A doxorubicin and siRNA coloaded nanolamellar hydroxyapatite/PLGA electrospun scaffold as a safe antitumor drug delivery system
Source abstract
Abstract
To circumvent the severe cytotoxicity and drug resistance of chemotherapeutics in cancer chemotherapy, we rationally designed an electrospun nanofibrous delivery system for the codelivery of the doxorubicin (DOX) and small interfering ribonucleic acid (siRNA) to improve antitumor activity and mitigate DOX drug resistance. DOX was intercalated into nanolamellar hydroxyapatite (LHAp), which was incorporated into electrospun poly(lactic-co-glycolic acid) (PLGA) nanofibers, and finally, the DOX-intercalated LHAp/PLGA scaffold was coated with polydopamine (PDA) followed by immobilization with siRNA/polyethyleneimine (PEI) complexes. Benefiting from its intrinsic degradability, the scaffold demonstrated pH-responsive release behavior, leading to the simultaneous delivery of DOX and siRNA. Consequently, the codelivery scaffold demonstrated enhanced therapeutic efficiency in vitro and in vivo compared with the scaffold loaded with single drug due to the combined effects of DOX and siRNA and did not show toxicity or side effects in mice. Therefore, it is a safe and effective strategy for preventing postsurgical tumor recurrence.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Graphene and Nanomaterials Applications · Tissue Engineering and Regenerative Medicine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (44)
Show source-provided references
1. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment10.1038/s41565-018-0319-4 ↗
2. Biopolymers for antitumor implantable drug delivery systems: recent advances and future outlook10.1002/adma.201706665 ↗
3. Using scaffolds as drug delivery systems to treat bone tumor
4. Electrospinning: applications in drug delivery and tissue engineering10.1016/j.biomaterials.2008.01.011 ↗
5. Electrospun polymer micro/nanofibers as pharmaceutical repositories for healthcare10.1016/j.jconrel.2019.03.020 ↗
6. Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses10.1039/C9CS00271E ↗
7. Advances in drug delivery for post-surgical cancer treatment10.1016/j.biomaterials.2019.04.027 ↗
8. Antitumor efficacy of doxorubicin-loaded electrospun nano-hydroxyapatite–poly (lactic-co-glycolic acid) composite nanofibers10.1039/C2PY20779F ↗
9. Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation10.1016/j.ejpb.2012.08.012 ↗
10. Polymer implants for intratumoral drug delivery and cancer therapy10.1002/jps.21038 ↗
11. Enhanced composite electrospun nanofiber scaffolds for use in drug delivery10.1517/17425247.5.10.1093 ↗
12. Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment10.1016/j.mattod.2014.05.002 ↗
13. Photostable and biocompatible fluorescent silicon nanoparticles for imaging-guided co-delivery of siRNA and doxorubicin to drug-resistant cancer cells10.1007/s40820-019-0257-1 ↗
14. pH-sensitive CAP/SiO2 composite for efficient co-delivery of doxorubicin and siRNA to overcome multiple drug resistance10.1039/C9RA07894K ↗
15. Conjugation of doxorubicin to siRNA through disulfide-based self-immolative linkers10.3390/molecules25112714 ↗
16. Co-delivery of siRNA and doxorubicin to cancer cells from additively manufactured implants10.1039/C5RA23748C ↗
17. RRS measurements and DFT calculation for doxorubicin10.1002/jemt.20849 ↗
18. Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment10.2147/IJN.S150610 ↗
19. Phenylboronic acid-modified hollow silica nanoparticles for dual-responsive delivery of doxorubicin for targeted tumor therapy
20. Biodegradable hybrid mesoporous silica nanoparticles for gene/chemo-synergetic therapy of breast cancer10.1177/0885328219835490 ↗
21. Host-guest supramolecular hydrogel based on nanoparticles: co-delivery of DOX and siBcl-2 for synergistic cancer therapy10.1080/09205063.2019.1612602 ↗
22. Co-delivery of doxorubicin and anti-BCL-2 siRNA by pH-responsive polymeric vector to overcome drug resistance in in vitro and in vivo HepG2 hepatoma model10.1021/acs.biomac.8b00272 ↗
23. Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy10.1016/j.biomaterials.2020.119760 ↗
24. EGF-modified mPEG-PLGA-PLL nanoparticle for delivering doxorubicin combined with Bcl-2 siRNA as a potential treatment strategy for lung cancer10.3109/10717544.2015.1126769 ↗
25. Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance
26. Enwrapping polydopamine on doxorubicin-loaded lamellar hydroxyapatite/poly (lactic-co-glycolic acid) composite fibers for inhibiting10.1021/acsabm.1c00297 ↗
27. Incorporating nanoplate-like hydroxyapatite into polylactide for biomimetic nanocomposites via direct melt intercalation10.1016/j.compscitech.2019.107903 ↗
28. Encapsulating doxorubicin-intercalated lamellar nanohydroxyapatite into PLGA nanofibers for sustained drug release10.1016/j.cap.2019.08.003 ↗
29. Engineering photoluminescent and magnetic lamellar hydroxyapatite by facile one-step Se/Gd dual-doping10.1039/C8TB00658J ↗
30. Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells10.1016/j.biomaterials.2013.01.093 ↗
31. bFGF-grafted electrospun fibrous scaffolds via poly(dopamine) for skin wound healing10.1039/C3TB21814G ↗
32. Preparation and in vitro degradation of PLGA/HA composite fiber scaffolds by electrospinning10.4028/www.scientific.net/AMR.591-593.982 ↗
33. 3D superhydrophobic electrospun meshes as reinforcement materials for sustained local drug delivery against colorectal cancer cells10.1016/j.jconrel.2012.05.047 ↗
34. Doxorubicin loaded carboxymethyl cellulose/graphene quantum dot nanocomposite hydrogel films as a potential anticancer drug delivery system10.1016/j.msec.2018.02.010 ↗
35. Mussel-inspired modification of nanofibers for REST siRNA delivery: understanding the effects of gene-silencing and substrate topography on human mesenchymal stem cell neuronal commitment10.1002/mabi.201500101 ↗
36. Co-delivery of Se nanoparticles and pooled siRNAs for overcoming drug resistance mediated by P-glycoprotein and class III beta-tubulin in drug-resistant breast cancers10.1016/j.actbio.2015.11.041 ↗
37. Probing the effect of miRNA on siRNA−PEI polyplexes10.1021/acs.jpcb.5b00415 ↗
38. Gold nanorods-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells10.1039/C8NR03802C ↗
39. Cancer drug resistance: an evolving paradigm10.1038/nrc3599 ↗
40. Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies10.1016/j.addr.2015.10.023 ↗
41. Co-delivery of IL17RB siRNA and doxorubicin by chitosan-based nanoparticles for enhanced anticancer efficacy in breast cancer cells10.1016/j.biopha.2016.06.037 ↗
42. Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin10.1021/nn2013707 ↗
43. Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer10.1002/med.20244 ↗
44. Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy10.1016/j.scib.2020.04.012 ↗