Osteoimmunomodulatory biomaterials: Engineering strategies, current progress, and future perspectives for bone regeneration
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Mesenchymal stem cell research · Bone Tissue Engineering Materials · Osteoarthritis Treatment and Mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 201910.1016/S2666-7568(21)00172-0 ↗
2. Kammerer A., Hartmann F.A., Nau C., Leiblein M., Schaible A., Neijhoft J., et al. The Impact of Defect Size on Bone Healing in Critical-Size Bone Defects Investigated on a Rat Femur Defect Model Comparing Two Treatment Methods. 2024;11(3):287, https://doi.org/10.3390/bioengineering11030287.10.3390/bioengineering11030287 ↗
3. Biomaterials for tissue engineered bone Scaffolds: a review
4. Mesenchymal Stem Cells, Bioactive Factors, and Scaffolds in Bone Repair: from Research Perspectives to Clinical Practice10.3390/cells10081925 ↗
5. Enoxaparin sodium bone cement plays an anti-inflammatory immunomodulatory role by inducing the polarization of M2 macrophages10.1186/s13018-023-03865-8 ↗
6. Novel composite bone cement modulates inflammatory response in vitro10.1038/s41598-025-93575-4 ↗
7. Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation
8. Host Response to Biomaterials for Cartilage Tissue Engineering: key to Remodeling10.3389/fbioe.2021.664592 ↗
9. Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity10.1088/1748-605X/ac5574 ↗
10. Potential effects of biomaterials on macrophage function and their signalling pathways10.1039/D3BM01213A ↗
11. Macrophages and Bone Remodeling10.1002/jbmr.4773 ↗
12. Macrophages in immunoregulation and therapeutics10.1038/s41392-023-01452-1 ↗
13. Macrophage polarization in bone implant repair: a review10.1016/j.tice.2023.102112 ↗
14. Biomaterial-based osteoimmunomodulatory strategies via the TLR4-NF-κB signaling pathway: a review
15. Tailoring surface stiffness to modulate senescent macrophage immunomodulation: implications for osteo-/angio-genesis in aged bone regeneration10.1016/j.bioadv.2024.214010 ↗
16. Multiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis10.1038/s41467-024-47189-5 ↗
17. Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration10.1126/sciadv.abf6654 ↗
18. Biomaterial Surface Hydrophobicity-Mediated Serum Protein Adsorption and Immune Responses10.1021/acsami.9b09900 ↗
19. Chirality Regulates Macrophage Polarization for Tissue Regeneration Through Bidirectionally Modulating WTAP-Mediated m6A Modification10.1002/sstr.202300412 ↗
20. Sequential activation of M1 and M2 phenotypes in macrophages by Mg degradation from Ti-Mg alloy for enhanced osteogenesis10.1186/s40824-022-00262-w ↗
21. Immunomodulatory Biomaterials: tailoring Surface Properties to Mitigate Foreign Body Reaction and Enhance Tissue Regeneration10.1002/adhm.202401253 ↗
22. Remote Activation of M2 Macrophage Polarization via Magneto-Mechanical Stimulation To Promote Osteointegration10.1021/acsbiomaterials.3c00080 ↗
23. Magnetic responsive hydroxyapatite scaffold modulated macrophage polarization through PPAR/JAK-STAT signaling and enhanced fatty acid metabolism10.1016/j.biomaterials.2023.122051 ↗
24. Photothermal regulation of macrophage polarization with 2D Ti3C2Tx MXene nanosheets for enhanced immunomodulatory osteogenesis10.1016/j.colcom.2023.100733 ↗
25. Regulation of Macrophage Polarization Through Periodic Photo-Thermal Treatment to Facilitate Osteogenesis10.1002/smll.202202691 ↗
26. An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration10.1186/s12951-021-00992-4 ↗
27. Peptide-based hydrogel for enhanced bone repair10.1016/j.matdes.2023.111862 ↗
28. 3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis
29. Bioactive Materials for Bone Regeneration: biomolecules and Delivery Systems10.1021/acsbiomaterials.3c00609 ↗
30. Advanced Immunomodulatory Biomaterials for Therapeutic Applications
31. Advanced strategies to thwart foreign body response to implantable devices10.1002/btm2.10300 ↗
32. Diez-Escudero A. A practical guide for evaluating the osteoimmunomodulatory properties of biomaterials10.1016/j.actbio.2021.05.038 ↗
33. Immunoporosis: role of Innate Immune Cells in Osteoporosis10.3389/fimmu.2021.687037 ↗
34. Osteoimmunomodulation for the development of advanced bone biomaterials10.1016/j.mattod.2015.11.004 ↗
35. Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation10.14348/molcells.2017.0225 ↗
36. RANKL biology: bone metabolism, the immune system, and beyond10.1186/s41232-019-0111-3 ↗
37. Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells10.1016/j.bbrc.2007.04.042 ↗
38. Fracture healing is accelerated in the absence of the adaptive immune system10.1002/jbmr.185 ↗
39. Cellular biology of fracture healing10.1002/jor.24170 ↗
40. Zhu S., Zhou J., Xie Z. The balance between helper T 17 and regulatory T cells in osteoimmunology and relevant research progress on bone tissue engineering. Immunity, inflammation and disease. 2024;12(9):e70011, https://doi.org/10.1002/iid3.70011.10.1002/iid3.70011 ↗
41. Alternative activation of macrophages10.1038/nri978 ↗
42. Monocyte and macrophage biology: an overview10.1016/j.semnephrol.2010.03.002 ↗
43. Mechanisms of Macrophage Plasticity in the Tumor Environment: manipulating Activation State to Improve Outcomes10.3389/fimmu.2021.642285 ↗
44. M1/M2 macrophages and their overlaps - myth or reality?10.1042/CS20220531 ↗
45. The markers to delineate different phenotypes of macrophages related to metabolic disorders
46. Determinants of Resident Tissue Macrophage Identity and Function10.1016/j.immuni.2020.05.014 ↗
47. Targeting macrophages: therapeutic approaches in cancer10.1038/nrd.2018.169 ↗
48. Hannoodee · 2024
49. The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives10.21037/sci-2022-038 ↗
50. Exosomes from M1-Polarized Macrophages Enhance Paclitaxel Antitumor Activity by Activating Macrophages-Mediated Inflammation10.7150/thno.30716 ↗
51. Macrophage activation and polarization: nomenclature and experimental guidelines10.1016/j.immuni.2014.06.008 ↗
52. Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors10.1007/s00441-022-03726-6 ↗
53. Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease10.1038/nri.2015.8 ↗
54. IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide10.1186/s13287-018-1102-z ↗
55. Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration10.3389/fimmu.2019.01954 ↗
56. CD169(+) macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair10.1016/j.biomaterials.2017.10.033 ↗
57. IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages10.1038/s41598-023-46237-2 ↗
58. Vunjak-Novakovic G. Macrophages modulate engineered human tissues for enhanced vascularization and healing10.1007/s10439-014-1156-8 ↗
59. Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation10.1016/j.fmre.2023.12.015 ↗
60. Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo10.1007/s10456-013-9381-6 ↗
61. Endothelial and macrophage interactions in the angiogenic niche10.1016/j.cytogfr.2024.07.005 ↗
62. Cai B., Lin D., Li Y., Wang L., Xie J., Dai T., et al. N2-Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: a Missing Piece of the Bone Regeneration Puzzle. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021;8(19):e2100584, https://doi.org/10.1002/advs.202100584.10.1002/advs.202100584 ↗
63. Neutrophils and NETs in modulating acute and chronic inflammation10.1182/blood-2018-11-844530 ↗
64. The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time10.1016/j.actbio.2021.04.052 ↗
65. Dendritic cell-mediated in vivo bone resorption10.4049/jimmunol.0903560 ↗
66. The Crosstalk between T Cells, B Cells, and Osteoclasts in Rheumatoid Arthritis10.3390/ijms25052688 ↗
67. Influence of Bone Substitutes on Mesenchymal Stromal Cells in an Inflammatory Microenvironment10.3390/ijms24010438 ↗
68. Interplay between biomaterials and the immune system: challenges and opportunities in regenerative medicine10.1016/j.actbio.2022.11.003 ↗
69. Whitaker · Immunomodulatory Biomaterials for Tissue Repair. Chemical reviews. · 2021 · 121 · 11305
70. The pathology of the foreign body reaction against biomaterials10.1002/jbm.a.35958 ↗
71. Biomimetic Tissue Engineering: tuning the Immune and Inflammatory Response to Implantable Biomaterials10.1002/adhm.201800490 ↗
72. Macrophages in Tissue Repair, Regeneration, and Fibrosis10.1016/j.immuni.2016.02.015 ↗
73. Unraveling the interplay between inflammation and stem cell mobilization or homing: implications for tissue repair and therapeutics10.4103/tcmj.tcmj_100_24 ↗
74. Origin and physiological roles of inflammation10.1038/nature07201 ↗
75. Nukavarapu SP. Biomaterial-directed cell behavior for tissue engineering
76. Foreign body reaction to biomaterials10.1016/j.smim.2007.11.004 ↗
77. Biomaterials: foreign Bodies or Tuners for the Immune Response?10.3390/ijms20030636 ↗
78. Engineering approaches to manipulate osteoclast behavior for bone regeneration
79. Divergent immune responses to synthetic and biological scaffolds10.1016/j.biomaterials.2018.11.002 ↗
80. Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine10.1002/btm2.10063 ↗
81. Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration10.1177/20417314211041428 ↗
82. Material stiffness influences the polarization state, function and migration mode of macrophages10.1016/j.actbio.2019.02.048 ↗
83. Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages10.1371/journal.pone.0145813 ↗
84. Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression10.1016/j.yexcr.2018.04.005 ↗
85. The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels10.1002/jbm.a.34104 ↗
86. Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: experimental studies in vitro and in rats10.1016/j.actbio.2019.02.004 ↗
87. Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway
88. Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D10.1038/s41467-019-11397-1 ↗
89. Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS10.1016/j.actbio.2018.12.019 ↗
90. The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo10.1088/1748-6041/6/1/015007 ↗
91. Uniform 40-µm-pore diameter precision templated scaffolds promote a pro-healing host response by extracellular vesicle immune communication10.1002/term.3160 ↗
92. Microporous structures on mineralized collagen mediate osteogenesis by modulating the osteo-immune response of macrophages
93. Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds10.1016/j.biomaterials.2013.02.065 ↗
94. Unsaturated polyurethane films grafted with enantiomeric polylysine promotes macrophage polarization to a M2 phenotype through PI3K/Akt1/mTOR axis10.1016/j.biomaterials.2020.120012 ↗
95. Evers · Single-Cell Mechanical Characterization of Human Macrophages · 2022 · 2
96. Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: unraveling the effect of 3-D structures on inflammation10.1016/j.actbio.2013.10.035 ↗
97. Pore size-mediated macrophage M1 to M2 transition affects osseointegration of 3D-printed PEEK scaffolds10.18063/ijb.755 ↗
98. DLP fabrication of HA scaffold with customized porous structures to regulate immune microenvironment and macrophage polarization for enhancing bone regeneration
99. Effect of hierarchical porous scaffold on osteoimmunomodulation and bone formation
100. Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering10.1016/j.biomaterials.2011.05.065 ↗