journal article·2023-06

NIR-responsive GO/Ag2S heterostructure for rapid bacteria-killing and wound healing

Jingwen Wu, Tian Deng, Qian Wu, Yun Qiu, Yan Wei, Qin Zhao, Yufeng Zhang

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Abstract

Many efforts have been made to treat infections; however, it is difficult to treat bacterial infections effectively with a single antibacterial strategy. Therefore, it is imperative to develop drugs or materials with multiple synergistic mechanisms. Graphene oxide/silver sulfide (GO/Ag2S) heterostructure would become potential nano-antibiotics that display a synergistic photothermal/photodynamic antibacterial mechanism. The material was characterized with different tests, meanwhile, density functional theory (DFT), electrochemical tests, and electron paramagnetic resonance (EPR) were also tested. The heterostructure nanosheets showed significant therapy via effective photothermal/photodynamic conversion and displayed antibacterial activity against both gram-positive S. aureus and gram-negative E. coli. In addition, we found that GO/Ag2S heterostructure could disrupt the integrity of bacterial membranes and inhibit the growth of bacteria. We confirmed its antibacterial effects in subcutaneous abscess models as well. Therefore, GO/Ag2S heterostructure could be a viable alternative option for antibiotic development.
Source: expertdata · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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