journal article·2018-12

Pollen-inspired microparticles with strong adhesion for drug delivery

Yuetong Wang, Luoran Shang, Guopu Chen, Changmin Shao, Yuxiao Liu, Peihua Lu, Fei Rong, Yuanjin Zhao

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Abstract

Abstract Microparticles with strong adhesion property was presented as efficacious drug delivery systems. Here, inspired by natural pollen, polymer microparticles with surface textures and homogeneous size were fabricated through evaporation-induced interfacial instability of microfluidic droplets templates. The resultant particles exhibited controllable surface roughness and thus strong adhesion ability to the intestinal mucosa. Such particles were employed as novel drug carriers, which contributed to enhanced loading efficacy and controllable release kinetics, and were proved to increase therapeutic effectiveness through in vivo and in vitro tests, thus playing a potential role in sustained drug delivery, bioimaging, diagnostics, etc.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation · Nanomaterials and Printing Technologies · Pickering emulsions and particle stabilization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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