Carboxymethyl cellulose capsulated layered double hydroxides/drug nanohybrids for Cephalexin oral delivery
Source abstract
Abstract
Abstract In this paper, pH sensitive carboxymethyl cellulose (CMC) beads were proposed as a protective capsule for layered double hydroxides-drug (LDH-Drug) nanohybrids in gastrointestinal tract conditions. Cephalexin (CPX), as a model drug, was intercalated between LDH layers through co-precipitation method. The resulting nanohybrid (LDH-CPX) was used to prepare nanocomposite hydrogel beads by association with carboxymethyl cellulose. The synthesized products were characterized using FTIR, XRD and SEM analysis. In vitro drug delivery tests were carried out in conditions simulating the gastrointestinal tract to prove the effectiveness of these novel nanocomposite beads as a controlled drug delivery system. The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for CMC encapsulated LDH-CPX nanohybrids.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Layered Double Hydroxides Synthesis and Applications · Nanomaterials for catalytic reactions · Magnesium Oxide Properties and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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