Effect of mechanical loading on osseointegration combined with degradation behavior of magnesium bone screw in vivo
Source abstract
Abstract
Mechanical environment is one of the critical factors that affect the degradation and osseointegration performance of magnesium-based orthopedic implants. In this study, the effects of in vivo static and dynamic loadings on osseointegration and biodegradation behavior of magnesium screw were investigated and compared. A total of 54 male New Zealand White rabbits were divided into three groups randomly, with their femoral condyles implanted with high-purity magnesium screws (Implanted Group), only drilled holes (Drilled Group) or without any surgery (Healthy Group) respectively. Half of the rabbits in each group stayed in cages all the time (as static subgroup), while the rest performed treadmill exercise (as dynamic subgroup). Dynamic loadings during rabbits’ exercise were obtained based on kinematic analysis. Femoral condyles implanted with screws in Implanted Group were harvested at 8, 12 and 16 weeks after surgery to evaluate the biodegradation behavior and osseointegration. To compare the mechanical property of bone tissues, three femoral condyles of each subgroup in Implanted, Drilled, and Healthy groups were randomly selected to perform nanoindentation testing at 8, 12 and 16 weeks. Dynamic loading improved osseointegration performance obviously but did not affect the biodegradation behavior of magnesium screws. Elastic moduli of new-born bone surrounding magnesium bone screws were higher in the dynamic groups than that in static groups. Metabolism of released Mg ions from bone screw was normal both under static and dynamic loadings. The effects of mechanical loadings on osseointegration combined with degradation of magnesium screws in vivo were understood deeply in this study, providing guidance for patient's rehabilitative exercise postoperatively.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Orthopaedic implants and arthroplasty · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (65)
Show source-provided references
1. Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective10.1016/j.biomaterials.2016.10.017 ↗
2. Use of resorbable magnesium screws in children: systematic review of the literature and short-term follow- up from our series10.1302/1863-2548.15.210004 ↗
3. Improved in vivo osseointegration and degradation behavior of PEO surface-modified WE43 magnesium plates and screws after 6 and 12 months10.1016/j.msec.2021.112380 ↗
4. Calcium phosphate coatings enhance biocompatibility and degradation resistance of magnesium alloy: correlating in vitro and in vivo studies
5. Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits
6. High-purity weight-bearing magnesium screw: translational application in the healing of femoral neck fracture10.1016/j.biomaterials.2020.119829 ↗
7. Biodegradable metals for bone defect repair: a systematic review and meta-analysis based on animal studies
8. Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model10.1016/j.biomaterials.2020.119828 ↗
9. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats10.1038/nm.4162 ↗
10. High-purity magnesium pin enhances bone consolidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling
11. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head10.1016/j.biomaterials.2015.11.038 ↗
12. Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy10.1073/pnas.1518238113 ↗
13. In vitro evaluation of the ZX11 magnesium alloy as potential bone plate: degradability and mechanical integrity10.1016/j.actbio.2019.07.053 ↗
14. Biodegradable Magnesium-Based Implants in Orthopedics-A General Review and Perspectives10.1002/advs.201902443 ↗
15. Biomechanical study on implantable and interventional medical devices10.1007/s10409-021-01116-9 ↗
16. Review of recent developments in the field of magnesium corrosion10.1002/adem.201400434 ↗
17. Mg and its alloys for biomedical applications: exploring corrosion and its interplay with mechanical failure10.3390/met7070252 ↗
18. In vitro degradation kinetics of pure PLA and Mg/PLA composite: effects of immersion temperature and compression stress10.1016/j.actbio.2016.11.001 ↗
19. Degradation mechanism of magnesium alloy stent under simulated human micro-stress environment10.1016/j.msec.2017.12.001 ↗
20. Effects of nanofeatures induced by severe shot peening (SSP) on mechanical, corrosion and cytocompatibility properties of magnesium alloy AZ3110.1016/j.actbio.2017.11.032 ↗
21. Influence of strain on the corrosion of magnesium alloys and zinc in physiological environments10.1016/j.actbio.2016.10.030 ↗
22. A physical corrosion model for bioabsorbable metal stents10.1016/j.actbio.2013.12.059 ↗
23. A computational framework to model degradation of biocorrodible metal stents using an implicit finite element solver10.1007/s10439-015-1530-1 ↗
24. Computational modeling of the mechanical performance of a magnesium stent undergoing uniform and pitting corrosion in a remodeling artery
25. Continuum damage model for bioresorbable magnesium alloy devices — application to coronary stents10.1016/j.jmbbm.2010.11.003 ↗
26. A quantitative study on magnesium alloy stent biodegradation10.1016/j.jbiomech.2018.04.027 ↗
27. Effect of stress on corrosion of high-purity magnesium in vitro and in vivo10.1016/j.actbio.2018.11.019 ↗
28. Corrosion fatigue behaviors of two biomedical Mg alloys-AZ91D and WE43-In simulated body fluid10.1016/j.actbio.2010.07.026 ↗
29. Corrosion fatigue of a magnesium alloy under appropriate human physiological conditions for bio-implant applications10.1016/j.engfracmech.2017.09.031 ↗
30. The influence of alternating cyclic dynamic loads with different low frequencies on the bio-corrosion behaviors of AZ31B magnesium alloy in vitro
31. The Effects of Static and Dynamic Loading on Biodegradable Magnesium Pins In Vitro and In Vivo10.1038/s41598-017-14836-5 ↗
32. Effects of immediately static loading on osteointegration and osteogenesis around 3D-printed porous implant: a histological and biomechanical study10.1016/j.msec.2019.110406 ↗
33. A novel auxetic structure based bone screw design: tensile mechanical characterization and pullout fixation strength evaluation10.1016/j.matdes.2019.108424 ↗
34. Influence of Different Three-Dimensional Open Porous Titanium Scaffold Designs on Human Osteoblasts Behavior in Static and Dynamic Cell Investigations10.3390/ma8085259 ↗
35. Cancellous bone adaptation to in vivo loading in a rabbit model10.1016/j.bone.2005.11.026 ↗
36. Bone remodeling and mechanobiology around implants: insights from small animal imaging10.1002/jor.23758 ↗
37. MG-63 cell proliferation with static or dynamic compressive stimulation on an auxetic PLGA Scaffold10.1155/2017/1286109 ↗
38. MG-63 osteoblast-like cell proliferation on auxetic PLGA scaffold with mechanical stimulation for bone tissue regeneration
39. Analysis of factors influencing bone ingrowth into three-dimensional printed porous metal scaffolds: a review10.1016/j.jallcom.2017.05.079 ↗
40. Exercise training improves cardiac function in infarcted rabbits: involvement of autophagic function and fatty acid utilization10.1093/eurjhf/hfq028 ↗
41. Positive effects of cell-free porous PLGA implants and early loading exercise on hyaline cartilage regeneration in rabbits10.1016/j.actbio.2015.09.026 ↗
42. A dynamic finite element analysis of impulsive loading of the extension-splinted rabbit knee10.1115/1.2891162 ↗
43. Modeling and simulation of material degradation in biodegradable wound closure devices10.1002/jbm.b.33100 ↗
44. Spatial distribution and remodeling of elastic modulus of bone in micro-regime as prediction of early stage osteoporosis10.1016/j.jbiomech.2015.11.052 ↗
45. Changes in the mechanical properties and composition of bone during microdamage repair
46. Magnesium from bioresorbable implants: distribution and impact on the nano- and mineral structure of bone10.1016/j.biomaterials.2015.10.054 ↗
47. Anaerobic threshold employed on exercise training prescription and performance assessment for laboratory rodents: a short review10.1016/j.lfs.2016.02.016 ↗
48. Positive effects of cell-free porous PLGA implants and early loading exercise on hyaline cartilage regeneration in rabbits10.1016/j.actbio.2015.09.026 ↗
49. Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? A review10.1016/j.actbio.2014.11.048 ↗
50. Inflammatory response to magnesium-based biodegradable implant materials10.1016/j.actbio.2019.10.014 ↗
51. A critical review of the stress corrosion cracking (SCC) of magnesium alloys10.1002/adem.200500071 ↗
52. Elucidating the role of microstructural modification on stress corrosion cracking of biodegradable Mg-4Zn alloy in simulated body fluid10.1016/j.msec.2019.110164 ↗
53. Effect of strain on degradation behaviors of WE43, Fe and Zn wires10.1016/j.actbio.2020.06.028 ↗
54. Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo10.1002/jbm.b.32722 ↗
55. Corrosion Mechanisms of Magnesium Alloys10.1002/(SICI)1527-2648(199909)1:1<11::AID-ADEM11>3.0.CO;2-N ↗
56. Comparison of a resorbable magnesium implant in small and large growing-animal models10.1016/j.actbio.2018.07.044 ↗
57. Comparative study about degradation of high-purity magnesium screw in intact femoral intracondyle and in fixation of femoral intracondylar fracture10.1016/j.jmst.2016.04.013 ↗
58. Effects of external stress on biodegradable orthopedic materials: a review
59. Correlation of bony ingrowth to the distribution of stress and strain parameters surrounding a porous-coated implant10.1002/jor.1100140604 ↗
60. The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway10.1016/j.actbio.2019.06.001 ↗
61. Biodegradable magnesium alloys promote angio-osteogenesis to enhance bone repair10.1002/advs.202000800 ↗
62. Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur10.1016/S0021-9290(99)00111-6 ↗
63. Nanoindentation measurements of biomechanical properties in mature and newly formed bone tissue surrounding an implant10.1115/1.4005981 ↗
64. Assessment of composition and anisotropic elastic properties of secondary osteon lamellae10.1016/j.jbiomech.2005.07.009 ↗
65. Effect of microstructure on the mechanical properties of Haversian cortical bone10.1016/j.bone.2005.09.017 ↗