Conductive biomaterials as nerve conduits: Recent advances and future challenges
Source abstract
Abstract
Abstract Millions of people around the world are in distress due to neurodegenerative disorders. There have been continued attempts to design biomaterial-based therapies for the regeneration of dysfunctional neural tissues, mainly damaged peripheral nerve and spinal cord. The development of nerve guidance channels, where the distal and proximal end of a damaged nerve is sutured to an artificial conduit, has been one main strategy to treat damaged nerves. Different types of biomaterials have been utilized for fabricating the functional nerve conduits with the capability to stimulate the cellular function. Due to their intrinsic electrical properties, conductive materials revealed promising features for promoting regeneration of peripheral nerve injuries. This review article aims to critically summarize the recent advances and challenges toward the development of nerve conduits based on conductive materials and their future clinical applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Neuroscience and Neural Engineering · Nerve injury and regeneration
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Biodegradable bisvinyl sulfonemethyl-crosslinked gelatin conduit promotes regeneration after peripheral nerve injury in adult rats10.1038/s41598-017-17792-2 ↗
2. 3D bio-printed scaffold-free nerve constructs with human gingiva-derived mesenchymal stem cells promote rat facial nerve regeneration
3. Biomaterials selection for neuroprosthetics10.1016/j.cobme.2018.05.003 ↗
4. Electrically conductive biodegradable polymer composite for nerve regeneration: electricity-stimulated neurite outgrowth and axon regeneration10.1111/j.1525-1594.2007.00335.x ↗
5. Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering10.1002/term.383 ↗
6. B. Li et al., "PRGD/PDLLA conduit potentiates rat sciatic nerve regeneration and the underlying molecular mechanism," vol. 55, pp. 44–53, 2015.10.1016/j.biomaterials.2015.03.028 ↗
7. Katirji · 2007 · 61
8. Tissue engineering of the peripheral nervous system10.1586/14737175.2014.887444 ↗
9. Evaluation methods as quality control in the generation of decellularized peripheral nerve allografts10.1088/1741-2552/aaa21a ↗
10. Histological assessment in peripheral nerve tissue engineering10.4103/1673-5374.141798 ↗
11. R. Gaudin, C. Knipfer, A. Henningsen, R. Smeets, M. Heiland, and T. Hadlock, "Approaches to peripheral nerve repair: generations of biomaterial conduits yielding to replacing autologous nerve grafts in craniomaxillofacial surgery," BioMed Res. Int., vol. 2016, 2016.10.1155/2016/3856262 ↗
12. Partially oxidized polyvinyl alcohol conduitfor peripheral nerve regeneration10.1038/s41598-017-19058-3 ↗
13. Tissue engineering; strategies, tissues, and biomaterials10.1080/02648725.2018.1430464 ↗
14. Chitosan in Biomedical Engineering: a Critical Review10.2174/1574888X13666180912142028 ↗
15. Agarose-based biomaterials for tissue engineering10.1016/j.carbpol.2018.01.060 ↗
16. Poloxamer-based stimuli-responsive biomaterials
17. A Novel Electroactive Agarose-Aniline Pentamer Platform as a Potential Candidate for Neural Tissue Engineering10.1038/s41598-017-17486-9 ↗
18. A facile route to the synthesis of anilinic electroactive colloidal hydrogels for neural tissue engineering applications10.1016/j.jcis.2018.01.044 ↗
19. A novel bio electro active alginate-aniline tetramer/agarose scaffold for tissue engineering: synthesis, characterization, drug release and cell culture study10.1080/09205063.2017.1340044 ↗
20. The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine10.1016/j.msec.2014.06.004 ↗
21. Conductive PPY/PDLLA conduit for peripheral nerve regeneration10.1016/j.biomaterials.2013.10.002 ↗
22. Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair: a randomized controlled trial10.1016/j.apmr.2009.01.019 ↗
23. Ultrasound-stimulated peripheral nerve regeneration within asymmetrically porous PLGA/Pluronic F127 nerve guide conduit10.1002/jbm.b.31659 ↗
24. Does pulsed magnetic field therapy influence nerve regeneration in the median nerve model of the rat?10.1155/2014/401760 ↗
25. Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells10.1073/pnas.91.8.3201 ↗
26. Can regenerative medicine and nanotechnology combine to heal wounds? The search for the ideal wound dressing10.2217/nnm-2017-0173 ↗
27. Biodegradable and electrically conducting polymers for biomedical applications10.1016/j.progpolymsci.2013.06.003 ↗
28. Polyaniline in retrospect and prospect
29. Electrically conductive polymers and composites for biomedical applications10.1039/C5RA01851J ↗
30. Emerging nanotechnology approaches in tissue engineering for peripheral nerve regeneration10.1016/j.nano.2010.07.004 ↗
31. Axon regeneration in the peripheral and central nervous systems10.1007/400_2009_19 ↗
32. Peripheral axon regrowth: new molecular approaches10.1016/j.neuroscience.2013.02.059 ↗
33. Prospects of peripheral nerve tissue engineering using nerve guide conduits based on silk fibroin protein and other biopolymers10.1080/09506608.2016.1252551 ↗
34. Silk fibroin scaffolds for common cartilage injuries: possibilities for future clinical applications10.1016/j.eurpolymj.2019.03.035 ↗
35. J. Scheib and A. Höke, "Advances in peripheral nerve regeneration," Nature Rev. Neurol. Rev. Article vol. 9, p. 668, 11/12/online 2013.10.1038/nrneurol.2013.227 ↗
36. Improving peripheral nerve regeneration: from molecular mechanisms to potential therapeutic targets10.1016/j.expneurol.2014.09.006 ↗
37. Electrical stimulation of somatic human stem cells mediated by composite containing conductive nanofibers for ligament regeneration10.1016/j.biologicals.2017.01.007 ↗
38. Alpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat
39. Chitosan nerve conduits seeded with autologous bone marrow mononuclear cells for 30mm goat peroneal nerve defect10.1038/srep44002 ↗
40. An in vivo study of tricalcium phosphate and glutaraldehyde crosslinking gelatin conduits in peripheral nerve repair
41. The effect of cerebrospinal fluid in collagen guide channel on sciatic nerve regeneration in rats
42. Construction of nerve guide conduits from cellulose/soy protein composite membranes combined with Schwann cells and pyrroloquinoline quinone for the repair of peripheral nerve defect10.1016/j.bbrc.2014.12.121 ↗
43. Bioactive poly (L-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration10.1016/S0142-9612(01)00190-9 ↗
44. Peripheral nerve regeneration using a microporous polylactic acid asymmetric conduit in a rabbit long-gap sciatic nerve transection model10.1016/j.biomaterials.2011.01.065 ↗
45. Peripheral nerve regeneration using composite poly (lactic acid‐caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning10.1002/jbm.a.32946 ↗
46. Poly-3-hydroxybutyrate (PHB): a resorbable conduit for long-gap repair in peripheral nerves10.1054/bjps.2002.3798 ↗
47. Scaffolds from block polyurethanes based on poly (ɛ-caprolactone)(PCL) and poly (ethylene glycol)(PEG) for peripheral nerve regeneration10.1016/j.biomaterials.2014.02.013 ↗
48. End-to-side neurorrhaphy using an electrospun PCL/collagen nerve conduit for complex peripheral motor nerve regeneration10.1016/j.biomaterials.2012.09.008 ↗
49. Ciliary neurotrophic factor‐coated polylactic‐polyglycolic acid chitosan nerve conduit promotes peripheral nerve regeneration in canine tibial nerve defect repair10.1002/jbm.b.31696 ↗
50. Laminin‐modified and aligned poly (3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)/polyethylene oxide nanofibrous nerve conduits promote peripheral nerve regeneration10.1002/term.2355 ↗
51. Regenerative potential of chitosan-coated poly-3-hydroxybutyrate conduits seeded with mesenchymal stem cells in a rat sciatic nerve injury model
52. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration10.1523/JNEUROSCI.20-07-02602.2000 ↗
53. Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat10.1038/srep22773 ↗
54. Enhanced cardiac differentiation of human cardiovascular disease patient-specific induced pluripotent stem cells by applying unidirectional electrical pulses using aligned electroactive nanofibrous scaffolds10.1021/acsami.6b15271 ↗
55. Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise10.1111/ejn.13005 ↗
56. Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering10.1002/term.383 ↗
57. Conductive polymers: towards a smart biomaterial for tissue engineering10.1016/j.actbio.2014.02.015 ↗
58. Short‐duration, DC electrical stimulation increases chick embryo DRG neurite outgrowth10.1002/bem.20214 ↗
59. Material properties and electrical stimulation regimens of polycaprolactone fumarate–polypyrrole scaffolds as potential conductive nerve conduits10.1016/j.actbio.2010.10.013 ↗
60. E. Doron-Mandel, M. Fainzilber, and M.J.F. l. Terenzio, "Growth control mechanisms in neuronal regeneration," vol. 589, no. 14, pp. 1669–1677, 2015.10.1016/j.febslet.2015.04.046 ↗
61. B. Song, M. Zhao, J. Forrester, and C.J.J. o. c. s. McCaig, "Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo," vol. 117, no. 20, pp. 4681–4690, 2004.10.1242/jcs.01341 ↗
62. M.E. Mycielska and M.B.J.J. o. c. s. Djamgoz, "Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease," vol. 117, no. 9, pp. 1631–1639, 2004.10.1242/jcs.01125 ↗
63. Q. Liu, B.J.T. i. j. o. b. Song, and c. biology, "Electric field regulated signaling pathways," vol. 55, pp. 264–268, 2014.10.1016/j.biocel.2014.09.014 ↗
64. R. Zhu, Z. Sun, C. Li, S. Ramakrishna, K. Chiu, and L.J.E.N. He, "Electrical stimulation affects neural stem cell fate and function in vitro," vol. 319, p. 112963, 2019.10.1016/j.expneurol.2019.112963 ↗
65. W.J. Choi et al., "Effects of substrate conductivity on cell morphogenesis and proliferation using tailored, atomic layer deposition-grown ZnO thin films," vol. 5, no. 1, pp. 1–9, 2015.10.1038/srep09974 ↗
66. F. Pires, Q. Ferreira, C.A. Rodrigues, J. Morgado, and F.C.J.B. e. B. A.-G. S. Ferreira, "Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering," vol. 1850, no. 6, pp. 1158–1168, 2015.10.1016/j.bbagen.2015.01.020 ↗
67. E. Ostrakhovitch, J. Byers, K. O'Neil, O.J.A. o. b. Semenikhin, and biophysics, "Directed differentiation of embryonic P19 cells and neural stem cells into neural lineage on conducting PEDOT–PEG and ITO glass substrates," vol. 528, no. 1, pp. 21–31, 2012.10.1016/j.abb.2012.08.006 ↗
68. S. Wang et al., "3D culture of neural stem cells within conductive PEDOT layer-assembled chitosan/gelatin scaffolds for neural tissue engineering," vol. 93, pp. 890–901, 2018.10.1016/j.msec.2018.08.054 ↗
69. S. Wang et al., "Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering," vol. 5, no. 10, pp. 2024–2034, 2017.10.1039/C7BM00633K ↗
70. H. Shao et al., "Carbon nanotube multilayered nanocomposites as multifunctional substrates for actuating neuronal differentiation and functions of neural stem cells," vol. 175, pp. 93–109, 2018.10.1016/j.biomaterials.2018.05.028 ↗
71. C.E. Schmidt, V.R. Shastri, J.P. Vacanti, and R.J.P. o. t. N. A. o. S. Langer, "Stimulation of neurite outgrowth using an electrically conducting polymer," vol. 94, no. 17, pp. 8948–8953, 1997.10.1073/pnas.94.17.8948 ↗
72. W.J. Parak, M. George, M. Kudera, H.E. Gaub, and J.C.J.E.B.J. Behrends, "Effects of semiconductor substrate and glia-free culture on the development of voltage-dependent currents in rat striatal neurones," vol. 29, no. 8, pp. 607–620, 2001.10.1007/s002490000109 ↗
73. Broad family of carbon nanoallotropes: classification, chemistry, and applications of fullerenes, carbon dots, nanotubes, graphene, nanodiamonds, and combined superstructures10.1021/cr500304f ↗
74. A Review on the Biocompatibility and Potential Applications of Graphene in Inducing Cell Differentiation and Tissue Regeneration
75. Engineering the niche for hair regeneration–a critical review
76. Skin care and rejuvenation by cosmeceutical facial mask10.1111/jocd.12730 ↗
77. Graphene-based nanomaterials for drug delivery and tissue engineering10.1016/j.jconrel.2013.10.017 ↗
78. V.B. Mohan, K.-t. Lau, D. Hui, and D.J.C.P.B. E. Bhattacharyya, "Graphene-based materials and their composites: a review on production, applications and product limitations," vol. 142, pp. 200–220, 2018.10.1016/j.compositesb.2018.01.013 ↗
79. An integrated multi-layer 3D-fabrication of PDA/RGD coated graphene loaded PCL nanoscaffold for peripheral nerve restoration10.1038/s41467-017-02598-7 ↗
80. 3D fabrication with integration molding of a graphene oxide/polycaprolactone nanoscaffold for neurite regeneration and angiogenesis
81. Three-dimensional self-assembly of graphene oxide and DNA into multifunctional hydrogels10.1021/nn1027104 ↗
82. Theranostic platforms proposed for cancerous stem cells: a review10.2174/1574888X13666181002152247 ↗
83. Graphene Based Materials in Neural Tissue Regeneration
84. Y. Kang et al., "Graphene oxide and reduced graphene oxide induced neural pheochromocytoma-derived PC12 cell lines apoptosis and cell cycle alterations via the ERK signaling pathways," vol. 12, p. 5501, 2017.10.2147/IJN.S141032 ↗
85. D. Convertino et al., "Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes," 2020.10.1021/acs.nanolett.0c00571 ↗
86. N.P. Pampaloni et al., "Single-layer graphene modulates neuronal communication and augments membrane ion currents," vol. 13, no. 8, pp. 755–764, 2018.10.1038/s41565-018-0163-6 ↗
87. Effects of electrical stimulation on peripheral nerve regeneration10.1016/j.biomed.2011.10.006 ↗
88. Stimulation of rat sciatic nerve regeneration with pulsed electromagnetic fields10.1016/0006-8993(89)90575-1 ↗
89. N.G. Shang et al., "Catalyst‐free efficient growth, orientation and biosensing properties of multilayer graphene nanoflake films with sharp edge planes," vol. 18, no. 21, pp. 3506–3514, 2008.10.1002/adfm.200800951 ↗
90. S.Y. Park et al., "Enhanced differentiation of human neural stem cells into neurons on graphene," vol. 23, no. 36, pp. H263–H267, 2011.10.1002/adma.201101503 ↗
91. D. Convertino, S. Luin, L. Marchetti, and C.J.F. i. n. Coletti, "Peripheral neuron survival and outgrowth on graphene," vol. 12, p. 1, 2018.10.3389/fnins.2018.00001 ↗
92. R. Guo et al., "Accelerating bioelectric functional development of neural stem cells by graphene coupling: implications for neural interfacing with conductive materials," vol. 106, pp. 193–204, 2016.10.1016/j.biomaterials.2016.08.019 ↗
93. O. Akhavan, E. Ghaderi, S.A.J.C. Shirazian, and S.B. Biointerfaces, "Near infrared laser stimulation of human neural stem cells into neurons on graphene nanomesh semiconductors," vol. 126, pp. 313–321, 2015.10.1016/j.colsurfb.2014.12.027 ↗
94. M. Tang, Q. Song, N. Li, Z. Jiang, R. Huang, and G.J.B. Cheng, "Enhancement of electrical signaling in neural networks on graphene films," vol. 34, no. 27, pp. 6402–6411, 2013.10.1016/j.biomaterials.2013.05.024 ↗
95. Biocompatibility of graphene oxide, Nanoscale Res
96. A. Raslan, L.S. del Burgo, J. Ciriza, and J.L.J.I.J. o. P. Pedraz, "Graphene oxide and reduced graphene oxide-based scaffolds in regenerative medicine," p. 119226, 2020.10.1016/j.ijpharm.2020.119226 ↗
97. T.-.H. Lee, C.-.T. Yen, S.-H. J.A.B. S. Hsu, and Engineering, "Preparation of polyurethane-graphene nanocomposite and evaluation of neurovascular regeneration," vol. 6, no. 1, pp. 597–609, 2019.10.1021/acsbiomaterials.9b01473 ↗
98. A three-layered hollow tubular scaffold as an enhancement of nerve regeneration potential10.1088/1748-605X/aad8da ↗
99. A new electrospun graphene-silk fibroin composite scaffolds for guiding Schwann cells10.1080/09205063.2017.1386835 ↗
100. In vitro and in vivo studies of electroactive reduced graphene oxide-modified nanofiber scaffolds for peripheral nerve regeneration