High-capacity loading of 5-fluorouracil on the methoxy-modified kaolinite
Source abstract
Abstract
Abstract Kaolinite and methoxy-modified kaolinite were used as carriers for the loading of 5-fluorouracil (5FU) for the first time. The kaolinite products were characterized using X-ray diffraction, transmission electron microscopy, elemental analysis, diffuse reflectance infrared Fourier transform spectroscopy, thermogravimetric analysis, and differential scanning calorimetry. The loading mechanism of 5FU on kaolinite was as follows: the 5FU molecules were initially anchored to the external surface of kaolinite through hydrogen bonding, and the added 5FU then formed hydrogen-bonded aggregates with the anchored 5FU on the external surface of kaolinite. The surface-loaded 5FU was crystallite. The 5FU-loading content in the methoxy-modified kaolinite was 55.4 mass%, which was 147.3% greater than that in unmodified kaolinite. The high-capacity loading of 5FU on methoxy-modified kaolinite resulted from two factors: (i) the interlayer space of the methoxy-modified kaolinite acted as an additional loading site that was available for the intercalation of 5FU; (ii) the loading of 5FU on the external surface of the methoxy-modified kaolinite was high because of the high affinity between 5FU and the methoxy-modified kaolinite. The 5FU-loading content of the interlayer-loaded 5FU and the surface-loaded 5FU in the methoxy-modified kaolinite was 14.6 mass% and 40.8 mass%, respectively. The interlayer-loaded 5FU was in an amorphous state, and of higher thermal stability than the surface-loaded 5FU. Methoxy-modified kaolinite is a promising drug carrier in pharmaceutical industry.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Clay minerals and soil interactions · Layered Double Hydroxides Synthesis and Applications · Crystal Structures and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (45)
Show source-provided references
1. Use of clays as drug delivery systems: possibilities and limitations10.1016/j.clay.2006.06.015 ↗
2. Adsorption and interaction of 5-fluorouracil with montmorillonite and saponite by FT-IR spectroscopy10.1016/j.molstruc.2006.11.061 ↗
3. Analytical profile of 5-fluorouracil
4. Adsorption of salicylic acid on bentonite and kaolin and release experiments10.1016/j.clay.2006.07.008 ↗
5. On the estimation of average crystallite size of zeolites from the Scherrer equation: a critical evaluation of its application to zeolites with one-dimensional pore systems10.1016/j.micromeso.2008.06.010 ↗
6. Clay minerals and their beneficial effects upon human health. A review10.1016/S0169-1317(01)00085-0 ↗
7. Clay and non-clay minerals in the pharmaceutical industry: part I. Excipients and medical applications10.1016/j.clay.2009.07.017 ↗
8. Clay and non-clay minerals in the pharmaceutical and cosmetic industries. Part II. Active ingredients10.1016/j.clay.2009.10.016 ↗
9. Bulk and surface properties of commercial kaolins10.1016/j.clay.2010.02.002 ↗
10. Clay minerals and layered double hydroxides for novel biological applications10.1016/j.clay.2006.07.007 ↗
11. Modulated temperature differential scanning calorimetry: a novel approach to pharmaceutical thermal analysis10.1016/0378-5173(95)04463-9 ↗
12. Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios10.1016/j.micromeso.2012.09.011 ↗
13. The structure of an intercalated ordered kaolinite: a Raman microscopy study10.1180/claymin.1997.032.4.09 ↗
14. Role of water in the intercalation of kaolinite with hydrazine10.1006/jcis.1998.5780 ↗
15. Effect of water on the formamide-intercalation of kaolinite10.1016/S1386-1425(00)00224-9 ↗
16. Kinetic insights into the role of the solvent in the polymorphism of 5-fluorouracil from molecular dynamics simulations10.1021/jp055982e ↗
17. Thermal characterization of surfactant-modified montmorillonites10.1346/CCMN.2005.0530308 ↗
18. Preparation of a kaolinite-ε-caprolactam intercalation compound
19. Direct intercalation of poly(vinylpyrrolidone) into kaolinite by a refined guest displacement method10.1021/cm9804721 ↗
20. Intercalation of alkylamines and water into kaolinite with methanol kaolinite as an intermediate10.1016/S0169-1317(99)00014-9 ↗
21. Modification of the interlayer surface of kaolinite with methoxy groups10.1021/la991453o ↗
22. Detection of four different OH-groups in ground kaolinite with controlled-rate thermal analysis10.1023/A:1019981505712 ↗
23. An acentric arrangement of p-nitroaniline molecules between the layers of kaolinite10.1039/a906206h ↗
24. One-step exfoliation of kaolinites and their transformation into nanoscrolls10.1021/la1047134 ↗
25. Clay mineral organic interactions
26. A study of purified montmorillonite intercalated with 5-fluorouracil as drug carrier10.1016/S0142-9612(01)00325-8 ↗
27. Halloysite clay nanotubes for controlled release of protective agents10.1021/nn800259q ↗
28. Cation exchange capacity of kaolinite10.1346/CCMN.1999.0470207 ↗
29. Baseline studies of the clay minerals society source clays: infrared methods10.1346/CCMN.2001.0490508 ↗
30. Formation of physically stable amorphous phase of ibuprofen by solid state milling with kaolin10.1016/j.ejpb.2007.06.003 ↗
31. Preparation of a kaolinite-nylon 6 intercalation compound10.1246/bcsj.74.1153 ↗
32. Sustained release of 5-fluorouracil from polymeric nanoparticles10.1211/0022357001777658 ↗
33. Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d,l-lactide glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior10.1016/0168-3659(93)90097-O ↗
34. In-vitro release characteristics of tetracycline HCl, khellin and nicotinamide adenine dineculeotide from halloysite; a cylindrical mineral10.1080/02652040010019532 ↗
35. Fourier transform Raman spectrum and ab initio and density functional computations of the vibrational spectrum, molecular geometry, atomic charges and some molecular properties of the anticarcinogenic drug 5-fluorouracil10.1002/1097-4555(200007)31:7<595::AID-JRS582>3.0.CO;2-9 ↗
36. Freezing behavior in porous glasses and MCM-4110.1016/S0927-7757(01)00637-9 ↗
37. Intercalation of nitroanilines into kaolinite and second harmonic generation10.1021/cm010095j ↗
38. Natural halloysite nanotubes as mesoporous carriers for the loading of ibuprofen10.1016/j.micromeso.2013.05.007 ↗
39. Preparation and characterization of an 8.4-Angstrom hydrate of kaolinite10.1346/CCMN.1994.0420414 ↗
40. Chemically modified kaolinite. Grafting of methoxy groups on the interlamellar aluminol surface of kaolinite10.1039/jm9960601679 ↗
41. Synthesis and properties of Mg2Al layered double hydroxides containing 5-fluorouracil10.1016/j.jssc.2004.11.005 ↗
42. Effect of reaction temperature on grafting of γ-aminopropyl triethoxysilane (APTES) onto kaolinite10.1016/j.clay.2012.04.006 ↗
43. Functionalization of halloysite clay nanotubes by grafting with γ-aminopropyltriethoxysilane10.1021/jp805657t ↗
44. Organosilane functionalization of halloysite nanotubes for enhanced loading and controlled release10.1088/0957-4484/23/37/375705 ↗
45. Molecular dynamics simulation of organic–inorganic nanocomposites: layering behavior and interlayer structure of organoclays10.1021/cm0342952 ↗