Halloysite-based hybrid bionanocomposite hydrogels as potential drug delivery systems
Source abstract
Abstract
Abstract In this investigation, the preparation of novel Halloysite-based chitosan/oxidized starch (Hal/CTS/OSR) Hybrid bionanocomposite hydrogels is described. The obtained hybrid hydrogels were characterized by using FT-IR, SEM, XRD, TGA and DTG techniques. In addition, the efficiency of hydrogels as drug delivery systems was studied. The results demonstrated that depending on experimental parameters, such as the ratio of CTS/OSR, and the type of Hal nanotubes (modified or unmodified), the hydrogel properties can be affected and modulated significantly. 74.3%, 71.2% and 69.45% MTZ release were observed for CTS/OSR/mHal 10, CTS/OSR and CTS/OSR/Hal 10 respectively.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Clay minerals and soil interactions · Iron oxide chemistry and applications · Therapeutic Uses of Natural Elements
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (69)
Show source-provided references
1. Hydrogel: preparation, characterization, and applications: a review10.1016/j.jare.2013.07.006 ↗
2. Role of silanized halloysite nanotubes on structural, mechanical properties and fracture toughness of thermoset nanocomposites10.1016/j.matdes.2013.12.017 ↗
3. Preparation and adsorption properties of a novel interpenetrating polymer network (IPN) containing carboxyl groups for basic dye from aqueous media10.1016/j.cej.2011.11.077 ↗
4. Carboxy-methyl cellulose hydrogels used to fill breast implants: 15 years of experience10.1007/s002380100272 ↗
5. Biodegradable multiphase systems based on plasticized starch: a review10.1081/MC-200029326 ↗
6. Starch–chitosan hydrogels prepared by reductive alkylation cross-linking10.1023/B:JMSM.0000032815.86972.5e ↗
7. Surface modification of natural halloysite clay nanotubes with aminosilanes. Application as catalyst supports in the atom transfer radical polymerization of methyl methacrylate10.1016/j.apcata.2011.08.003 ↗
8. Recent advances in clay/polymer nanocomposites10.1002/adma.201101948 ↗
9. Nano-biocomposites: biodegradable polyester/nanoclay systems10.1016/j.progpolymsci.2008.10.002 ↗
10. Multilayer vascular grafts based on collagen-mimetic proteins10.1016/j.actbio.2011.11.015 ↗
11. Alginate gel beads filled with halloysite nanotubes10.1016/j.clay.2012.12.001 ↗
12. Biocompatible poly (N-isopropylacrylamide)-halloysite nanotubes for thermoresponsive curcumin release10.1021/acs.jpcc.5b00991 ↗
13. Application of chitosan, a natural aminopolysaccharide, for dye removal from aqueous solutions by adsorption processes using batch studies: a review of recent literature10.1016/j.progpolymsci.2007.11.001 ↗
14. Microfibrous chitosan–sepiolite nanocomposites10.1021/cm0523642 ↗
15. Thermal stability and flame retardant effects of halloysite nanotubes on poly (propylene)10.1016/j.eurpolymj.2005.12.006 ↗
16. Effect of graphene and fullerene nanofillers on controlling the pore size and physicochemical properties of chitosan nanocomposite mesoporous membranes10.1155/2015/979561 ↗
17. In situ generation of sodium alginate/hydroxyapatite/halloysite nanotubes nanocomposite hydrogel beads as drug-controlled release matrices10.1039/c3tb20971g ↗
18. Development of polyion-complex hydrogels as an alternative approach for the production of bio-based polymers for food packaging applications: a review10.1016/j.tifs.2009.04.003 ↗
19. Microwave-promoted synthesis of smart superporous hydrogel for the development of gastroretentive drug delivery system10.1002/adv.21490 ↗
20. The “dialdehydes” from the periodate oxidation of carbohydrates
21. Modified natural halloysite/potato starch composite films10.1016/j.carbpol.2011.11.057 ↗
22. Removal of direct dyes from aqueous solution by oxidized starch cross-linked chitosan/silica hybrid membrane10.1016/j.ijbiomac.2015.11.005 ↗
23. Synthesis of pH-sensitive poly (N, N-dimethylaminoethyl methacrylate)-grafted halloysite nanotubes for adsorption and controlled release of DPH and DS drugs10.1016/j.polymer.2015.03.067 ↗
24. Composition, molecular structure, and physicochemical properties of tuber and root starches: a review10.1016/S0144-8617(00)00260-5 ↗
25. Effects of halloysite nanotubes on physical properties and cytocompatibility of alginate composite hydrogels10.1016/j.msec.2016.09.001 ↗
26. Application of the cleavage type of oxidation by periodic acid to starch and cellulose110.1021/ja01289a077 ↗
27. Halloysite clay minerals–a review10.1180/0009855054040180 ↗
28. Chitosan-modified nanoclay–poly (AMPS) nanocomposite hydrogels with improved gel strength10.1002/pi.2652 ↗
29. Nanoenhanced hydrogel system with sustained release capabilities10.1002/jbm.a.35376 ↗
30. Natural and synthetic biomaterials for controlled drug delivery10.1007/s12272-013-0280-6 ↗
31. Development of silane grafted halloysite nanotube reinforced polylactide nanocomposites for the enhancement of mechanical, thermal and dynamic-mechanical properties10.1016/j.clay.2016.10.046 ↗
32. Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture10.1002/jat.2858 ↗
33. Hydrogels for tissue engineering10.1021/cr000108x ↗
34. In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction10.1016/j.carbpol.2014.03.058 ↗
35. Novel starch/chitosan blending membrane: antibacterial, permeable and mechanical properties10.1016/j.carbpol.2009.03.021 ↗
36. Physically crosslinked composite hydrogels of PVA with natural macromolecules: structure, mechanical properties, and endothelial cell compatibility10.1002/jbm.b.31310 ↗
37. Chitosan/halloysite nanotubes bionanocomposites: structure, mechanical properties and biocompatibility10.1016/j.ijbiomac.2012.06.022 ↗
38. The improvement of hemostatic and wound healing property of chitosan by halloysite nanotubes10.1039/C4RA02189D ↗
39. Functional polymer–clay nanotube composites with sustained release of chemical agents10.1016/j.progpolymsci.2013.05.009 ↗
40. Halloysite clay nanotubes for controlled release of protective agents10.1021/nn800259q ↗
41. Multicavity halloysite–amphiphilic cyclodextrin hybrids for co-delivery of natural drugs into thyroid cancer cells10.1039/C5TB00564G ↗
42. Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications10.1016/j.colsurfb.2016.01.025 ↗
43. Recent progress in dialdehyde starch technology10.1002/star.19660180702 ↗
44. Fe3O4 MNPs and gum xanthan based hydrogels nanocomposites for the efficient capture of malachite green from aqueous solution10.1016/j.cej.2014.04.098 ↗
45. Clay nanotube–biopolymer composite scaffolds for tissue engineering
46. Adsorption of dyes in aqueous solutions by chitosan–halloysite nanotubes composite hydrogel beads10.1016/j.micromeso.2014.09.003 ↗
47. Hydrogels in pharmaceutical formulations10.1016/S0939-6411(00)00090-4 ↗
48. Preparation and properties of natural nanocomposites based on natural rubber and naturally occurring halloysite nanotubes10.1016/j.matdes.2009.11.009 ↗
49. Hydrogel nanocomposites: a review of applications as remote controlled biomaterials10.1039/b925218p ↗
50. Cross-linking chitosan nanofibers10.1021/bm060804s ↗
51. Kappa-carrageenan/halloysite nanocomposite hydrogels as potential drug delivery systems10.1016/j.jtice.2016.07.027 ↗
52. Development of regenerated cellulose/halloysite nanotube bionanocomposite films with ionic liquid10.1016/j.ijbiomac.2013.03.066 ↗
53. Loading and in vitro release of ibuprofen in tubular halloysite10.1016/j.clay.2014.01.018 ↗
54. Dialdehyde starch-crosslinked chitosan films and their antimicrobial effects10.1002/polb.10405 ↗
55. Recent trends in hydrogels based on psyllium polysaccharide: a review10.1016/j.jclepro.2014.06.066 ↗
56. Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review10.1021/bm200083n ↗
57. Polysaccharide-based hydrogels: preparation, characterization, and drug interaction behaviour10.1021/bm7011983 ↗
58. Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release10.1016/j.ijbiomac.2010.01.009 ↗
59. Spray-dried magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin microspheres for sustained release of ofloxacin10.1039/c3ra43874k ↗
60. Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin10.1016/j.carbpol.2013.10.071 ↗
61. Clay nanotube/poly (methyl methacrylate) bone cement composites with sustained antibiotic release10.1002/mame.201100309 ↗
62. Chitosan cross-linking with a water-soluble, blocked diisocyanate. 1. Solid state10.1021/bm025625z ↗
63. Facile synthesis of chitosan/ZnO bio-nanocomposite hydrogel beads as drug delivery systems10.1016/j.ijbiomac.2015.09.064 ↗
64. Artificial nacre-like bionanocomposite films from the self-assembly of chitosan–montmorillonite hybrid building blocks10.1002/anie.201004748 ↗
65. Properties and applications of halloysite nanotubes: recent research advances and future prospects10.1016/j.clay.2015.05.001 ↗
66. Modified corn starches with improved comprehensive properties for preparing thermoplastics10.1002/star.200600598 ↗
67. Applications and interfaces of halloysite nanocomposites10.1016/j.clay.2015.06.034 ↗
68. Enhanced adsorption of ammonium using hydrogel composites based on chitosan and halloysite10.1080/10601320903394421 ↗
69. The integrated utilization of typical clays in removal of organic dyes and polymer nanocomposites10.1016/j.jclepro.2014.06.038 ↗