journal article·2022-06

Induction heating for the removal of liquid metal-based implant mimics: A proof-of-concept

Roozbeh Abbasi, Jianbo Tang, Mahroo Baharfar, Chengchen Zhang, Francois-Marie Allioux, Jin Zhang, Mohammad Tajik, Jiong Yang, Joanna Biazik, Franco Centurion, Jialuo Han, Sajjad S. Mofarah, Dorna Esrafilzadeh, Pramod Koshy, Charles C. Sorrell, Sammy Lap Ip Chan, Md. Arifur Rahim, Kourosh Kalantar-Zadeh

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Abstract

Eutectic alloys have long been investigated for their unique properties such as single point melting temperature, homogenous structures, and uniform distribution of phases. In this work, we synthesized and characterized two low melting temperature liquid metal alloys. Eutectic alloys of indium-tin-bismuth (Field's metal) and Field's metal-like alloy with traces of zinc (0.4 wt%) were studied through a series of structural, thermal, microstructural, and mechanical tests. The in vitro biocompatibility of the alloys was assessed to investigate their potential application as bioimplants. These low melting point alloys (∼62 °C and ∼60 °C for Field's metal and the alloy with zinc, respectively) were utilized to address one of the major issues faced by the conventional use of bioimplants, which is the invasive surgery. We provide a proof-of-concept utilizing the combination of induction heating with the Field's metal-based alloys with suitable melting points. The approach enabled a contactless melting and extraction for the non-invasive removal of the bioimplant mimic from a polymer matrix, that can be potentially translated to the human body. We believe that this approach will provide fundamental insights for future biomedical applications and the design of liquid metal based non-invasive implants.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Additive Manufacturing and 3D Printing Technologies · High Entropy Alloys Studies · Additive Manufacturing Materials and Processes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (57)

Show source-provided references
1. Liquid metals: fundamentals and applications in chemistry10.1039/C7CS00043J ↗
2. Emergence of liquid metals in nanotechnology10.1021/acsnano.9b04843 ↗
3. Recent progress on liquid metals and their applications
4. Emerging applications of liquid metals featuring surface oxides10.1021/am5043017 ↗
5. Preparations, characteristics and applications of the functional liquid metal materials10.1002/adem.201700781 ↗
6. A liquid metal reaction system for advanced material manufacturing10.1021/accountsmr.1c00101 ↗
7. Liquid-metal-enabled mechanical-energy-induced CO2 conversion
8. Liquid metal based flexible and implantable biosensors10.3390/bios10110170 ↗
9. Liquid metal-based route for synthesizing and tuning gas-sensing elements10.1021/acssensors.0c00233 ↗
10. Liquid metals for tuning gas sensitive layers10.1039/C9TC01544B ↗
11. Photolithography-enabled direct patterning of liquid metals10.1039/D0TC01466D ↗
12. Laser sintering of liquid metal nanoparticles for scalable manufacturing of soft and flexible electronics10.1021/acsami.8b08722 ↗
13. Photolithography-based patterning of liquid metal interconnects for monolithically integrated stretchable circuits10.1021/acsami.6b01896 ↗
14. Stretchable and soft electronics using liquid metals10.1002/adma.201606425 ↗
15. Bi-phasic Ag-In-Ga-embedded elastomer inks for digitally printed, ultra-stretchable, multi-layer electronics10.1021/acsami.0c22206 ↗
16. Liquid metals in catalysis for energy applications10.1016/j.joule.2020.10.012 ↗
17. Room temperature CO2 reduction to solid carbon species on liquid metals featuring atomically thin ceria interfaces10.1038/s41467-019-08824-8 ↗
18. Antibacterial liquid metals: biofilm treatment via magnetic activation10.1021/acsnano.9b07861 ↗
19. Gallium-based liquid metal particles for therapeutics10.1016/j.tibtech.2020.10.005 ↗
20. Electronic skins based on liquid metals10.1109/JPROC.2019.2908433 ↗
21. Liquid metal biomaterials: a newly emerging area to tackle modern biomedical challenges10.1080/09506608.2016.1271090 ↗
22. Enzyme-powered liquid metal nanobots endowed with multiple biomedical functions10.1021/acsnano.1c01573 ↗
23. A highly conductive and stretchable wearable liquid metal electronic skin for long-term conformable health monitoring10.1007/s11431-018-9253-9 ↗
24. Magnetic liquid metal loaded nano-in-micro spheres as fully flexible theranostic agents for SMART embolization10.1039/D1NR01268A ↗
25. Highly stretchable and biocompatible liquid metal-elastomer conductors for self-healing electronics10.1002/smll.202005336 ↗
26. Liquid-solid phase transition alloy as reversible and rapid molding bone cement10.1016/j.biomaterials.2014.08.048 ↗
27. Permeable superelastic liquid-metal fibre mat enables biocompatible and monolithic stretchable electronics10.1038/s41563-020-00902-3 ↗
28. Liquid metal nanocomposites10.1039/D0NA00148A ↗
29. Galvanic replacement of liquid metal/reduced graphene oxide frameworks
30. Light-driven liquid metal nanotransformers for biomedical theranostics10.1038/ncomms15432 ↗
31. Novel contrast media based on the liquid metal gallium for in vivo digestive tract radiography: a feasibility study10.1007/s10534-019-00212-5 ↗
32. Transformable liquid-metal nanomedicine10.1038/ncomms10066 ↗
33. Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy10.1007/s12274-018-2262-y ↗
34. Enhanced endosomal escape by light-fueled liquid-metal transformer10.1021/acs.nanolett.6b04346 ↗
35. Amorphous liquid metal electrodes enabled conformable electrochemical therapy of tumors10.1016/j.biomaterials.2017.09.006 ↗
36. Alternating-magnetic-field-mediated wireless manipulations of a liquid metal for therapeutic bioengineering10.1016/j.isci.2018.04.012 ↗
37. Advances in liquid metals for biomedical applications10.1039/C7CS00309A ↗
38. Alloying design of biodegradable zinc as promising bone implants for load-bearing applications10.1038/s41467-019-14153-7 ↗
39. Bioresorbable metals for biomedical applications: from mechanical components to electronic devices10.1002/adhm.202002236 ↗
40. A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: the unsolved challenge10.1302/2046-3758.73.BJR-2017-0270.R1 ↗
41. Metallic bone fixation implants: a novel design approach for reducing the stress shielding phenomenon10.1080/17452759.2017.1307769 ↗
42. State of the art of bioimplants manufacturing: part I10.1007/s40436-017-0207-4 ↗
43. Liquid metal biomaterials: a newly emerging area to tackle modern biomedical challenges10.1080/09506608.2016.1271090 ↗
44. Unique surface patterns emerging during solidification of liquid metal alloys10.1038/s41565-020-00835-7 ↗
45. Effect of 50 to 60°C heating on osseointegration of dental implants in dense bone: an: in vivo: histological study10.1097/ID.0000000000000162 ↗
46. Thermal dose requirement for tissue effect: experimental and clinical findings
47. On the virtue of indium in reduction reactions. a comparison of reductions mediated by indium and zinc: is indium metal an effective catalyst for zinc induced reductions?10.1002/ejic.201901081 ↗
48. Liquid metal core–shell structures functionalised via mechanical agitation: the example of Field's metal10.1039/C9TA05200C ↗
49. Thermodynamic optimization of the lead-free solder system Bi-In-Sn-Zn10.1016/S0925-8388(03)00325-6 ↗
50. American Society for Testing and Materials, Standard test methods for tension testing of metallic materials, West Conshohocken, PA: ASTM International (ASTM E8/E8M- 16a), 2016, doi:10.1520/E0008_E0008M-16A.10.1520/E0008_E0008M-16A ↗
51. Microstructure and mechanical properties of Sn-Bi, Sn-Ag and Sn-Zn lead-free solder alloys10.1016/j.jallcom.2013.03.234 ↗
52. Bone mechanical properties in healthy and diseased states10.1146/annurev-bioeng-062117-121139 ↗
53. Selection of extraction medium influences cytotoxicity of zinc and its alloys10.1016/j.actbio.2019.03.013 ↗
54. Long-term surveillance of zinc implant in murine artery: surprisingly steady biocorrosion rate10.1016/j.actbio.2017.05.045 ↗
55. Interfacial zinc phosphate is the key to controlling biocompatibility of metallic zinc implants10.1002/advs.201900112 ↗
56. Cytotoxicity of zinc in vitro10.1016/0009-2797(89)90085-9 ↗
57. The in vitro effects of metal cations on eukaryotic cell metabolism10.1002/jbm.820250907 ↗