Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride
Source abstract
Abstract
The present study focused on the intercalation of lidocaine hydrochloride (LC), an antiarrhythmic local anesthetic drug into montmorillonite (MMT) as a controlled release drug carrier. The intercalation compound (MMT-LC) was characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, particle size, electrokinetic mobility and thermal analysis. MMT-LC was compounded with alginate (AL) to form a hydrogel composite and to study its release response in gastric environments. The in vitro release experiments revealed that LC was released from MMT/AL in a controlled way which was pH dependent.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Clay minerals and soil interactions · Polymer Nanocomposites and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (19)
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