Additive manufacturing of electrochemical interfaces: Simultaneous detection of biomarkers
Source abstract
Abstract
Abstract 3D-printed stainless steel helical shaped electrodes with or without surface modification with a gold (Au) film are tested as novel electrode materials for the electrochemical detection of ascorbic acid and uric acid in aqueous solutions. Their performance in terms of sensitivity, selectivity and reproducibility is evaluated and compared to conventional glassy carbon electrode (GCE). Owing to the excellent electrocatalytic properties of the 3D-printed gold (Au) electrode, a clear separation between the anodic oxidation signal of ascorbic acid and uric acid in differential pulse voltammogram (DPV) could be obtained, allowing simultaneous quantification of these biomarkers. The oxidation current obtained using the 3D-printed Au electrode increased linearly with its respective biomarkers concentration in the range of 0.1–1 mM. Furthermore, the 3D-printed Au electrode generally performed better in terms of sensitivity and detection limits as compared to GCE. A real sample analysis of Vitamin C tablet (500 mg), Vitacimin was conducted using the 3D-printed Au electrode obtaining a variation from claimed concentration of ascorbic acid of only about 0.5%. Therefore, electrodes fabricated by 3D printing would certainly represent a viable alternative to conventional electrodes for efficient electrochemical analysis in the future.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Electrochemical Analysis and Applications · Analytical Chemistry and Sensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (43)
Show source-provided references
1. Solubility of ascorbic, 2-furancarboxylic, glutaric, pimelic, salicylic, and o-phthalic acids in water from 279.15 to 342.15K, and apparent molar volumes of ascorbic, glutaric, and pimelic acids in water at 298.15K10.1016/0021-9614(89)90161-4 ↗
2. Bioavailability of 2-O-alpha-d-glucopyranosyl-l-ascorbic acid as ascorbic acid in healthy humans10.1016/j.nut.2008.11.031 ↗
3. Glutathione ascorbic-acid antioxidant system in animals10.1016/S0021-9258(17)36891-6 ↗
4. Clinical manifestations of ascorbic acid deficiency in man10.1093/ajcn/24.4.432 ↗
5. Regulation of uric acid metabolism and excretion10.1016/j.ijcard.2015.08.109 ↗
6. Uric acid: a marker of increased cardiovascular risk10.1016/j.atherosclerosis.2008.05.022 ↗
7. Determination of ascorbic acid by electrochemical techniques and other methods
8. Synthesis of positively charged CdTe quantum dots and detection for uric acid10.1016/j.saa.2011.05.014 ↗
9. Chemometric-assisted kinetic-spectrophotometric method for simultaneous determination of ascorbic acid, uric acid, and dopamine10.1016/j.ab.2010.11.007 ↗
10. Sensitive electrochemical determination uric acid at Pt nanoparticles decorated graphene composites in the presence of dopamine and ascorbic acid10.20964/2016.06.54 ↗
11. Preparation and characterization of PtAu hybrid film modified electrodes and their use in simultaneous determination of dopamine, ascorbic acid and uric acid10.1016/j.talanta.2007.05.049 ↗
12. A limited anodic and cathodic potential window of MoS2: limitations in electrochemical applications10.1039/C4NR06899H ↗
13. A selective sensor based on a glassy carbon electrode modified with carbon nanotubes and ruthenium oxide/hexacyanoferrate film for simultaneous determination of ascorbic acid, epinephrine and uric acid10.1039/c1ay05305a ↗
14. Characterization of an ultrasensitive biosensor based on a nano-Au/DNA/nano-Au/poly(SFR) composite and its application in the simultaneous determination of dopamine, uric acid, guanine, and adenine10.1016/j.snb.2012.12.015 ↗
15. Electrochemical determination of ascorbic acid, dopamine and uric acid based on an exfoliated graphite paper electrode: a high performance flexible sensor10.1016/j.snb.2013.12.004 ↗
16. Voltammetric and amperometric behaviour of uric acid at bare and surface-modified screen-printed electrodes: studies towards a disposable uric acid sensor10.1039/an9921701299 ↗
17. A selective voltammetric method for uric acid detection at Nafion®-coated carbon paste electrodes10.1016/S0039-9140(98)00004-6 ↗
18. Electrochemical sensor based on nitrogen doped graphene: simultaneous determination of ascorbic acid, dopamine and uric acid10.1016/j.bios.2012.01.030 ↗
19. A facile electrochemical sensor based on reduced graphene oxide and Au nanoplates modified glassy carbon electrode for simultaneous detection of ascorbic acid, dopamine and uric acid10.1016/j.snb.2014.07.077 ↗
20. A novel ionic liquid functionalized graphene oxide supported gold nanoparticle composite film for sensitive electrochemical detection of dopamine10.1039/C6RA25627A ↗
21. Simultaneous determination of ascorbic acid, dopamine, uric acid and tryptophan on gold nanoparticles/overoxidized-polyimidazole composite modified glassy carbon electrode10.1016/j.aca.2012.06.045 ↗
22. Double-codified gold nanolabels for enhanced immunoanalysis10.1021/ac070357m ↗
23. Microchip capillary electrophoresis with a single-wall carbon nanotube/gold electrochemical detector for determination of aminophenols and neurotransmitters10.1007/s00604-005-0438-0 ↗
24. Gold nanoparticle-enhanced microchip capillary electrophoresis10.1021/ac015589e ↗
25. Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology10.1021/cr030698+ ↗
26. Electrocatalytic oxidation and simultaneous determination of uric acid and ascorbic acid on the gold nanoparticles-modified glassy carbon electrode10.1016/j.electacta.2008.04.054 ↗
27. Graphene and its electrochemistry – an update10.1039/C6CS00136J ↗
28. Simultaneous determination of l-ascorbic acid, dopamine and uric acid with gold nanoparticles–β-cyclodextrin–graphene-modified electrode by square wave voltammetry10.1016/j.talanta.2012.01.047 ↗
29. 3D-printing technologies for electrochemical applications10.1039/C5CS00714C ↗
30. DNA biosensing with 3D printing technology10.1039/C6AN02038K ↗
31. 3D-printed metal electrodes for heavy metals detection by anodic stripping voltammetry10.1002/elan.201700388 ↗
32. 3D-printed metal electrodes for electrochemical detection of phenols10.1016/j.apmt.2017.07.005 ↗
33. 3D printed electrodes for detection of nitroaromatic explosives and nerve agents10.1021/acs.analchem.7b01614 ↗
34. 3D-printed electrodes for sensing of biologically active molecules10.1002/elan.201700828 ↗
35. Helical 3D-printed metal electrodes as custom-shaped 3D platform for electrochemical devices10.1002/adfm.201503902 ↗
36. Self-contained polymer/metal 3D printed electrochemical platform for tailored water splitting
37. Sonovoltammetric behavior of ascorbic acid and dehydroascorbic acid at glassy carbon electrodes: analysis using pulsed sonovoltammetry10.1002/elan.1140080304 ↗
38. Elucidation of the biological redox chemistry of purines using electrochemical techniques10.1021/ed060p315 ↗
39. Simultaneous determination of dopamine, ascorbic acid, and uric acid using carbon ionic liquid electrode10.1016/j.ab.2006.09.008 ↗
40. A systematic approach to standard addition methods in instrumental analysis10.1021/ed057p703 ↗
41. The generalized standard addition method
42. Gold cleaning methods for electrochemical detection applications10.1016/j.mee.2008.11.045 ↗
43. Diffusion coefficients of ferri- and ferrocyanide ions in aqueous media, using twin-electrode thin-layer electrochemistry10.1021/ac50160a042 ↗