Peculiarities of the 5-fluorouracil adsorption on porous aluminosilicates with different morphologies
Source abstract
Abstract
Abstract The peculiarities of the adsorption of the anticancer drug, 5-fluorouracil, by aluminosilicate matrices with different morphologies — BEA zeolites, layered silicates with saponite (Mg3Si4O10(OH)2.H2O) and montmorillonite (Na0.2Al1.8Mg0.2Si4O10(OH)2.H2O) structures, and nanotubular halloysites (Al2Si2O5(OH)4.2H2O) were investigated. The influence of the polarity of the solvent used (water, acetone, and ethanol), pH-environment (pH = 5, 8, and 11), morphology (framed, layered, and nanotubular), and chemical composition (Al2O3 content 0–40 wt%) of the initial matrix on the amount of the adsorbed drug was studied. To prevent errors associated with the possibility of the existence of various tautomeric forms of fluorouracil in solutions, the adsorption processes were exclusively analysed using thermal analysis coupled with mass spectrometry. The efficiency of 5-fluorouracil adsorption and the loading conditions are largely determined by the chemical composition of the initial aluminosilicate matrix and its morphology. Zeolite exhibited the highest adsorption capacity for fluorouracil under any saturation conditions, while the halloysite matrix showed the lowest capacity.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Clay minerals and soil interactions · Layered Double Hydroxides Synthesis and Applications · Chemical Synthesis and Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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