An elastic auto-bone patch for one-step repair large skull defects accompanied by Craniocerebral injury
Source abstract
Abstract
Abstract Large area skull defects accompanied by craniocerebral injury are life-threating diseases that are difficult to treat due to the large area of damage and intracranial hypertension. An autologous bone is an ideal source for the regeneration of bone, including skull defects. However, two-step treatment, including craniectomy and cranioplasty, is the main strategy in clinical practice to stabilize intracranial pressure, but still remains a huge obstacle in both the preservation of auto-bone fragments and protection of exposed brain tissue. In this study, an elastic auto-bone patch was developed to provide a new and one-step method for repairing large skull defects which are currently repaired with two stages of surgery. The elastic auto-bone patch is formed by bonding auto-bone fragments together using hydrogels, which is then re-implanted to bone defects to repair large skull defects. The auto-bone patch could adapt to changes in intracranial pressure to protect brain tissue for damage, integrate well with surrounding bone tissues, and promote bone regeneration. After 8 weeks implantation, the large-size skull defect is filled with new formed bone tissues in the group of treating with auto-bone patch. This study introduced a new procedure on the application of elastic auto-bone patch to repair large area skull defects.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Traumatic Brain Injury and Neurovascular Disturbances · Bone Tissue Engineering Materials · Facial Trauma and Fracture Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (40)
Show source-provided references
1. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research10.1016/S1474-4422(17)30371-X ↗
2. Traumatic brain injury in China10.1016/S1474-4422(18)30469-1 ↗
3. Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep10.1126/scitranslmed.aam8828 ↗
4. Traumatic brain injury10.1007/s00115-015-0051-3 ↗
5. Traumatic Brain Injury: current Treatment Strategies and Future Endeavors10.1177/0963689717714102 ↗
6. Intracerebral haemorrhage: current approaches to acute management
7. Early management of severe traumatic brain injury10.1016/S0140-6736(12)60864-2 ↗
8. Titanium in reconstructive surgery of the skull and face10.1016/0007-1226(90)90115-G ↗
9. Long-term results following reconstruction of craniofacial defects with titanium micro-mesh systems10.1054/jcms.2001.0197 ↗
10. Outcomes of titanium mesh cranioplasty in pediatric patients10.1097/SCS.0000000000004045 ↗
11. Cranioplasty: review of materials and techniques10.4103/0976-3147.83584 ↗
12. Repairing Holes in the Head: a History of Cranioplasty
13. Fracture healing in osteoporotic bone10.1016/S0020-1383(16)47004-X ↗
14. Injectable hydrogels for cartilage and bone tissue engineering
15. Design and biological functionality of a novel hybrid Ti-6Al-4V/hydrogel system for reconstruction of bone defects10.1002/term.2614 ↗
16. Tuning physical properties and BMP-2 release rates of injectable hydrogel systems for an optimal bone regeneration effect10.1016/j.biomaterials.2017.01.016 ↗
17. A 3D Printable and Bioactive Hydrogel Scaffold to Treat traumatic brain injury10.1002/adfm.201904450 ↗
18. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds10.1038/s41467-019-10004-7 ↗
19. Tissue-integratable and biocompatible photogelation by the imine crosslinking reaction10.1002/adma.201505336 ↗
20. Structural and rheological properties of methacrylamide modified gelatin hydrogels10.1021/bm990017d ↗
21. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels10.1016/j.biomaterials.2015.08.045 ↗
22. Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels10.1016/j.actbio.2011.01.016 ↗
23. Cell-laden microengineered gelatin methacrylate hydrogels10.1016/j.biomaterials.2010.03.064 ↗
24. Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility10.1016/j.biomaterials.2009.08.055 ↗
25. Adipose tissue-derived stromal cells (ADSC) express oligodendrocyte and myelin markers, but they do not function as oligodendrocytes10.1007/s00418-017-1588-y ↗
26. Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing m2 macrophages and beiging in white adipose tissue10.2337/db17-0356 ↗
27. Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration10.1016/j.biomaterials.2013.10.056 ↗
28. Biological adhesive based on carboxymethyl chitin derivatives and chitin nanofibers10.1016/j.biomaterials.2014.11.043 ↗
29. An in situ phototriggered-imine-crosslink composite hydrogel for bone defect repair10.1039/C5TB02377G ↗
30. Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair10.1016/j.addr.2015.03.013 ↗
31. A systematic review on the critical size defect model10.1111/clr.12194 ↗
32. In vivo therapeutic effect of wollastonite and hydroxyapatite on bone defect10.1088/1748-605X/ab4238 ↗
33. Risk factors for post-traumatic massive cerebral infarction secondary to space-occupying epidural hematoma10.1089/neu.2013.3142 ↗
34. The use of injectable, thermosensitive poly(organophosphazene)-RGD conjugates for the enhancement of mesenchymal stem cell osteogenic differentiation10.1016/j.biomaterials.2009.08.011 ↗
35. Biomaterial delivery of morphogens to mimic the natural healing cascade in bone10.1016/j.addr.2012.05.006 ↗
36. TGF-β and BMP Signaling in osteoblast differentiation and bone formation10.7150/ijbs.2929 ↗
37. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration10.1016/j.biomaterials.2016.05.043 ↗
38. Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects10.1021/acscentsci.8b00764 ↗
39. In vivo sequestration of innate small molecules to promote bone healing
40. Small molecule–driven direct conversion of human pluripotent stem cells into functional osteoblasts