journal article·2022-08Open access

Eumelanin-based multisensory platform: A case of study for photolithographic patterning

João V. Paulin, Luiz G.S. Albano, Davi H.S. Camargo, Mariane P. Pereira, Bruna A. Bregadiolli, Carlos F.O. Graeff, Carlos C.B. Bufon

Abstract

Eumelanin, the most abundant brown-black pigment found in humans, is an ideal candidate for bioelectronics and eco-design technologies due to its biocompatibility, biodegradability, and hydration-dependent conductivity. Here, we validate the use of standard photolithography for integrating synthetic eumelanin into robust solid-state device platforms without unconventional methodologies. By combining AFM, Raman, and XPS with DC and AC electrical measurements, we have shown that eumelanin's film topography, chemical composition, and charge transport are not affected by the pattern process. Based on these findings, we explore interdigitated electrode structures for pH, humidity, and contact sensing system aiming at miniaturized wearable technologies for human healthcare monitoring.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: melanin and skin pigmentation · Biochemical Analysis and Sensing Techniques · Olfactory and Sensory Function Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (78)

Show source-provided references
1. The physical and chemical properties of eumelanin10.1111/j.1600-0749.2006.00345.x ↗
2. Biodegradation of bio-sourced and synthetic organic electronic materials towards green organic electronics10.1038/s41467-021-23227-4 ↗
3. The nature of the charge carriers in solvated biomacromolecules10.1007/BF01517187 ↗
4. Electrical conductivity of synthetic DOPA-melanin polymer for different hydration states and temperatures10.1163/156856295X00490 ↗
5. N. Amdursky, E.D. Głowacki, P. Meredith, Macroscale biomolecular electronics and ionics, Adv. Mater. 31 (2019) 1802221. 10.1002/adma.201802221.10.1002/adma.201802221 ↗
6. Role of semiconductivity and ion transport in the electrical conduction of melanin10.1073/pnas.1119948109 ↗
7. Protonic and electronic transport in hydrated thin films of the pigment eumelanin10.1021/cm502939r ↗
8. Decoupling ionic and electronic currents in melanin10.1002/adfm.201805514 ↗
9. Melanin thin-films: a perspective on optical and electrical properties10.1039/D1TC01440D ↗
10. Melanin, the what, the why and the how: an introductory review for materials scientists interested in flexible and versatile polymers10.3390/polym13101670 ↗
11. From nature to organic (bio)electronics: a review on a melanin-inspired material10.1039/D1TC03029A ↗
12. Y.J. Kim, W. Wu, S. Chun, J.F. Whitacre, C.J. Bettinger, Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices, Proc. Natl. Acad. Sci. 110 (2013) 20912–20917. 10.1073/pnas.1314345110.10.1073/pnas.1314345110 ↗
13. Catechol-mediated reversible binding of multivalent cations in eumelanin half-cells10.1002/adma.201402295 ↗
14. An all-solid-state biocompatible ion-to-electron transducer for bioelectronics10.1039/C7MH00831G ↗
15. Melanin as an active layer in biosensors
16. Printable and flexible graphene pH sensors utilising Thin film melanin for physiological applications10.1088/2053-1583/ab72d5 ↗
17. Melanin-based flexible supercapacitors10.1039/C6TC03739A ↗
18. Solid-state electrochemical energy storage based on soluble melanin10.3390/electrochem2020019 ↗
19. Ultraviolet-protective thin film based on PVA–melanin/rod-coated silver nanowires and its application as a transparent capacitor10.1002/app.47805 ↗
20. The reduction of Ag+ in metallic silver on pseudomelanin films allows for antibacterial activity but does not imply unpaired electrons10.1016/j.jcis.2011.08.038 ↗
21. Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a natural-derived polymer10.1016/j.msec.2017.03.169 ↗
22. Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies10.1557/mrc.2017.33 ↗
23. Eumelanin-Fe3O4 hybrid nanoparticles for enhanced MR/PA imaging-assisted local photothermolysis10.1039/C8BM00003D ↗
24. Engineering proton conductivity in melanin using metal doping10.1039/D0TB01390K ↗
25. Micropatterned silk-fibroin/eumelanin composite films for bioelectronic applications10.1021/acsbiomaterials.1c00216 ↗
26. Purity of organic semiconductors as a key factor for the performance of organic electronic devices10.1039/D0QM00690D ↗
27. Sulfonated melanin derivatives: theoretical evaluation of local reactivities and chemical structures10.1007/s00894-021-04982-z ↗
28. Biocompatibility investigations of synthetic melanin and melanin analogue for application in bioelectronics10.1002/pi.5192 ↗
29. Structural and optical properties of soluble melanin analogues with enhanced photoluminescence quantum efficiency10.1002/pi.5543 ↗
30. Low-voltage, flexible, and self-encapsulated ultracompact organic thin-film transistors based on nanomembranes10.1021/acs.nanolett.8b01958 ↗
31. Ambipolar resistive switching in an ultrathin surface-supported metal-organic framework vertical heterojunction10.1021/acs.nanolett.9b04355 ↗
32. Edge-driven nanomembrane-based vertical organic transistors showing a multi-sensing capability10.1038/s41467-020-14661-x ↗
33. Ultrahigh-gain organic electrochemical transistor chemosensors based on self-curled nanomembranes
34. Temperature-enhanced synthesis of DMSO-Melanin10.1016/j.molstruc.2013.10.041 ↗
35. Novel insights on the physicochemical properties of eumelanins and their DMSO derivatives10.1002/pi.5167 ↗
36. Melanin system composition analyzed by XPS depth profiling
37. Synthesis and characterization of melanin in DMSO10.1016/j.molstruc.2013.04.061 ↗
38. Shedding light on the free radical nature of sulfonated melanins10.1021/acs.jpcb.0c08097 ↗
39. A strategy towards melanin-based functional material: rGO and sulfonated melanin composites10.1039/D1TC02749B ↗
40. Humidity-sensing properties of chemically reduced graphene oxide/polymer nanocomposite film sensor based on layer-by-layer nano self-assembly10.1016/j.snb.2014.02.078 ↗
41. Paper-based electrical respiration sensor10.1002/anie.201511805 ↗
42. Synthesis of water-soluble dopamine–melanin for ultrasensitive and ultrafast humidity sensor10.1016/j.snb.2015.10.015 ↗
43. Paper skin multisensory platform for simultaneous environmental monitoring10.1002/admt.201600004 ↗
44. Rapid-response, reversible and flexible humidity sensing platform using a hydrophobic and porous substrate10.1039/C8TB02963F ↗
45. Bio-compatible organic humidity sensor based on natural inner egg shell membrane with multilayer crosslinked fiber structure10.1038/s41598-019-42337-0 ↗
46. High-sensitivity wearable and flexible humidity sensor based on graphene oxide/non-woven fabric for respiration monitoring10.1021/acs.langmuir.0c01315 ↗
47. Novel application of attapulgite on high performance and low-cost humidity sensors10.1016/j.snb.2019.127534 ↗
48. Halloysite nanotubes: natural, environmental-friendly and low-cost nanomaterials for high-performance humidity sensor10.1016/j.snb.2020.128204 ↗
49. Facile and low-cost fabrication of a humidity sensor using naturally available sepiolite nanofibers10.1088/1361-6528/ab932c ↗
50. A flexible humidity sensor based on natural biocompatible silk fibroin films10.1002/admt.202001053 ↗
51. Ingestible, biofriendly, and flexible flour-based humidity sensors with a wide sensing range10.1021/acsaelm.1c00372 ↗
52. Food-based highly sensitive capacitive humidity sensors by inkjet printing for human body monitoring10.1021/acsaelm.1c00570 ↗
53. Investigation into the Suitability of screen printed graphene-melanin ph sensors for use in bacterial culturing applications10.1016/j.jelechem.2021.115868 ↗
54. Gaseous adsorption in melanins: hydrophilic biomacromolecules with high electrical conductivities10.1021/la901290f ↗
55. An ultrasensitive and fast moisture sensor based on self-assembled dopamine-melanin thin films10.1002/admi.201500203 ↗
56. Flexible noncontact sensing for human–machine interaction
57. Textile-based wireless pressure sensor array for human-interactive sensing
58. Self-powered pressure- and vibration-sensitive tactile sensors for learning technique-based neural finger skin10.1021/acs.nanolett.9b00922 ↗
59. Electric-field-induced gradient ionogels for highly sensitive, broad-range-response, and freeze/heat-resistant ionic fingers10.1002/adma.202008486 ↗
60. Nomex paper-based double-sided laser-induced graphene for multifunctional human-machine interface10.1016/j.carbon.2022.03.026 ↗
61. Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing10.1038/s41467-017-02685-9 ↗
62. Polymer optical fiber for monitoring human physiological and body function: a comprehensive review on mechanisms, materials, and applications10.1016/j.optlastec.2021.107626 ↗
63. Recent advances in humidity sensors for human body related humidity detection10.1039/D1TC04180K ↗
64. Recent advances in multiresponsive flexible sensors towards e-skin: a delicate design for versatile sensing
65. Multifunctional hybrid skin patch for wearable smart healthcare applications10.1016/j.bios.2021.113685 ↗
66. Biodegradability and anticoagulant properties of chitosan and sulfonated chitosan films coated on TiNi alloys10.1016/j.surfcoat.2012.05.121 ↗
67. Effect of modified lignin sulfonate on controlled-release urea in soil10.1007/s10924-016-0848-6 ↗
68. Biodegradable PEDOT:PSS/clay composites for multifunctional green-electronic materials10.1002/adsu.202100056 ↗
69. Advanced materials for health monitoring with skin-based wearable devices10.1002/adhm.201700024 ↗
70. Materials and wearable devices for autonomous monitoring of physiological markers
71. Influence of pH on wound-healing: a new perspective for wound-therapy?10.1007/s00403-006-0713-x ↗
72. The role of biomedical sensors in wound healing10.1016/j.wndm.2015.03.007 ↗
73. Challenges in the treatment of chronic wounds10.1089/wound.2015.0635 ↗
74. Advanced wound dressing for real-time pH monitoring10.1021/acssensors.1c00552 ↗
75. Inkjet-printed paper-based sensor array for highly accurate pH sensing10.1016/j.aca.2021.338275 ↗
76. N.B. Guerra, G. Sant'Ana Pegorin, M.H. Boratto, N.R. de Barros, C.F. de Oliveira Graeff, R.D. Herculano, Biomedical applications of natural rubber latex from the rubber tree Hevea brasiliensis, Mater. Sci. Eng. C. Mater. Biol. Appl. 126 (2021) 112126. 10.1016/j.msec.2021.112126.10.1016/j.msec.2021.112126 ↗
77. Eumelanin-releasing spongy-like hydrogels for skin re-epithelialization purposes10.1088/1748-605X/aa5f79 ↗
78. The role and mechanism of polydopamine and cuttlefish ink melanin carrying copper ion nanoparticles in antibacterial properties and promoting wound healing10.1039/D1BM00622C ↗