MoS2 Nanoclusters-based biomaterials for disease- impaired wound therapy

Abstract Disease-impaired wound healing is one of the most challenging issues clinically, which requires the migration, proliferation and differentiation of multiple types of skin cells, and overcomes the disease-associated problems. To achieve this goal, we set out to firstly synthesize MoS2 (MS) nanoclusters and then to incorporate them into sodium alginate (SA) hydrogel to prepare SA-MS hydrogel as a kind of MoS2 nanoclusters-based biomaterial. The prepared SA-MS hydrogel demonstrates porous microstructure and uniform distribution of Mo elements. The released Mo4+ ions from SA-MS hydrogel exhibit distinct effects on the promotion of the migration and proliferation of human dermal fibroblasts cells (HDFs), human umbilical vein endothelial cells (HUVECs) and human hair dermal papilla cells (HhDPCs) and significantly up-regulated the expression of specific genes in HUVECs and HhDPCs in vitro. SA-MS hydrogel has significant effect on promoting angiogenesis around the wound bed and regeneration of hair follicles of diabetes-impaired wound in C57BL/6 mice diabetic model in vivo by the released Mo4+ ions. Besides, SA-MS hydrogel successfully suppressed skin cancer and realized the skin cancer-impaired wound healing of melanoma-bearing nude mice by the excellent photothermal performance of SA-MS hydrogel in combination of the stimulatory effect of the released Mo4+ ions. Therefore, the prepared SA-MS hydrogel may be one of the promising candidates for disease-impaired wound healing and provides a broad prospect for the development of skin regeneration in the future. The prepared SA-MS hydrogel releases Mo4+ ions to promote the migration and proliferation of HDFs, HVUECs, and HhDPCs. Moreover, the released Mo4+ ions have a significantly promoted role for the diabetes-impaired wound healing and combine with the photothermal performance of the SA-MS hydrogel to affect the healing of skin cancer impaired wound. Eventually, achieve the role of wound healing by promoting angiogenesis and hair follicle regeneration at the wound bed. Therefore, SA-MS hydrogels have an excellent ability of promoting healing for disease-impaired wound.