Targeting of fluorescent palygorskite polyethyleneimine nanocomposite to cancer cells
Source abstract
Abstract
Abstract Palygorskite (Pal), a natural clay mineral, grafted by functional macromolecule polyethyleneimine (PEI) via the coupling grafting method, has further been modified by introducing both fluorescein isothiocyanate (FI) and folic acid (FA), with the aim of specifically targeting and detecting cancer cells. The formed Pal-PEI–FI–FA nanocomposite was nontoxic up to a concentration of 300 μg·mL − 1 , and further could be specially taken up by HeLa cells via FA receptor-mediated endocytosis as shown by confocal microscopy and inductively coupled plasma optical emission spectroscopy (ICP-OES) data. Therefore, it is concluded that the novel Pal-based nanocomposite has great potential for biomedical sensing, diagnosis, and therapeutics.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Clay minerals and soil interactions · Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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