Magnetic casein/CaCO3/Fe3O4 microspheres stimulate osteogenic differentiation
Source abstract
Abstract
The quality of life is significantly impacted by bone defects, which calls for the creation of optimum restorative materials with particular qualities. Current repair materials, such as metal alloys, polymer scaffolds, and bone cement, have a number of drawbacks, such as poor fracture toughness, non-degradability, and insufficient osteogenic ability. To address these challenges, we designed a novel magnetic casein/CaCO3/Fe3O4 microspheres (CCFM), combining biodegradability, osteoinductivity, osteoconductivity, and osteogenesis properties together. In vitro studies confirmed the outstanding biocompatibility and osteogenic differentiation effects on MC3T3-E1 cells of CCFM, highlighting their potential as a promising bone regeneration platform for clinical applications. As a novel bone repair material with superparamagnetic properties, CCFM not only possess good osteoinductivity, osteoconductivity, and osteogenesis properties but also can remain in the lesion location for a long time under an external magnetic field, representing a significant advancement in the field of bone tissue engineering and offering new possibilities for effective bone defect remediation and patient care.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Bone and Dental Protein Studies · Proteins in Food Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University 1 , Guangzhou 510055, People’s Republic of China
Department of Orthodontics, School of Dental Medicine, University of Pennsylvania 2 , 240 South 40th Street, Philadelphia, Pennsylvania 19140, USA
Funding
National Nature Science Foundation of China
References (47)
Show source-provided references
1. Advances in the application of bone transport techniques in the treatment of bone nonunion and bone defects10.1111/os.13936 ↗
2. Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering10.1186/s13287-023-03265-z ↗
3. Advances of stimulus-responsive hydrogels for bone defects repair in tissue engineering10.3390/gels8060389 ↗
4. Poly(lactic-co-glycolic acid)-based composite bone-substitute materials10.1016/j.bioactmat.2020.08.016 ↗
5. Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair10.1093/rb/rbad030 ↗
6. Research progress on emerging polysaccharide materials applied in tissue engineering10.3390/polym14163268 ↗
7. Progress and applications of polyphosphate in bone and cartilage regeneration10.1155/2019/5141204 ↗
8. GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: Therapeutic strategies and recent advances10.1186/s40824-023-00422-6 ↗
9. Current advances and applications of tantalum element in infected bone defects10.1021/acsbiomaterials.2c00884 ↗
10. Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies10.1016/j.bioactmat.2021.03.035 ↗
11. Bone-regeneration therapy using biodegradable scaffolds: Calcium phosphate bioceramics and biodegradable polymers10.3390/bioengineering11020180 ↗
12. Calcium phosphate-based biomaterials for bone repair10.3390/jfb13040187 ↗
13. Natural and synthetic polymers for bone scaffolds optimization10.3390/polym12040905 ↗
14. Polymer fiber scaffolds for bone and cartilage tissue engineering10.1002/adfm.201903279 ↗
15. In situ rapid-formation sprayable hydrogels for challenging tissue injury management10.1002/adma.202400310 ↗
16. Casein-based hydrogels: A mini-review10.1016/j.foodchem.2019.126063 ↗
17. Invited review: Caseins and the casein micelle: Their biological functions, structures, and behavior in foods10.3168/jds.2013-6831 ↗
18. Casein micelles and their internal structure10.1016/j.cis.2012.01.002 ↗
19. On the structural models of bovine casein micelles-review and possible improvements10.1039/c0sm00806k ↗
20. Fabrication of uniform casein/CaCO3 vaterite microspheres and investigation of its formation mechanism10.1021/acs.cgd.7b00306 ↗
21. Calcium carbonate nanoparticles as cancer drug delivery system10.1517/17425247.2015.1049530 ↗
22. Cockle shell-derived calcium carbonate (aragonite) nanoparticles: A dynamite to nanomedicine10.3390/app9142897 ↗
23. A strategy of precipitated calcium carbonate (CaCO3) fillers for enhancing the mechanical properties of polypropylene polymers10.1007/s11814-015-0057-3 ↗
24. Bio-inspired synthesis of hybrid tube-like structures based on CaCO3 and type I-collagen10.1039/c6ra18984a ↗
25. Precipitation, characterization, and kinetic modeling of calcium carbonate prepared using sodium myristate10.1080/00986445.2019.1668784 ↗
26. Effect of a lipopeptide biosurfactant on the precipitation of calcium carbonate10.1016/j.colsurfb.2018.11.009 ↗
27. Electrokinetic potential, thermal and microscopic investigation of surfactant-polymer templates on precipitated calcium carbonate morphology with dynamic simulation10.1002/slct.201702351 ↗
28. Metal/metal oxide-carbohydrate polymers framework for industrial and biological applications: Current advancements and future directions10.1016/j.carbpol.2023.120936 ↗
29. Recent advances of magnetic gold hybrids and nanocomposites, and their potential biological applications10.3390/magnetochemistry8040038 ↗
30. Magnetite nanoparticles: Synthesis and applications in optics and nanophotonics10.3390/ma15072601 ↗
31. Recent progress in synthesis and functionalization of multimodal fluorescent-magnetic nanoparticles for biological applications10.3390/app8020172 ↗
32. Recent trends in preparation and biomedical applications of iron oxide nanoparticles10.1186/s12951-023-02235-0 ↗
33. A novel and rapid approach for the synthesis of biocompatible and highly stable Fe3O4/SiO2 and Fe3O4/C core/shell nanocubes and nanorods10.1039/c6nj03697j ↗
34. The effect of shape on cellular uptake of gold nanoparticles in the forms of stars, rods, and triangles10.1038/s41598-017-04229-z ↗
35. The promoting effect on pre-osteoblast growth under electrical and magnetic double stimulation based on PEDOT/Fe3O4/PLGA magnetic-conductive bi-functional scaffolds10.1039/c8tb00985f ↗
36. Design of Fe3O4@SiO2@mSiO2-organosilane carbon dots nanoparticles: Synthesis and fluorescence red-shift properties with concentration dependence10.1016/j.matdes.2018.04.051 ↗
37. Recyclable magnetic fluorescent Fe3O4@SiO2 core–shell nanoparticles decorated with carbon dots for fluoride ion removal10.1021/acsanm.1c00238 ↗
38. Core–satellite nanocomposite catalysts protected by a porous silica shell: Controllable reactivity, high stability, and magnetic recyclability10.1002/anie.200803968 ↗
39. Enhancing proliferation and osteogenic differentiation of HMSCs on casein/chitosan multilayer films10.1016/j.colsurfb.2016.01.033 ↗
40. Calcium carbonate crystallization in the presence of casein10.1021/cg3005213 ↗
41. Contribution of aggregation to the growth mechanism of seeded calcium carbonate precipitation in the presence of polyacrylic acid10.1021/jp103787p ↗
42. Development of CaCO3 microsphere-based composite hydrogel for dual delivery of growth factor and Ca to enhance bone regeneration10.1039/c9bm00463g ↗
43. Study on the thermal behavior of casein under nitrogen and air atmosphere by means of the TG-FTIR technique10.1016/j.tca.2012.07.031 ↗
44. How useful is SBF in predicting in vivo bone bioactivity?10.1016/j.biomaterials.2006.01.017 ↗
45. Fe3O4@SiO2–NH2 core–shell nanocomposite as an efficient and green catalyst for the multi-component synthesis of highly substituted chromeno[2,3-b]pyridines in aqueous ethanol media10.1080/17518253.2015.1107139 ↗
46. Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix10.1002/jcp.1041430304 ↗
47. Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model10.1016/j.jiec.2017.03.057 ↗