pollution: major research methods and applications in animal models10.4103/ed.ed_16_18 ↗
11. In vitro Alternatives to acute inhalation toxicity studies in animal models-a perspective10.3389/fbioe.2020.00549 ↗
12. Is it time for reviewer 3 to request human organ chip experiments instead of animal validation studies?10.1002/advs.202002030 ↗
13. Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach?10.1016/j.jacbts.2019.10.008 ↗
14. Organs-on-chips: into the next decade10.1038/s41573-020-0079-3 ↗
15. Robotic fluidic coupling and interrogation of multiple vascularized organ chips10.1038/s41551-019-0497-x ↗
16. Lung-on-a-chip: the future of respiratory disease models and pharmacological studies10.1080/07388551.2019.1710458 ↗
17. Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro10.1038/nmeth.3697 ↗
18. A microengineered airway lung chip models key features of viral-induced exacerbation of asthma10.1165/rcmb.2020-0010MA ↗
19. Reconstituting organ-level lung functions on a chip10.1126/science.1188302 ↗
20. Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip10.1016/j.cels.2016.10.003 ↗
21. Primary human lung alveolus-on-a-chip model of intravascular thrombosis for assessment of therapeutics10.1002/cpt.742 ↗
22. Critical determinants of uptake and translocation of nanoparticles by the human pulmonary alveolar epithelium10.1021/nn505399e ↗
23. Use of porous membranes in tissue barrier and co-culture models10.1039/C7LC01248A ↗
24. Stable chemical bonding of porous membranes and poly (dimethylsiloxane) devices for long-term cell culture10.1063/1.4883075 ↗
25. Organ-on-a-chip: recent breakthroughs and future prospects10.1186/s12938-020-0752-0 ↗
26. Organ-on-a-chip: opportunities for assessing the toxicity of particulate matter10.3389/fbioe.2020.00519 ↗
27. An estimation of mechanical stress on alveolar walls during repetitive alveolar reopening and closure10.1152/japplphysiol.00112.2015 ↗
28. Primary human lung alveolus-on-a-chip model of intravascular thrombosis for assessment of therapeutics10.1002/cpt.742 ↗
29. Emerging encapsulation technologies for long-term reliability of microfabricated implantable devices10.3390/mi10080508 ↗
30. Air-liquid interface: relevant in vitro models for investigating air pollutant-induced pulmonary toxicity10.1093/toxsci/kfy053 ↗
31. 3D alveolar in vitro model based on epithelialized biomimetically curved culture membranes10.1016/j.biomaterials.2020.120436 ↗
32. Dynamics of coarse and fine particle exposure in transport microenvironments10.1038/s41612-018-0023-y ↗
33. Direct and indirect effects of particulate matter on the cardiovascular system10.1016/j.toxlet.2011.11.008 ↗
34. The impact of PM2.5 on the human respiratory system
35. Diesel exhaust particles exacerbate allergic rhinitis in mice by disrupting the nasal epithelial barrier10.1111/cea.12597 ↗
36. Air pollutant-mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway10.1016/j.jaci.2016.06.027 ↗
37. In vitro evaluation of organic extractable matter from ambient PM2.5 using human bronchial epithelial BEAS-2B cells: cytotoxicity, oxidative stress, pro-inflammatory response, genotoxicity, and cell cycle deregulation10.1016/j.envres.2019.01.052 ↗
38. Air-liquid interface exposure of lung epithelial cells to low doses of nanoparticles to assess pulmonary adverse effects10.3390/nano11010065 ↗
39. Source apportionment of fine-particle, water-soluble organic nitrogen and its association with the inflammatory potential of lung epithelial cells10.1021/acs.est.9b02523 ↗
40. Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties10.1186/s12989-020-00369-9 ↗
41. Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing10.1039/C9LC00253G ↗
42. Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips10.1038/s41551-019-0498-9 ↗
43. Organs-on-chips: into the next decade10.1038/s41573-020-0079-3 ↗
44. High-throughput tumor-on-a-chip platform to study tumor-stroma interactions and drug pharmacokinetics10.1002/adhm.202000880 ↗
45. Assessment of hospitalization and mortality from exposure to PM10 using AirQ modeling in Ilam, Iran10.1007/s11356-017-9794-7 ↗
46. Formation of urban fine particulate matter10.1021/acs.chemrev.5b00067 ↗
47. Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence10.1007/s00038-019-01202-7 ↗
48. Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung10.1089/jamp.2015.1270 ↗
49. Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives10.1186/s12989-018-0282-0 ↗
50. An in vitro coculture system for the detection of sensitization following aerosol exposure
51. Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein tricellulin10.1186/s12989-020-00383-x ↗
52. Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)10.1186/s12989-018-0257-1 ↗
53. Analysis of carcinogenic polycyclic aromatic hydrocarbons in complex environmental mixtures by LC-APPI-MS/MS10.1016/j.aca.2011.07.003 ↗
54. Single-use porous thin film extraction with gas chromatography atmospheric pressure chemical ionization tandem mass spectrometry for high-throughput analysis of 16 PAHs10.1016/j.talanta.2019.120320 ↗