Functional gold nanoparticles in diagnosis and treatment of cancer: A systematic review
Source abstract
Abstract
Early diagnosis and prompt treatment of cancer are critical to reducing mortality rates and enhancing patient quality of life. Nanotechnology-driven cancer diagnosis and treatment are emerging approaches widely adopted in early cancer diagnosis and treatment, effectively addressing the high costs, potential radiation risks, and sensitivity limitations of traditional methods. Among the diverse range of nanomaterials, gold nanoparticles (Au NPs) have demonstrated remarkable potential for cancer diagnosis and treatment owing to their exceptional physicochemical stability and distinctive localized surface plasmon resonance effect. Moreover, their small size enables Au NPs to target malignant tumor tissues passively through the enhanced permeation and retention effect. This review begins with a concise overview of the optical properties of Au NPs, followed by an examination of the detection mechanism of Au NP-based biosensors for cancer markers and a systematic summary of the related early diagnosis studies. The latest advances in Au NPs-based optical therapeutic technology research, including photothermal therapy, photodynamic therapy, and combination therapy in the field of cancer treatment, are highlighted. Finally, this review provides an outlook for further applications of Au NPs in diagnostic and therapeutic integration.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Gold and Silver Nanoparticles Synthesis and Applications · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology, Xinjiang Medical University 1 , Urumqi 830054,
Institute of Medical Engineering Interdisciplinary Research, Xinjiang Medical University 2 , Urumqi 830017,
Orthopaedic Research Center, Sixth Affiliated Hospital of Xinjiang Medical University 3 , Tianshan District, Urumqi 830002,
Shaanxi Collaborative Innovation Center of TCM Technologies and Devices, Shaanxi University of Chinese Medicine 4 , Xixian New Area 712046,
Funding
Natural Science Foundation of Xinjiang Uygur Autonomous Region · Xinjiang Tianchi Doctoral Project · Xinjiang Medical University · State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Disease and Central Asia · Key Scientific Research Program of Shaanxi Provincial Education Department
References (100+)
Show source-provided references
1. Cancer’s deadly signature10.1038/ng0103-10 ↗
2. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries10.3322/caac.21834 ↗
3. Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: A multicentre randomised clinical trial10.1136/thoraxjnl-2021-218337 ↗
4. Liquid biopsies: The future of cancer early detection10.1186/s12967-023-03960-8 ↗
5. Breath analysis of cancer in the present and the future10.1183/16000617.0002-2019 ↗
6. Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults10.1038/s41591-023-02620-0 ↗
7. Advances in cancer research: Current and future diagnostic and therapeutic strategies10.3390/bios14020100 ↗
8. Identification and characterization of tumor and stromal derived liquid biopsy analytes in pancreatic ductal adenocarcinoma10.1186/s13046-024-03262-x ↗
9. Bacteria-based cancer therapy: Looking forward10.1016/j.bbcan.2024.189112 ↗
10. In situ gels for postoperative cancer treatment: Current status and challenges10.1016/j.cej.2025.159621 ↗
11. Drug repurposing for cancer therapy, easier said than done10.1016/j.semcancer.2019.12.012 ↗
12. Advances in radiotherapy and its impact on second primary cancer risk: A multi-center cohort study in prostate cancer patients10.1016/j.radonc.2023.109659 ↗
13. Tailoring electron-rich fluorescent supramolecular organic frameworks for efficient capture and visual monitoring of iodine10.1002/adfm.202413694 ↗
14. Cucurbiturils-mediated noble metal nanoparticles for applications in sensing, SERS, theranostics, and catalysis10.1002/adfm.202007277 ↗
15. Functional inorganic nanoparticles in cancer: Biomarker detection, imaging, and therapy10.1063/5.0231279 ↗
16. Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of gold nanoparticles10.1038/s41598-017-11491-8 ↗
17. Analyte induced AuNPs aggregation enhanced surface plasmon resonance for sensitive detection of paraquat10.1016/j.bios.2018.06.057 ↗
18. Bioorthogonal ‘click and release’ reaction-triggered aggregation of gold nanoparticles combined with released lonidamine for enhanced cancer photothermal therapy10.1002/anie.202318539 ↗
19. The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives10.1016/j.addr.2022.114614 ↗
20. Size matters: Gold nanoparticles in targeted cancer drug delivery10.4155/tde.12.21 ↗
21. Off to the organelles-killing cancer cells with targeted gold nanoparticles10.7150/thno.10657 ↗
22. Interfacing nanomaterials with biology through ligand engineering10.1021/acs.accounts.3c00255 ↗
23. Colorimetric and SERS dual-mode detection of GSH in human serum based on AuNPs@Cu-porphyrin MOF nanozyme10.1016/j.aca.2024.342552 ↗
24. Entrapping gold nanoparticles in membranes for simple-to-use enhanced fluorescence detection of proteins10.1016/j.aca.2022.339443 ↗
25. FRET-based aptamer biosensor for selective and sensitive detection of aflatoxin B1 in peanut and rice10.1016/j.foodchem.2016.10.004 ↗
26. Hybrid nanogel-wrapped anisotropic gold nanoparticles feature enhanced photothermal stability10.1002/smll.202404097 ↗
27. Nanocarrier-mediated photochemotherapy and photoradiotherapy10.1002/adhm.201701211 ↗
28. The effect of phospho-peptide on the stability of gold nanoparticles and drug delivery10.1186/s12951-019-0522-y ↗
29. Photodynamic therapy (PDT) for lung cancers10.1097/01243894-200606000-00018 ↗
30. Metabolic codependencies in the tumor microenvironment and gastric cancer: Difficulties and opportunities10.1016/j.biopha.2023.114601 ↗
31. Nanotechnology for multimodal synergistic cancer therapy10.1021/acs.chemrev.7b00258 ↗
32. ROS signalling in the biology of cancer10.1016/j.semcdb.2017.05.023 ↗
33. ROS regulation in gliomas: Implications for treatment strategies10.3389/fimmu.2023.1259797 ↗
34. Tumor therapy utilizing dual-responsive nanoparticles: A multifaceted approach integrating calcium-overload and PTT/CDT/chemotherapy10.1016/j.jconrel.2024.10.029 ↗
35. Drug delivery with carbon nanotubes for in vivo cancer treatment10.1158/0008-5472.can-08-1468 ↗
36. Materials genome evolution of surface plasmon resonance characteristics of Au nanoparticles decorated ZnO nanorods10.1063/5.0023540 ↗
37. The optical properties of metal nanoparticles: The influence of size, shape, and dielectric environment10.1021/jp026731y ↗
38. Gold nanorods: From synthesis and properties to biological and biomedical applications10.1002/adma.200802789 ↗
39. Localized surface plasmon resonances in self-doped copper chalcogenide binary nanocrystals and their emerging applications10.1016/j.nantod.2020.100892 ↗
40. Two-photon absorption and photoluminescence of colloidal gold nanoparticles and nanoclusters10.1039/c8cs00849c ↗
41. Advances in photothermal nanomaterials for biomedical, environmental and energy applications10.1039/d1nr04197e ↗
42. Single-particle tracking with scattering-based optical microscopy10.1021/acs.analchem.9b02760 ↗
43. Growth of monodisperse gold nanospheres with diameters from 20 nm to 220 nm and their core/satellite nanostructures10.1002/adom.201300359 ↗
44. Successive, seed-mediated growth for the synthesis of single-crystal gold nanospheres with uniform diameters controlled in the range of 5–150 nm10.1002/ppsc.201300256 ↗
45. Plasmonic anisotropic gold nanorods: Preparation and biomedical applications10.1007/s12274-022-4191-z ↗
46. Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals10.1038/ncomms8571 ↗
47. Photosensitive ion channels in layered MXene membranes modified with plasmonic gold nanostars and cellulose nanofibers10.1038/s41467-023-36039-5 ↗
48. Controllable synthesis of Au nanostar with plasmonic hybridization properties and its sensitive molecular recognition applications10.1016/j.optmat.2022.112483 ↗
49. Active plasmonics: Principles, structures, and applications10.1021/acs.chemrev.7b00252 ↗
50. Self-assembly of core-satellite gold nanoparticles for colorimetric detection of copper ions10.1016/j.aca.2013.09.036 ↗
51. Magnetically optimized surface enhanced Raman scattering detection strategy and its sensing applications10.1016/j.ccr.2024.215848 ↗
52. Near-infrared-fluorescent probes for bioapplications based on silica-coated gold nanobipyramids with distance-dependent plasmon-enhanced fluorescence10.1021/acs.analchem.6b03034 ↗
53. Plasmonic sensing of Cu2+ via shell-etching of Au@Ag nanorods10.1016/j.matchemphys.2020.124036 ↗
54. Recent trends and impact of localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS) in modern analysis10.1016/j.jpha.2024.02.013 ↗
55. Plasmon-induced hot-electron generation at nanoparticle/metal-oxide interfaces for photovoltaic and photocatalytic devices10.1038/nphoton.2013.238 ↗
56. Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy10.1021/nn4011686 ↗
57. Biomolecule-tailored assembly and morphology of gold nanoparticles for LSPR applications10.1016/j.nantod.2020.101005 ↗
58. Combination of gold nanoparticles with near-infrared light as an alternative approach for melanoma management10.1016/j.ijpharm.2024.124952 ↗
59. FRET-based analysis on the fate of liposome and cyclodextrin@liposome nanocomposites from ocular surface to the posterior segment of the eye10.1016/j.jconrel.2024.11.079 ↗
60. The Raman effect in crystals10.1038/122477a0 ↗
61. On the critical role of Rayleigh scattering in single-molecule surface-enhanced Raman scattering via a plasmonic nanogap10.1039/c6nr04574j ↗
62. Recent developments and applications of surface enhanced Raman scattering spectroscopy in safety detection of fruits and vegetables10.1016/j.foodchem.2023.137469 ↗
63. Near-infrared light-responsive nanomaterials for cancer theranostics10.1002/wnan.1347 ↗
64. SERS tags for biomedical detection and bioimaging10.7150/thno.66859 ↗
65. Molecular hot spots in surface-enhanced Raman scattering10.1039/d0nr06579j ↗
66. Recent progress on liquid biopsy analysis using surface-enhanced Raman spectroscopy10.7150/thno.29875 ↗
67. Study of chemical enhancement mechanism in non-plasmonic surface enhanced Raman spectroscopy (SERS)10.3389/fchem.2019.00582 ↗
68. V-shaped heterostructure nanocavities array with CM and EM coupled enhancement for ultra-sensitive SERS substrate10.1002/advs.202409838 ↗
69. Defect engineering in semiconductor-based SERS10.1039/d1sc05940h ↗
70. Portable and field-deployed surface plasmon resonance and plasmonic sensors10.1039/d0an00316f ↗
71. Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification10.1016/j.bios.2020.112850 ↗
72. Localized surface plasmon resonance spectroscopy and sensing10.1146/annurev.physchem.58.032806.104607 ↗
73. Highly sensitive, uniform, and reproducible surface-enhanced Raman spectroscopy from hollow Au-Ag alloy nanourchins10.1002/adma.201305106 ↗
74. Three-dimensional nanoframes with dual rims as nanoprobes for biosensing10.1038/s41467-022-32549-w ↗
75. Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors10.1038/s41467-024-50321-0 ↗
76. Ultrasensitive surface-enhanced Raman scattering platform for protein detection via active delivery to nanogaps as a hotspot10.1021/acsnano.4c09578 ↗
77. Surface-enhanced Raman scattering based determination on sulfamethazine using molecularly imprinted polymers decorated with silver nanoparticles10.1007/s00604-023-05744-9 ↗
78. Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer10.1002/advs.202401818 ↗
79. SERS-based droplet microfluidic platform for sensitive and high-throughput detection of cancer exosomes10.1021/acssensors.4c01357 ↗
80. Digital colloid-enhanced Raman spectroscopy by single-molecule counting10.1038/s41586-024-07218-1 ↗
81. Early cancer detection by serum biomolecular fingerprinting spectroscopy with machine learning10.1186/s43593-023-00051-5 ↗
82. Surface-enhanced Raman spectroscopy: Concepts and chemical applications10.1002/anie.201205748 ↗
83. Recent trends in SERS-based plasmonic sensors for disease diagnostics, biomolecules detection, and machine learning techniques10.3390/bios13030328 ↗
84. Metal enhanced fluorescence (MEF) for biosensors: General approaches and a review of recent developments10.1016/j.bios.2018.04.007 ↗
85. Metal-enhanced fluorescence10.1023/a:1016875709579 ↗
86. Metal-enhanced fluorescence10.1039/c3cp90129g ↗
87. Wavelength dependence of metal-enhanced fluorescence10.1021/jp9005668 ↗
88. Wavelength-dependent metal-enhanced fluorescence using synchronous spectral analysis10.1016/j.cplett.2012.11.035 ↗
89. Synthesis of hollow fluorescent polymeric microspheres with movable magnetic cores10.1002/pi.2813 ↗
90. Boosting local field enhancement by on-chip nanofocusing and impedance-matched plasmonic antennas10.1021/acs.nanolett.5b03593 ↗
91. Plasmon-controlled fluorescence: A new paradigm in fluorescence spectroscopy10.1039/b802918k ↗
92. Direct observation of luminescent silver clusters confined in faujasite zeolites10.1021/acsnano.6b02834 ↗
93. Dependence of fluorescence intensity on the spectral overlap between fluorophores and plasmon resonant single silver nanoparticles10.1021/nl062795z ↗
94. Precise in vivo inflammation imaging using in situ responsive cross-linking of glutathione-modified ultra-small NIR-II lanthanide nanoparticles10.1002/ange.201812878 ↗
95. Physical mechanism of concentration-dependent fluorescence resonance energy transfer10.1016/j.saa.2020.118143 ↗
96. FRET as the tool for in vivo nanomedicine tracking10.1016/j.jconrel.2022.06.048 ↗
97. Fluorescence resonance energy transfer measurements in polymer science: A review10.1002/marc.202200421 ↗
98. Calixarene-derived fluorescent probes10.1021/cr068046j ↗
99. FRET microscopy in the living cell: Different approaches, strengths and weaknesses10.1002/bies.201100086 ↗
100. Recent advances in FRET for the study of protein interactions and dynamics10.1016/j.sbi.2017.03.010 ↗