Natural polysaccharide based complex drug delivery system from microfluidic electrospray for wound healing
Source abstract
Abstract
Abstract Natural polysaccharides have a demonstrated value in drug encapsulation and delivery. Efforts in this area are focused on improving the performances of these biomaterials. In this study, we present a multicompartment polysaccharide core-shell microparticle to construct a sustainable dual-release system of active molecules for enhancing wound healing. These microparticles were generated utilizing a microfluidic electrospray approach, in which a mixture of cellulose nanocrystals (CNC) and vascular endothelial growth factor (VEGF) were employed as the cores, with doxycycline hydrochloride (DH) mixed alginate as the shells. The resultant multicompartment particles exhibited wonderful antibacterial properties inherited from the alginate shell, and angiogenesis properties from the CNC core after the shell disintegrated. It was demonstrated that these core-shell microparticles performed their outstanding capabilities in inhibiting inflammation, promoting granulation tissue formation, collagen deposition, and angiogenesis, thereby accelerating rodents’ wound healing. These findings support the great potential value of CNC/alginate core-shell microparticles based on the synergistic drug delivery strategy for orchestrating wound healing.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrohydrodynamics and Fluid Dynamics · Electrospun Nanofibers in Biomedical Applications · Advanced Cellulose Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
Show source-provided references
1. Cellulose nanocrystals: chemistry, self-assembly, and applications10.1021/cr900339w ↗
2. Advances in engineering hydrogels10.1126/science.aaf3627 ↗
3. Nanocelluloses: a new family of nature-based materials10.1002/anie.201001273 ↗
4. Cellulose nanomaterials in interfacial evaporators for desalination: a "natural" choice
5. Dynamic regimes of electrified liquid filaments10.1073/pnas.1801053115 ↗
6. Cellulose based materials for controlled release formulations of agrochemicals: a review of modifications and applications10.1016/j.jconrel.2019.11.004 ↗
7. Key advances in the chemical modification of nanocelluloses10.1039/C3CS60204D ↗
8. All-aqueous thin-film-flow-induced cell-based monolayers10.1021/acsami.9b06382 ↗
9. Ion-mediated gelation of aqueous suspensions of cellulose nanocrystals10.1021/acs.biomac.5b00701 ↗
10. Imaging biomaterial-tissue interactions10.1016/j.tibtech.2017.09.004 ↗
11. Cellulose nanomaterials-binding properties and applications: a review10.3390/molecules23102684 ↗
12. Cellulose-based nanomaterials for energy applications10.1002/smll.201702240 ↗
13. Natural cellulose derived nanocomposites as anodic materials for lithium-ion batteries10.1002/tcr.201900030 ↗
14. Advanced materials through assembly of nanocelluloses10.1002/adma.201703779 ↗
15. Heterogeneous acetylation of plant fibers into micro- and nanocelluloses for the synthesis of highly stretchable, tough, and water-resistant co-continuous filaments via wet-spinning10.1021/acsami.8b17790 ↗
16. Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications10.1016/j.biomaterials.2019.119706 ↗
17. Mineralization of pH-sensitive doxorubicin prodrug in ZIF-8 to enable targeted delivery to solid tumors10.1021/acs.analchem.0c02599 ↗
18. An electrospun fiber-covered stent with programmable dual drug release for endothelialization acceleration and lumen stenosis prevention10.1016/j.actbio.2019.06.008 ↗
19. Spontaneously regenerative tough hydrogels10.1002/anie.201904932 ↗
20. Biocompatible double-membrane hydrogels from cationic cellulose nanocrystals and anionic alginate as complexing drugs codelivery10.1021/acsami.6b00555 ↗
21. Sustainable dual release of antibiotic and growth factor from ph responsive uniform alginate composite microparticles to enhance wound healing10.1021/acsami.9b04750 ↗
22. Roll-to-roll fabrication of touch-responsive cellulose photonic laminates10.1038/s41467-018-07048-6 ↗
23. Multi-stimulus-responsive shape-memory polymer nanocomposite network cross-linked by cellulose nanocrystals10.1021/am5081056 ↗
24. Composite core-shell microparticles from microfluidics for synergistic drug delivery10.1007/s40843-016-5151-6 ↗
25. Advancements in microfluidics for nanoparticle separation10.1039/C6LC01045H ↗
26. Microfluidics for production of particles: mechanism, methodology, and applications
27. Cellulose/calcium phosphate hybrids: new materials for biomedical and environmental applications10.1016/j.ijbiomac.2019.01.130 ↗
28. Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications10.1016/j.carbpol.2019.01.020 ↗
29. On-demand droplet collection for capturing single cells
30. Hierarchical micro/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration10.1016/j.biomaterials.2019.119555 ↗
31. Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer
32. Larger stabilizing particles make stronger liquid marble
33. Graphene-based nanocomposites for neural tissue engineering10.3390/molecules24040658 ↗
34. Control of particle adsorption for stability of pickering emulsions in microfluidics10.1002/smll.201802902 ↗
35. Microfluidics-assisted osteogenesis: injectable stem cell-laden photocrosslinkable microspheres fabricated using microfluidics for rapid generation of osteogenic tissue constructs10.1002/adfm.201670110 ↗
36. Polymer-brush-grafted mesoporous silica nanoparticles for triggered drug delivery10.1002/cphc.201800018 ↗
37. The present and future role of microfluidics in biomedical research10.1038/nature13118 ↗
38. Pomegranate-structured electrosprayed microspheres for long-term controlled drug release10.1002/ppsc.201400199 ↗