Rheological mucoadhesion and cytotoxicity of montmorillonite clay mineral/hybrid microparticles biocomposite
Source abstract
Abstract
Abstract A biocomposite based on montmorillonite clay mineral (MMT) and hybrid biopolymer microparticles (MP) carrying atorvastatin (AC), these were designed for oral drug carrier was characterized by scanning and transmission electron microscopy (SEM &TEM), differential scanning calorimetry (DSC) and in vitro biocompatibility by cell viability on fibroblast cells. The rheological synergism relation (by linear oscillatory tests at different pH and frequency) with the mucoadhesive properties revealed interactions between isolated mucin and the MP/MMT biocomposite and those between the mucin and the individual components. Results of these tests showed that the MP/MMT biocomposite provides an improvement in the thermal stability and hence good biocompatibility exhibiting anti-proliferation effects at high concentrations. To our knowledge, no previous reports exist on the determination of the rheological synergism in biocomposites with MMT clay either alone. Moreover, we found a dependence of the rheological synergism on pH and frequency provided by linear viscoelastic data at low frequencies. The MP/MMT biocomposite possesses the highest rheological synergism related to the strongest interaction with mucin at pH 1.6.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Polysaccharides Composition and Applications · Polysaccharides and Plant Cell Walls
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. Applied Clay Science Saponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy10.1016/j.clay.2018.09.021 ↗
2. Montmorillonite–chitosan–chlorhexidine composite films with antibiofilm activity and improved cytotoxicity for wound dressing10.1016/j.jcis.2016.12.058 ↗
3. Toxicological effects of a cationic clay, montmorillonite in vitro and in vivo10.1007/s13273-012-0012-x ↗
4. Mucin structure, aggregation, physiological functions and biomedical applications10.1016/j.cocis.2005.11.001 ↗
5. The flame retardancy and rheological properties of PA6/MCA modified by DOPO-based chain extender10.1039/C6RA28293H ↗
6. Rheology of gastric mucin exhibits a pH-dependent sol-gel transition10.1021/bm0609691 ↗
7. The structure and properties of long-chain branching poly(trimethylene terephthalate)10.1007/s00397-013-0737-z ↗
8. Sugar cross-linked gelatin for controlled release: microspheres and disks10.1016/S0142-9612(98)00034-9 ↗
9. Clay-polymer nanocomposites as a novel drug carrier: synthesis, characterization and controlled release study of Propranolol Hydrochloride
10. Poly(D,L-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs10.1016/j.biomaterials.2005.03.021 ↗
11. Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research10.1016/j.jconrel.2013.09.019 ↗
12. Galimberti · 2013
13. Characterization of hybrid microparticles/Montmorillonite composite with raspberry-like morphology for Atorvastatin controlled release10.1016/j.colsurfb.2018.04.020 ↗
14. Methods to determine the interactions of micro- and nanoparticles with mucus10.1016/j.ejpb.2015.01.005 ↗
15. Limitations of the rheological mucoadhesion method: the effect of the choice of conditions and the rheological synergism parameter10.1016/S0928-0987(03)00037-X ↗
16. Chitosan-intercalated montmorillonite/poly (vinyl alcohol) nano fi bers as a platform to guide neuronlike di ff erentiation of human dental pulp stem cells10.1021/acsami.6b14283 ↗
17. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength
18. Mucus permeating thiomer nanoparticles10.1016/j.ejpb.2015.01.004 ↗
19. Atorvastatin calcium encapsulated eudragit nanoparticles with enhanced oral bioavailability, safety and efficacy profile10.3109/10837450.2015.1108983 ↗
20. A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration10.1016/S0168-3659(97)00138-7 ↗
21. Toxicological evaluation of clay minerals and derived nanocomposites: a review10.1016/j.envres.2014.12.024 ↗
22. Effect of pH on the association behavior in aqueous solutions of pig gastric mucin10.1016/j.carres.2007.10.005 ↗
23. Mucoadhesion: a promising approach in drug delivery system10.1016/j.reactfunctpolym.2016.01.011 ↗
24. Simulated biological fluids with possible application in dissolution testing10.14227/DT180311P15 ↗
25. Thermal transitions of gelatin evaluated using DSC sample pans of various seal integrities10.1007/s10973-013-3166-4 ↗
26. Interaction of porcine gastric mucin with various polycations and its influence on the boundary lubrication properties10.1016/j.polymer.2016.08.030 ↗
27. Preparation and evaluation of mucin-gelatin mucoadhesive microspheres for rectal delivery of ceftriaxone sodium10.1080/03639040701360876 ↗
28. Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems10.1007/s40005-016-0258-8 ↗
29. Gelatin-clay nanocomposites of improved properties10.1016/j.polymer.2007.06.068 ↗
30. In vitro biocompatibility and mucoadhesion of montmorillonite chitosan nanocomposite: a new drug delivery10.1016/j.clay.2011.11.006 ↗
31. Intestinal permeability of oxytetracycline from chitosan-montmorillonite nanocomposites10.1016/j.colsurfb.2013.11.009 ↗
32. Study on crosslinked gelatin-montmorillonite nanoparticles for controlled drug delivery applications10.1007/s10853-015-9287-3 ↗
33. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration10.3390/md15120370 ↗
34. Rheological synergy in aqueous mixtures of pectin and mucin10.1016/j.carbpol.2008.03.021 ↗
35. Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori
36. Evaluation of gastric mucoadhesive properties of aminated gelatin microspheres10.1016/S0168-3659(01)00288-7 ↗
37. Biopolymer chitosan/montmorillonite nanocomposites: preparation and characterization10.1016/j.polymdegradstab.2005.03.001 ↗
38. Biopolymer/montmorillonite nanocomposite: preparation, drug-controlled release property and cytotoxicity
39. Assessment of test methods evaluating mucoadhesive polymers and dosage forms: an overview10.1016/j.ejpb.2013.06.023 ↗
40. Charge and interfacial behavior of short side-chain heavily glycosylated porcine stomach mucin10.1021/bm700721c ↗
41. Biological activity and sorption ability of synthetic montmorillonite modifi ed by silver/lysozyme nanoparticles10.1016/j.clay.2018.07.015 ↗
42. Gelatin/montmorillonite hybrid nanocomposite. I. Preparation and properties10.1002/app.11062 ↗