Polysaccharide-based aerogel dressing integrated with MOF-loaded quercetin with multifunctional effects for promoting infected wound healing
Source abstract
Abstract
Infectious wounds disrupt the progression through the stages of wound healing, resulting in the development of chronic wounds. However, the current therapeutic approach is limited and requires repeated administrations. A major challenge in infectious wounds is to achieve sustained drug release. Herein, quercetin with anti-inflammatory and antibacterial properties was encapsulated within amino-functionalized UIO-66 metal-organic framework (MOF) to form MOF@Que NPs. MOF@Que NPs were then loaded into an aerogel constructed with agarose, aldehyde hyaluronic acid, and carboxymethyl chitosan to obtain ACA-MOF@Que for targeting different phases of wound healing. The polysaccharide-based aerogel was formed by the entanglement of polymer chains and the Schiff base reaction, which exhibited uniform pore structures and low-swelling properties. Furthermore, the ACA-MOF@Que aerogel also exhibited antioxidant, anti-inflammatory, and antibacterial properties. In vivo and in vitro experiments confirmed that the ACA-MOF@Que aerogel could promote hemostasis in the initial stage of wound healing, reduce cellular inflammatory infiltration, and inhibit the inflammatory response by regulating macrophage polarization during the inflammatory stage of wound healing. Finally, the ACA-MOF@Que aerogel could promote angiogenesis and increase collagen deposition in the later stage of wound healing. Compared with the untreated group, the wounds of rats treated with the ACA-MOF@Que aerogel had almost completely healed on the 14th day. Therefore, the ACA-MOF@Que aerogel plays multiple roles at various stages of wound healing, providing a promising therapeutic approach for the clinical application of chronic wounds.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Aerogels and thermal insulation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Clinical Translation and Regenerative Medicine, The Second Affiliated Hospital of Shenzhen University 1 , Shenzhen,
Bao’an District Clinical Medical Research Center for Trauma, The Second Affiliated Hospital of Shenzhen University 2 , Shenzhen,
Republican Scientific and Practical Center of Transfusiology and Medical Biotechnology, The Ministry of Health of the Republic of Belarus 3 , Minsk,
Minsk Regional Clinical Hospital 4 , Minsk,
Guangdong Huayi Biomedical Science and Technology Center 5 , Guangzhou,
Engineering Technology Research Center for Sports Assistive Devices of Guangdong, Guangzhou Sport University 6 , Guangzhou,
Ward for Trauma and Burn Care, The Second Affiliated Hospital of Shenzhen University 7 , Shenzhen,
Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital 8 , Beijing,
Department of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University 9 , Shenzhen,
Funding
Sanming Project of Medicine in Shenzhen · Shenzhen Science and Technology Innovation Council of China · Shenzhen Bao’an District Medical Association · Science and Technology Innovation Bureau of Bao’an District · Province General University Youth Innovative Talent · Guangdong Province university characteristicinnovation project · Natural Science Foundation of Guangdong Province · National Natural Science Foundation of China · 2024 High-quality Development Research Project of Shenzhen Bao’an Public Hospital
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