journal article·2017-07

New opportunities for drug delivery carrier of natural allophane nanoparticles on human lung cancer A549 cells

Yusuke Toyota, Masami Okamoto, Shuichi Arakawa

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Abstract

Abstract The complexation of allophane nanoparticles with cisplatin, cis-dichlorodiammineplatinum (II) (CDDP) to deliver platinum prodrug into cancer cells was investigated. Using human lung carcinoma (A549) cells, profound studies including cellular uptake (endocytosis) analysis of allophane nanoparticle, cell cycle arrest abilities and apoptosis induction profiles were discussed in detail. As well as the features against A549 cells to emerge a promising strategy to enhance their anti-cancer activity and to mitigate side-effects were discussed.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Metal complexes synthesis and properties · Nanoparticle-Based Drug Delivery · Ferrocene Chemistry and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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