Light-induced antimicrobial activities of porphyrin derivatives as photosensitizers
Source abstract
Abstract
Antimicrobial photodynamic therapy has considerable promise in the fight against bacterial infections. The superior photophysical characteristics of porphyrins have made them effective photosensitizers in the field of phototherapy. Herein, the light-induced antimicrobial effects of three porphyrins with different substituents have been compared. 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (THPP) shows superior photosensitizing activity and antimicrobial ability under irradiation with green light. THPP can also inhibit and destroy mature Staphylococcus aureus biofilms under irradiation. This work provides a reference for the rational design of photosensitizers for application in antimicrobial photodynamic therapy.
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Research context
OpenAlex topics: Photodynamic Therapy Research Studies · Nanoplatforms for cancer theranostics · Porphyrin and Phthalocyanine Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Laboratory Medicine, Beihua University 1 , 3999 Binjiang East Road, Jilin, Jilin 132013, People’s Republic of China
Department of Laboratory Medicine Center, China-Japan Union Hospital, Jilin University 2 , 126 Xiantai Street, Changchun, Jilin 130033, People’s Republic of China
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences 3 , Changchun, Jilin 130022, People’s Republic of China
Funding
Jilin Province Science and Technology Development Plan Project · National Natural Science Foundation of China
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