Use of an ion-exchange adduct of synthetic hectorite and chiral copper(II) complex as a packing material for chromatographic resolution
Source abstract
Abstract
A spherically shaped particle of synthetic hectorite (denoted as Na-HEC) was ion-exchanged with a divalent Cu(II) complex, [Cu( SS-oxa)] 2+ ( SS-oxa = SS-2,2′-isopropylidene-bis(4-phenyl-2-oxazoline)). The material is denoted as [Cu( SS-oxa)] 2+ /HEC. A column for high performance liquid chromatography (HPLC) was prepared by packing 4.0 g of [Cu( SS-oxa)] 2+/HEC into a stainless tube (25 cm × 0.4 cm (i.d.)). When tris(acetylacetonato)cobalt(III) (denoted as [Co(acac) 3 ]) was eluted by methanol at the flow rate of 0.2 mLmin −1 and 4 °C, the compound was separated to Δ- and Λ-enantiomers nearly to the baseline separation. Organic molecules with two hydroxyl groups such as 1,1′-binaphthyl-2,2′-diol were also resolved partially. The results promised the practical utility of the clay column chromatography for obtaining enantiomeric compounds.
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Research context
OpenAlex topics: Analytical Chemistry and Chromatography · Microfluidic and Capillary Electrophoresis Applications · Analytical chemistry methods development
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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