Investigation of adsorption of 5-Chlorouracil onto montmorillonite: An IR and Raman spectroscopic study
Source abstract
Abstract
Abstract In this study, the adsorption of 5-Chlorouracil (5-ClU) on natural montmorillonite from Anatolia was investigated using FT-IR and Raman spectroscopy. The 5-ClU is a thymine antagonist and has some antitumor properties. The comparison of the vibrational spectra of the adsorbed 5-ClU with those of the free molecule provided data on the nature and characteristics of the clay organic complexes. The intercalation of 5-ClU within montmorillonite has been shown by X-ray diffraction to increase the interlayer spacing. Vibrational spectroscopy indicates that adsorbed 5-ClU molecules on montmorillonite are coordinated to exchangeable cations, directly or indirectly through water bridges.
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Research context
OpenAlex topics: Clay minerals and soil interactions
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References (23)
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1. Adsorption and interaction of 5-fluorouracil with montmorillonite and saponite, by FTIR spectroscopy10.1016/j.molstruc.2006.11.061 ↗
2. Investigation of adsorption of 5-bromouracil from aqueous solutions to montmorillonite and its interaction with clay framework: a FT-IR spectroscopic study
3. 1991 · vol. 5
4. Adsorption of nucleic acid bases on clays: an investigation using Langmuir and Freundlich isotherms and FT-IR spectroscopy10.1007/s00706-008-0862-z ↗
5. Ar-matrix IR spectra of 5-halouracils interpreted by means of DFT calculations10.1021/jp045213f ↗
6. Laponite as carrier for controlled in vitro delivery of dexamethasone in vitreous humor models10.1016/j.ejpb.2016.08.015 ↗
7. Effect of the microhydration on the tautomerism in the anticarcinogenic drug 5-fluorouracil and relationships with other 5-haloderivatives10.1016/j.molstruc.2013.09.008 ↗
8. Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue10.1074/jbc.M303928200 ↗
9. Montmorillonite nanoclay as a multifaceted drug-delivery carrier: a review10.1016/j.jddst.2017.03.023 ↗
10. 5-Chlorouracil: a marker of DNA damage from hypochlorous acid during inflammation—a gas chromatography–mass spectrometry assay10.1074/jbc.M304021200 ↗
11. Synthesis of 5-chloro-1-(2,3-dideoxy-3-fluoro-beta-d-glycero-hex-2-enopyranose-4-ulosyl)uracil as potential anticancer/antiviral agent10.1081/NCN-100002424 ↗
12. Theoretical studies of 5-fluorouracil and 5-chlorouracil
13. Instability and decay of the primary structure of DNA10.1038/362709a0 ↗
14. Relative stability of keto-enol tautomers in 5,6-substituted uracils: ab initio, DFT and PCM study10.1016/j.comptc.2013.09.005 ↗
15. FTIR techniques in clay mineral studies10.1016/S0924-2031(02)00065-6 ↗
16. Synthesis, characterization and antitumour activity of 5-chlorouracil and 5-chlorouracil-histidine complexes with some metal(III) ions10.1080/00945719809351652 ↗
17. Simulation of a tetramer form of 5-chlorouracil: the vibrational spectra and molecular structure in the isolated and in the solid state by using DFT calculations10.1016/j.saa.2013.03.018 ↗
18. Transition metal complexes of 5-chlorouracil10.1007/BF01041499 ↗
19. X-ray-diffraction studies on 5-chlorouracil complexes with cobalt (II) and nickel (II)10.1002/crat.2170240823 ↗
20. Relationship between the mutagenic and base-stacking properties of halogenated uracil derivatives: the crystal structures of 5-chloro- and 5-bromouracil10.1016/0005-2787(75)90130-6 ↗
21. Room temperature fluorescence of 5-chlorouracil tautomers10.1016/0009-2614(95)00294-E ↗
22. Theng · 1974
23. Vibrational spectra of 5-halogenouracils: part I10.1016/S0022-2860(96)09499-9 ↗