Ancient materials for new applications: The combination of montmorillonite with polysaccharides for biomedical uses
Source abstract
Abstract
Montmorillonite is a clay mineral that is historically associated with healthcare and has been used since ancient times to combat infections and diseases. In recent years, clay minerals such as montmorillonite have been applied to combine with polysaccharides to produce advanced biomaterials. This review reports on recent progress and contributions in research on bionanocomposites based on montmorillonite and polysaccharides for biomedical applications. The emphasis was placed on aspects related to controlled drug delivery systems, wound dressings, antimicrobial activity, and bone tissue engineering. Furthermore, the physical and chemical characteristics of bionanocomposites were described on a molecular scale and their suitability for specific biomedical applications. Therefore, the present review provides valuable perspectives on how montmorillonite-polysaccharide bionanocomposites can address current challenges in biomedicine, guiding future research toward more effective and versatile therapeutic materials, especially for the biomaterials based on chitosan and cellulose.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Hydrogels: synthesis, properties, applications · Clay minerals and soil interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Chitosan/Ag-Bentonite Nanocomposites: Preparation, Characterization, Swelling and Biological Properties10.1007/s10904-019-01219-8 ↗
2. Enhancement of basic properties of polysaccharide-based composites with organic and inorganic fillers: a review10.1002/app.47251 ↗
3. Synthesis of exfoliate bentonite/cellulose nanocomposite as a delivery system for Oxaliplatin drug with enhanced loading and release properties; cytotoxicity and pharmacokinetic studies10.1016/j.cplett.2020.137818 ↗
4. Utilization of Cellulose to its Full potential: a Review on Cellulose Dissolution, Regeneration, and applications10.3390/polym13244344 ↗
5. Use of clays as drug delivery systems: Possibilities and limitations10.1016/j.clay.2006.06.015 ↗
6. Ultra pH-sensitive nanocarrier based on Fe2O3/chitosan/montmorillonite for quercetin delivery10.1016/j.ijbiomac.2021.09.023 ↗
7. Effect of incorporation of montmorillonite on Xylan/Chitosan conjugate scaffold10.1016/j.colsurfb.2019.04.032 ↗
8. Chitosan–PVA–PVP/nano-clay composite: a promising tool for controlled drug delivery10.1039/D4RA02959C ↗
9. Controlled release of paroxetine from chitosan/montmorillonite composite films
10. Preparation and applications of chitosan and cellulose composite materials10.1016/j.jenvman.2021.113850 ↗
11. Montmorillonite as an agent for drug photostability10.1039/c2jm34120d ↗
12. Promethazine–montmorillonite inclusion complex to enhance drug photostability10.1021/la5033898 ↗
13. Montmorillonite–chitosan–chlorhexidine composite films with antibiofilm activity and improved cytotoxicity for wound dressing10.1016/j.jcis.2016.12.058 ↗
14. Antibacterial activity of chitosan-based nanohybrid membranes against drug-resistant bacterial isolates from burn wound infections10.1007/s00203-022-02918-6 ↗
15. Smart biomaterials—a proposed definition and overview of the field
16. Design of biopolymeric architecture with thiolated chitosan–poly (lactic acid) blend/methionine modified clay for the controlled release of amoxicillin10.1080/03602559.2014.909469 ↗
17. Preparation and characterization of thiolated chitosan immobilized-amino acid intercalated montmorillonite for the controlled release of timolol maleate, a β-adrenergic blocking agent10.1080/00914037.2014.886240 ↗
18. Synthesis and characterization of montmorillonite/N-(carboxyacyl) chitosan coated magnetic particle nanocomposites for controlled delivery of paracetamol10.1016/j.clay.2013.11.039 ↗
19. Chitin and chitosan in selected biomedical applications10.1016/j.progpolymsci.2014.02.008 ↗
20. Classification of Biomaterial Functionality10.1016/B978-0-12-815732-9.00027-9 ↗
21. Trends in the use of montmorillonite as a delivery system for active substances10.1007/s11051-023-05796-1 ↗
22. Kaolinite in pharmaceutics and biomedicine10.1016/j.ijpharm.2017.09.056 ↗
23. Toxicological effects of a cationic clay, montmorillonite in vitro and in vivo10.1007/s13273-012-0012-x ↗
24. Influence of purification method of Na-montmorillonite on textural properties of clay mineral composites with TiO2 nanoparticles10.1016/j.clay.2017.01.032 ↗
25. Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment10.3389/fbioe.2022.1016001 ↗
26. Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite10.1002/pat.3406 ↗
27. Montmorillonite stabilized chitosan-co-mucin hydrogel for tissue engineering applications10.1039/D1RA04803A ↗
28. Synergism between α-amino acid-derived polyamidoamines and sodium montmorillonite for enhancing the flame retardancy of cotton fabrics10.1016/j.polymdegradstab.2024.110764 ↗
29. Raw and purified clay minerals for drug delivery applications10.1021/acsomega.2c04510 ↗
30. Development of novel montmorillonite-based sustained release system for oral bromopride delivery10.1016/j.ejps.2022.106222 ↗
31. A review of natural polysaccharides: sources, characteristics, properties, food, and pharmaceutical applications10.3390/ijms25021322 ↗
32. Facile synthesis and characterization of tailor-made pectin-gellan gum-bionanofiller composites as intragastric drug delivery shuttles10.1016/j.ijbiomac.2018.06.085 ↗
33. Ziprasidone-loaded arabic gum modified montmorillonite-tailor-made pectin based gastroretentive composites10.1016/j.ijbiomac.2019.01.171 ↗
34. General introduction: Clays, clay minerals, and clay science
35. Bergaya, F., Lagaly, G., 2013b. Purification of Natural Clays, in: Bergaya, F., Lagaly, G. (Eds.), Handbook of Clay Science. Elsevier, Amsterdam, pp. 213–221, https://doi.org/10.1016/B978-0-08-098258-8.00008-0.10.1016/B978-0-08-098258-8.00008-0 ↗
36. Solid Oral Controlled-Release Formulations
37. Organically modified clay supported chitosan/hydroxyapatite-zinc oxide nanocomposites with enhanced mechanical and biological properties for the application in bone tissue engineering10.1016/j.ijbiomac.2017.07.168 ↗
38. Chitosan coated layered clay montmorillonite nanocomposites modulate oral delivery of paclitaxel in colonic cancer10.1179/1753555714Y.0000000174 ↗
39. Structure and Mineralogy of Clay Minerals
40. Multifunctional dopamine modification of green antibacterial hemostatic sponge10.1016/j.msec.2021.112227 ↗
41. Chitosan/montmorillonite nanocomposite film as anticancer drug carrier: a promising biomaterial to treat skin cancers10.1016/j.ceramint.2024.02.337 ↗
42. Clays and health: An introduction10.1016/j.clay.2006.09.001 ↗
43. Clay and non-clay minerals in the pharmaceutical industry: part I. Excipients and medical applications10.1016/j.clay.2009.07.017 ↗
44. Clay and non-clay minerals in the pharmaceutical and cosmetic industries Part II10.1016/j.clay.2009.10.016 ↗
45. Clays, drugs, and Human Health
46. The intercalation of zinc(II)-1,10-phenanthroline complexes in montmorillonite: An experimental and theoretical approach10.1016/j.clay.2024.107366 ↗
47. Thiabendazole/bentonites hybrids as controlled release systems10.1016/j.colsurfb.2018.12.030 ↗
48. The anti-inflammatory activity of bentonites10.1016/j.clay.2015.08.039 ↗
49. Modified montmorillonite nanosheets as a nanocarrier with smart pH-responsive control on the antimicrobial activity of tetracycline upon release10.1016/j.clay.2019.105135 ↗
50. Nanopolysaccharides (polysaccharide-based nanoparticles): perspectives and applications
51. A mechanistic insight into the shrinkage and swelling of Ca-montmorillonite upon adsorption of chain-like ranitidine in an aqueous system10.1016/j.jcis.2022.11.104 ↗
52. Tramadol hydrochloride/montmorillonite composite: Preparation and controlled drug release10.1016/j.clay.2010.04.011 ↗
53. Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging10.1016/j.carbpol.2017.05.088 ↗
54. Transformation of tetracyclines induced by Fe(III)-bearing smectite clays under anoxic dark conditions10.1016/j.watres.2019.114997 ↗
55. Sustainable cellulose and its derivatives for promising biomedical applications10.1016/j.pmatsci.2023.101152 ↗
56. Understanding the drug release mechanism from a montmorillonite matrix and its binary mixture with a hydrophilic polymer using a compartmental modelling approach10.1088/1757-899X/333/1/012065 ↗
57. An Introduction to Montmorillonite Purification
58. Cosmetic packaging to save the environment: future perspectives10.3390/cosmetics6020026 ↗
59. Innovative eco-friendly hydrogel film for berberine delivery in skin applications10.3390/molecules26164901 ↗
60. Polysaccharide hydroxyapatite (nano)composites and their biomedical applications: an overview of recent years10.1021/acsomega.4c02170 ↗
61. Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering10.1038/s41467-019-11511-3 ↗
62. Clays as vehicles for drug photostability
63. What happens when chitosan meets bentonite under microwave-assisted conditions? Clay-based hybrid nanocomposites for dye adsorption10.1016/j.colsurfa.2020.125584 ↗
64. Current synthesis and characterization techniques for clay-based polymer nano-composites and its biomedical applications: a review10.1016/j.envres.2022.113534 ↗
65. Polysaccharides of Biomedical Importance from Genetically Modified Microorganisms
66. An acid-free water-born quaternized chitosan/montmorillonite loaded into an innovative ultra-fine bead-free water-born nanocomposite nanofibrous scaffold; in vitro and in vivo approaches10.1088/1748-605X/aa7608 ↗
67. Natural Biopolymers for Biomedical applications10.1016/B978-0-12-801238-3.11026-8 ↗
68. An ancient solution to a modern problem10.1111/mmi.14481 ↗
69. Intelligent and smart biomaterials for sustainable 3D printing applications
70. Recent advances on nanohybrid systems constituting clay–chitosan with organic molecules – a review10.1016/j.clay.2022.106548 ↗
71. When RNA meets montmorillonite: Influence of the pH and divalent cations10.1016/j.clay.2021.106234 ↗
72. Montmorillonite with essential oils as antimicrobial agents, packaging, repellents, and insecticides: an overview10.1016/j.colsurfb.2021.112186 ↗
73. Monitoring the antimicrobial activity of bentonite-chlorhexidine hybrid
74. Synergic antimicrobial properties of Carvacrol essential oil and montmorillonite in biodegradable starch films10.1016/j.ijbiomac.2020.07.226 ↗
75. Enhancing the mechanical properties and providing bioactive potential for graphene oxide/montmorillonite hybrid dental resin composites
76. Strontium-modified chitosan/montmorillonite composites as bone tissue engineering scaffold10.1016/j.msec.2018.03.021 ↗
77. Montmorillonite-lipid hybrid carriers for ionizable and neutral poorly water-soluble drugs: Formulation, characterization and in vitro lipolysis studies10.1016/j.ijpharm.2017.04.063 ↗
78. Kaolinite-polymer nanocomposites
79. Preparation of Ibuprofen-loaded geonanohybrids using a facile grinding process10.36468/pharmaceutical-sciences.625 ↗
80. Bioadhesive patches based on carboxymethyl cellulose/polyvinylpyrrolidone/bentonite composites and Soluplus® for skin administration of poorly soluble molecules10.1016/j.clay.2021.106377 ↗
81. Eco-efficient treatment of hazardous bauxite liquid-residue using acid-activated clays
82. Recent advances in cellulose, chitosan, and alginate based biopolymeric composites for adsorption of heavy metals from wastewater10.1016/j.jtice.2023.105095 ↗
83. Development and physicochemical properties of chitosan/starch/bentonite based ternary nanocomposite film for wound healing
84. Biomaterials for tissue engineering applications and current updates in the field: a comprehensive review10.1208/s12249-022-02419-1 ↗
85. Nanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineering10.1016/j.ijpharm.2022.121895 ↗
86. Norfloxacin-loaded electrospun scaffolds: Montmorillonite nanocomposite vs
87. Recent trends on biomaterials for tissue regeneration applications: review10.1007/s10853-022-08102-x ↗
88. Facile preparation and characterization of pH sensitive Mt/CMC nanocomposite hydrogel beads for propranolol controlled release10.1016/j.ijbiomac.2018.01.061 ↗
89. Montmorillonite-famotidine/chitosan bio-nanocomposite hydrogels as a mucoadhesive/gastroretentive drug delivery system10.5812/ijpr-127035 ↗
90. A study on sustained release formulations for oral delivery of 5-fluorouracil based on alginate–chitosan/montmorillonite nanocomposite systems10.1016/j.clay.2014.09.004 ↗
91. The effect of montmorillonite in graphene oxide/chitosan nanocomposite on controlled release of gemcitabine10.1007/s00289-021-03774-y ↗
92. A pH-sensitive magnetic hydrogel nanocomposite based on alginate for controlled release of methotrexate
93. Montmorillonite: An advanced material with diverse pharmaceutical and medicinal applications10.1016/j.pharma.2024.11.001 ↗
94. Structural investigation of polysaccharides and nanocompositions based on them10.1134/S1068162011070053 ↗
95. Magnetic-responsive polysaccharide hydrogels as smart biomaterials: Synthesis, properties, and biomedical applications10.1016/j.carbpol.2022.119665 ↗
96. Monitoring diclofenac adsorption by organophilic alkylpyridinium bentonites10.1016/j.chemosphere.2019.125109 ↗
97. The versatility of montmorillonite in water remediation using adsorption: current studies and challenges in drug removal10.1016/j.jece.2022.107341 ↗
98. Low-dielectric thermosetting resins derived from polysaccharide unsaturated esters10.1016/j.polymdegradstab.2024.111011 ↗
99. Biomedical applications of bionanocomposites10.1016/B978-0-323-91764-3.00015-2 ↗
100. Extraction and characterization of celluloses from various plant byproducts10.1016/j.ijbiomac.2020.04.264 ↗