Study on ibuprofen/montmorillonite intercalation composites as drug release system
Source abstract
Abstract
The present paper focused on the intercalation of ibuprofen (IBU) into montmorillonite as a sustained release drug carrier. The intercalation compounds were characterized by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), and thermogravimetric analysis (TGA). The basal spacing of montmorillonite increased from 1.25 nm to 1.57 nm. The decomposition temperature of intercalated IBU was increased to 471 °C. The in vitro release experiments revealed that IBU was released from MMT steadily and pH dependent.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Layered Double Hydroxides Synthesis and Applications · Clay minerals and soil interactions · Polymer Nanocomposites and Properties
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References (8)
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1. Development of sustained-release ibuprofen microspheres using solvent evaporation technique10.1002/(SICI)1521-4184(199911)332:11<405::AID-ARDP405>3.0.CO;2-0 ↗
2. Development and evaluation of a multiple-unit oral sustained release dosage form for S(+)-ibuprofen: preparation and release kinetics10.1016/S0378-5173(99)00320-8 ↗
3. Gennaro · 1990 · vol. XVIII
4. Hutchison · 1973
5. Ibuprofen release kinetics from controlled-release tablets granulated with aqueous polymeric dispersion of ethylcellulose II: Influence of several parameters and coexcipients10.1016/S0168-3659(98)00080-7 ↗
6. Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents-I. Intercalation and in vitro release of ibuprofen10.1016/S0378-5173(01)00629-9 ↗
7. Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs10.1056/NEJM199906173402407 ↗
8. Interaction of functional groups of gelatin and montmorillonite in nanocomposite10.1002/app.23435 ↗