Tamoxifen/montmorillonite system – Effect of the experimental conditions
Source abstract
Abstract
A new nano system based on drug/clay minerals is sought as an alternative to the current options due to the limitations of the conventional treatment. In this study, experimental conditions, such as pH, reaction duration and initial drug concentration, were evaluated to obtain systems based on the anticancer drug tamoxifen (TMX) and montmorillonite. Equilibrium and kinetic studies were developed for montmorillonite (VHS)/TMX at pH values in the range of 1.5 to 7.0 for reaction times of 1 to 720 min and drug concentrations of 533 to 2300 mg·L. The solids were characterized by using X-ray diffraction and middle infrared spectroscopy (MID). The interaction of TMX with montmorillonite was pH-dependent with a higher adsorption at pH 5.5 (402.63 mg·g). For all pH values, intercalation of the drug was the preponderant mechanism of interaction. The system was described by a pseudo-second-order model. In the equilibrium study, the data adsorption was fitted to Langmuir model. Therefore, the reaction between TMX and montmorillonite was effective, and the best experimental conditions to obtain the studied hybrids were at pH 5.5 for 720 min and 2300 mg·L drug concentration.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Clay minerals and soil interactions · Layered Double Hydroxides Synthesis and Applications · Adsorption and biosorption for pollutant removal
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
Show source-provided references
1. Influence of dispersion conditions of two pharmaceutical grade clays on their interaction with some tetracyclines10.1016/j.clay.2005.03.007 ↗
2. Solid state characterisation of silver sulfadiazine loaded on montmorillonite/chitosan nanocomposite for wound healing10.1016/j.colsurfb.2013.08.043 ↗
3. Acid-modified montmorillonite for sorption of heavy metals from automobile effluent
4. Investigation of adsorption of 5-Chlorouracil onto montmorillonite: an IR and Raman spectroscopic study
5. High performance hydroxyiron modified montmorillonite nanoclay adsorbent for arsenite removal10.1016/j.cej.2017.10.031 ↗
6. A study of the molecular conformations and the vibrational, 1 H and 13 C NMR spectra of the anticancer drug tamoxifen and triphenylethylene10.1016/j.molstruc.2016.03.042 ↗
7. Biopharmaceutical improvement of praziquantel by interaction with montmorillonite and sepiolite
8. Effects of complexation between organic matter (OM) and clay mineral on OM pyrolysis10.1016/j.gca.2017.04.045 ↗
9. Clay-biosurfactant materials as functional drug delivery systems: slowing down effect in the in vitro release of cinnamic acid10.1016/j.clay.2016.10.039 ↗
10. Adsorption and characterization of palygorskite-isoniazid nanohybrids10.1016/j.clay.2017.12.027 ↗
11. Tramadol hydrochloride/montmorillonite composite: Preparation and controlled drug release10.1016/j.clay.2010.04.011 ↗
12. Effect of layer charges on exfoliation of montmorillonite in aqueous solutions10.1016/j.colsurfa.2018.03.066 ↗
13. Application of Elovich equation to the kinetics of phosphate release and sorption in soils110.2136/sssaj1980.03615995004400020013x ↗
14. Endometrial pathologies associated with postmenopausal tamoxifen treatment10.1016/j.ygyno.2004.03.048 ↗
15. Extended-release of chlorpromazine intercalated into montmorillonite clays10.1016/j.micromeso.2018.03.017 ↗
16. Theory of adsorption from solutions of non electrolytes on solid (I) Equation adsorption from solutions and the analysis of its simplest form, (II) Verification of the equation of adsorption isotherm from solutions
17. Montmorillonite-alginate beads: Natural mineral and biopolymers based sorbent of paraquat herbicides10.1016/j.jece.2017.11.018 ↗
18. Investigation of the initial stages of the montmorillonite acid-activation process using DFT calculations10.1016/j.clay.2018.08.012 ↗
19. Uber die adsorption in losungen
20. Pseudo-second order model for sorption processes10.1016/S0032-9592(98)00112-5 ↗
21. Hybrid materials based on montmorillonite and citostatic drugs: Preparation and characterization10.1016/j.clay.2011.01.031 ↗
22. Additive hormonal therapy in women with advanced breast cancer10.1002/1097-0142(19840201)53:3+<766::AID-CNCR2820531327>3.0.CO;2-H ↗
23. The removal of fluoride from aqueous solution by a lateritic soil adsorption: Kinetic and equilibrium studies10.1016/j.ecoenv.2017.11.016 ↗
24. Jalil · 2015 · vol. 114 · 69
25. Montmorillonite intercalated with vitamin B1as drug carrier10.1016/j.clay.2009.06.001 ↗
26. Effect of acid and alkali treatments on surface áreas and adsorption energies of selected minerals10.1346/000986002762090308 ↗
27. Montmorillonite/poly-(−caprolactone) composites as versatile layered material: Reservoirs for anticancer drug and controlled release property10.1016/j.ejps.2012.04.009 ↗
28. Spectroscopic studies of synthetic and natural beidellites: a review10.1016/j.clay.2005.10.003 ↗
29. Zur theorie der sogenannten adsorption geloster kungliga svenska vetenskapsakdemiens
30. Theoretical Calculation of UV-Vis, IR Spectra and Reactivity Properties of Tamoxifen Drug: a Methodology Comparison
31. The constitution and fundamental properties of solids and liquids. Part I. Solids10.1021/ja02268a002 ↗
32. Adsorption of levofloxacin onto an iron-pillared montmorillonite (clay mineral): Kinetics, equilibrium and mechanism10.1016/j.clay.2015.10.010 ↗
33. Preparation and characterization of organo-vermiculite based on phosphatidylcholine and adsorption of two typical antibiotics10.1016/j.clay.2016.12.002 ↗
34. Near-infrared spectroscopy: a powerful tool in studies of acid-treated clay minerals10.1016/j.vibspec.2008.08.001 ↗
35. The Elovich equation in chemisorption kinetics10.1038/2161204a0 ↗
36. Hybrid systems based on “drug – in cyclodextrin – in nanoclays” for improving oxaprozin dissolution properties10.1016/j.ijpharm.2016.05.028 ↗
37. Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine10.1016/j.msec.2017.03.044 ↗
38. The effect of acid treatment on the structure and surface acidity of tetraalkylammonium-montmorillonites10.1016/j.jcis.2012.12.027 ↗
39. Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer10.1016/j.ijbiomac.2014.08.012 ↗
40. Association between endometrial cancer and tamoxifen treatment of breast cancer10.1023/A:1006126411210 ↗
41. Chitosan-based nanoparticles for tumor-targeted drug delivery10.1016/j.ijbiomac.2014.10.052 ↗
42. Modeling of adsorption kinetic and equilibrium isotherms of naproxen onto functionalized nano-clay composite adsorbent10.1016/j.molliq.2016.10.059 ↗
43. Characterisation, in vitro release study, and antibacterial activity of montmorillonite-gentamicin complex material10.1016/j.msec.2016.09.031 ↗
44. Vibrational spectroscopy of acid treated vermiculites10.1016/j.vibspec.2013.11.007 ↗
45. Montmorillonite-chitosan-silver sulfadiazine nanocomposites for topical treatment of chronic skin lesions: in vitro biocompatibility, antibacterial efficacy and gap closure cell motility properties10.1016/j.carbpol.2013.10.029 ↗
46. Acid-leached mixed vermiculites obtained by treatment with nitric acid10.1016/j.clay.2014.12.008 ↗
47. Controlled release of metformin from chitosan–based nanocomposite films containing mesoporous MCM-41 nanoparticles as novel drug delivery systems10.1016/j.jcis.2017.04.036 ↗
48. Alteration of swelling clay minerals by acid activation10.1016/j.clay.2009.02.002 ↗
49. The kinetics of some industrial heterogeneous catalytic reactions10.1016/S0360-0564(08)60135-2 ↗
50. Chitosan-palmitic acid based polymeric micelles as promising carrier for circumventing pharmacokinetic and drug delivery concerns of tamoxifen10.1016/j.ijbiomac.2017.05.016 ↗
51. Surface and interface properties of benzethonium chloride-montmorillonite10.1016/j.colsurfa.2017.02.019 ↗
52. pH-responsive drug delivery of chitosan nanoparticles as Tamoxifen carriers for effective anti-tumor activity in breast cancer cells10.1016/j.colsurfb.2013.05.018 ↗
53. Smart montmorillonite-polypyrrole scaffolds for electro-responsive drug release10.1016/j.clay.2016.05.004 ↗
54. Adsorption of the quinolone antibiotic nalidixic acid onto montmorillonite and kaolinite10.1016/j.clay.2012.09.026 ↗