Hierarchically porous bioceramics based on geopolymer-hydroxyapatite composite as a novel biomaterial: Structure, mechanical properties and biocompatibility evaluation
Source abstract
Abstract
In this study, open-cell porous bioceramics based on geopolymers were synthesized by the replica technique. The composition consisted of a mixture of metakaolin (MK) and hydroxyapatite (HA) that combined are suitable for application in bone tissue engineering. Metakaolin is a cheap natural aluminosilicate known for its mechanical properties, while hydroxyapatite stands out for its biocompatibility due to the chemical structure similar to the bone matrix. After undergoing heat treatment (HT), the geopolymer-hydroxyapatite (GMK-HA) synthesized materials, referred to as GMK-HA-HT, presented pores in the range from 1 to 5 mm. In the compressive strength tests, they exhibited values between 1.18 and 2.9 MPa. These ranges of values signify a proper balance between mechanical strength and porosity. X-ray diffraction analysis showed phosphate and/or calcium crystalline phases in all heat-treated samples, indicating HA`s successful incorporation in the geopolymer structure. In vitro tests using human adipose-derived mesenchymal stem cells (ADSCs) were conducted to evaluate the biocompatibility of the synthesized materials. The extracts obtained from the GMK-HA-HT were found to be non-cytotoxic. ADSCs in contact with extracts have no morphological changes and when cultured on the GMK-HA-HT surface, the cells interacted with the scaffold and formed a monolayer. Here, for the first time, we provide insights into this new class of materials as a promising biomaterial candidate which could be associated with ADSCs to promote bone healing.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Dental materials and restorations
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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