Controllable synthesis of copper ion guided MIL-96 octadecahedron: highly sensitive aptasensor toward alpha-fetoprotein

Abstract MIL-96 with a controlled size and morphology, was successfully synthesized by an effective new method, in which copper ions were added as a guiding agent. In addition, the introduction of copper improves the conductivity of the material. Compared to traditional methods, this strategy is operationally easy and does not require the addition of large organic molecules in addition to the ligand. Among the series of as-prepared materials, the M2.5:2.5-based electrochemical aptasensor showed excellent sensitivity with a low limit of detection of 0.12 pg/mL, within a wide linear range of alpha-fetoprotein concentrations from 0.001 to 0.5 ng/mL, with good selectivity, repeatability, stability and applicability in real samples. This work development a new strategy for the controlled synthesis and modification of MOFs. In addition, this work provides a new platform for biosensing, enriching the application field of MOFs.