A hydrodynamic method for the measurement of Laponite-RD caffeine binding
Source abstract
Abstract
Abstract A novel flow-based technique to determine effective binding constants between caffeine and dispersed Laponite-RD particles in aqueous dispersions is presented. The technique, which is based on wide-bore hydrodynamic chromatography principles, exploits diffusion coefficient and flow profile differences between caffeine and Laponite-RD. A high-pressure liquid chromatography pump is used to create a laminar flow of mobile phase through a 0.25 mm diameter capillary; flow conditions are optimized in the capillary to exploit differences in diffusion coefficients of the dispersed Laponite-RD particles and caffeine. Different flow profiles for Laponite-RD and caffeine result enabling a deconvolution algorithm to determine the concentrations of caffeine associated with the Laponite-RD, a model nanoparticle, as well as the caffeine free in solution. Using these data, binding isotherms are presented from which an effective binding constant of caffeine associated with Laponite-RD can be obtained.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Microfluidic and Capillary Electrophoresis Applications · Analytical Chemistry and Chromatography · Nanopore and Nanochannel Transport Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (39)
Show source-provided references
1. Laminar dispersion in capillaries: Part I. Mathematical analysis10.1002/aic.690110620 ↗
2. Viscosity and transient electric birefringence study of clay colloidal aggregation10.1103/PhysRevE.65.021407 ↗
3. Baseline studies of the Clay Minerals Society Source Clays: cation exchange capacity measurements by the ammonia-electrode method10.1346/CCMN.2001.0490510 ↗
4. Caffeine, an anthropogenic marker for wastewater contamination of surface waters10.1021/es020125z ↗
5. Transition metal modified and partially calcined inorganic–organic pillared clays for the adsorption of salicylic acid, clofibric acid, carbamazepine, and caffeine from water10.1016/j.jcis.2012.07.037 ↗
6. Caulfield · 2008
7. Carbon nanotubule membranes for electrochemical energy storage and production10.1038/30694 ↗
8. Determination of caffeine as a tracer of sewage effluent in natural waters by on-line solid-phase extraction and liquid chromatography with diode-array detection10.1016/S0043-1354(02)00221-X ↗
9. Environmental risks of nanotechnology: national nanotechnology initiative funding, 2000–2004
10. Impact of nanotechnology on drug delivery10.1021/nn900002m ↗
11. Analysis of colloids: VII. Wide-bore hydrodynamic chromatography, a simple method for the determination of particle size in the nanometer size regime10.1016/0021-9673(94)00962-7 ↗
12. Apparent dissociation constants of some possible uracil metabolites of methylxanthines10.1080/00032718308065160 ↗
13. Solute distribution coupled with laminar flow in wide-bore capillaries: what can be separated without chemical or physical fields?10.2116/analsci.21.491 ↗
14. Caffeine as an indicator for the quantification of untreated wastewater in karst systems10.1016/j.watres.2011.11.003 ↗
15. Nanoparticles — known and unknown health risks10.1186/1477-3155-2-12 ↗
16. Itraconazole–Laponite: kinetics and mechanism of drug release10.1016/j.clay.2007.09.002 ↗
17. Caffeine as an anthropogenic marker of domestic waste: a study from Lake Simcoe watershed10.1016/j.ecolind.2012.05.001 ↗
18. Effects of laponite and silica nanoparticles on the cleaning performance of amylase towards starch soils10.1016/j.partic.2009.09.001 ↗
19. Analytical methods to assess nanoparticle toxicity10.1039/b818082b ↗
20. Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?10.1016/j.envint.2006.06.014 ↗
21. Solid lipid nanoparticles (sln) for controlled drug delivery — a review of the state of the art10.1016/S0939-6411(00)00087-4 ↗
22. Molecular weight sensing of polyethylene glycols by flow injection analysis and refractive index gradient detection10.1016/S0003-2670(00)80681-9 ↗
23. Structure of gels and aggregates of disk-like colloids10.1007/s101890170077 ↗
24. The surface energies of cation substituted Laponite10.1180/claymin.1993.028.1.01 ↗
25. Resolution of small molecules by passage through an open capillary10.1021/ac050715q ↗
26. Intercalation and release of antiinflammatory drug diclofenac into nanosized znal hydrotalcite-like compound10.1016/j.clay.2010.06.028 ↗
27. Occurrence and concentration of caffeine in Oregon coastal waters10.1016/j.marpolbul.2012.04.015 ↗
28. Caffeine in Boston harbor seawater10.1016/S0025-326X(00)00176-4 ↗
29. Separation of submicrometer particles by capillary hydrodynamic fractionation (chdf)10.1016/0021-9797(89)90073-8 ↗
30. Somasundaran · 2006 · vol. I
31. Study of natural clay adsorbent sepiolite for the removal of caffeine from aqueous solutions: batch and fixed-be column operation10.1007/s11270-013-1466-8 ↗
32. Southern Clay Products Inc.
33. The nature of laponite and its aqueous dispersions10.1016/0021-9797(92)90254-J ↗
34. Hydrodynamic chromatography of macromolecules in open microcapillary tubes10.1021/ac00127a030 ↗
35. Wide-bore hydrodynamic chromatography in sub-second range10.1002/jssc.200800504 ↗
36. Laminar dispersion in flow-injection analysis10.1016/0039-9140(81)80131-2 ↗
37. Surface-catalyzed transformations of aqueous endosulfan10.1021/es0256257 ↗
38. Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea10.1016/S0048-9697(02)00064-5 ↗
39. Engineered nanoparticles as precise drug delivery systems10.1002/jcb.20796 ↗