Electrospun Ethyl- p -Methoxycinnamate Loaded CS/PEG/PLA Nanofibers
Source abstract
Abstract
In this study, the characteristic properties and biological activities of the electrospun nanofibers made of polymers including chitosan (CS), polyethylene glycol (PEG), and polylactic acid (PLA) loaded with 15% of a natural anti-inflammatory and analgesic agent, ethyl p-methoxycinnamate (EPMC), were reported. The morphological and chemical characteristics of the fibers were analyzed using a scanning electron microscope and Fourier transform infrared spectra, respectively. The mechanical properties and hydrophilicity of the nanofibers were also investigated. Research on the release of the bioactive compound EPMC from the nanofibers in phosphate-buffered saline medium showed that about 70% of EPMC was released after 24 h. The significant anti-inflammatory effect of the nanofibers was evaluated via inhibition of nitric oxide production in RAW264.7 cells stimulated by lipopolysaccharide with an IC 50 value of 41.05 ± 1.75 µg/mL. Besides, the nanofibers also exhibited anti-bacterial activity and were proved to be safe both in vitro and in vivo. The results suggested that the nanofibers CS/PEG/PLA loaded with ethyl p-methoxycinnamate may be a potential candidate for developing biomedical products related to inflammation.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials · Supercapacitor Materials and Fabrication
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Hanoi University of Pharmacy, Hanoi, Vietnam
Hai Duong Central College of Pharmacy, Hai Duong, Vietnam
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
Phenikaa University Nano Institute (PHENA), Phenikaa University, Hanoi, Vietnam
Center for High Technology Development, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
Central European Institute of Technology (CEITEC), Brno University of Technology, Brno, Czech Republic
References (81)
Show source-provided references
1. Park JS. · ANSN · 2010 · 1 · 043002
2. Cooley JF. Improved methods of and apparatus for electrically separating the relatively volatile liquid component from the component of relatively fixed substances of composite fluids. Patent 6385-19, 1990.
3. 10.1002/admt.20210041010.1002/admt.202100410 ↗
4. 10.1007/s10965-015-0704-810.1007/s10965-015-0704-8 ↗
5. Trang MTT · ANSN · 2012 · 3 · 025014
6. 10.1007/s10856-018-6146-110.1007/s10856-018-6146-1 ↗
7. 10.3390/nano1407064610.3390/nano14070646 ↗
8. 10.1177/2472344424123731610.1177/24723444241237316 ↗
9. 10.1177/0885328224124877810.1177/08853282241248778 ↗
10. 10.1016/j.jallcom.2020.15647110.1016/j.jallcom.2020.156471 ↗
11. 10.1007/s42765-024-00397-610.1007/s42765-024-00397-6 ↗
12. 10.1016/j.cej.2024.15235910.1016/j.cej.2024.152359 ↗
13. 10.1002/wnan.196410.1002/wnan.1964 ↗
14. 10.1016/j.ijpharm.2024.12418010.1016/j.ijpharm.2024.124180 ↗
15. 10.1002/admt.20220172310.1002/admt.202201723 ↗
16. 10.1021/acsbiomaterials.9b0085310.1021/acsbiomaterials.9b00853 ↗
17. 10.3390/pharmaceutics1304055610.3390/pharmaceutics13040556 ↗
18. 10.2174/156720181566618072311432610.2174/1567201815666180723114326 ↗
19. 10.1007/s00289-021-03985-310.1007/s00289-021-03985-3 ↗
20. 10.1039/B9NR00243J10.1039/B9NR00243J ↗
21. 10.1021/acsbiomaterials.4c0002810.1021/acsbiomaterials.4c00028 ↗
22. 10.1021/acsabm.4c0031810.1021/acsabm.4c00318 ↗
23. 10.1007/s42765-021-00129-010.1007/s42765-021-00129-0 ↗
24. 10.1021/acsabm.4c0003810.1021/acsabm.4c00038 ↗
25. 10.1016/j.microc.2024.11032610.1016/j.microc.2024.110326 ↗
26. 10.3390/molecules2912276910.3390/molecules29122769 ↗
27. 10.1021/acsami.1c2413110.1021/acsami.1c24131 ↗
28. 10.1021/acsami.1c2262910.1021/acsami.1c22629 ↗
29. 10.1002/mabi.20130056110.1002/mabi.201300561 ↗
30. 10.1016/j.colsurfb.2018.05.01110.1016/j.colsurfb.2018.05.011 ↗
31. 10.1016/j.nantod.2024.10216110.1016/j.nantod.2024.102161 ↗
32. 10.1021/acsanm.4c0063110.1021/acsanm.4c00631 ↗
33. 10.1016/j.jconrel.2014.04.01810.1016/j.jconrel.2014.04.018 ↗
34. 10.1088/0957-4484/20/5/05510410.1088/0957-4484/20/5/055104 ↗
35. 10.4028/www.scientific.net/AMM.662.2910.4028/www.scientific.net/AMM.662.29 ↗
36. 10.1021/mp500391y10.1021/mp500391y ↗
37. 10.1016/j.ijpharm.2015.04.04410.1016/j.ijpharm.2015.04.044 ↗
38. 10.1016/j.msea.2007.01.03910.1016/j.msea.2007.01.039 ↗
39. 10.1016/j.matlet.2012.02.09310.1016/j.matlet.2012.02.093 ↗
40. 10.3109/21691401.2014.92400710.3109/21691401.2014.924007 ↗
41. 10.1080/0022234060076983210.1080/00222340600769832 ↗
42. 10.1016/j.jconrel.2005.07.02110.1016/j.jconrel.2005.07.021 ↗
43. 10.1007/s10118-014-1491-010.1007/s10118-014-1491-0 ↗
44. 10.1016/j.ajps.2017.08.00810.1016/j.ajps.2017.08.008 ↗
45. 10.1021/acs.chemrev.8b0059310.1021/acs.chemrev.8b00593 ↗
46. Hasnain MS, Beg S, Nayak AK. Chitosan in drug delivery. Cambridge: Academic Press, 2021, pp. 4–11.
47. 10.3390/polym1319325610.3390/polym13193256 ↗
48. 10.1007/s12221-016-5800-910.1007/s12221-016-5800-9 ↗
49. 10.3390/polym1202029810.3390/polym12020298 ↗
50. 10.1515/gps-2016-006010.1515/gps-2016-0060 ↗
51. 10.34172/jhp.2021.3210.34172/jhp.2021.32 ↗
52. Loi DT. Vietnamese medicinal plants and herbs. Hanoi: Medical Publishing House, 2004, pp. 365–366 (in Vietnamese).
53. Shetu HJ · IJRPS · 2018 · 3 · 32
54. 10.3390/molecules1707872010.3390/molecules17078720 ↗
55. 10.6061/clinics/2014(02)1010.6061/clinics/2014(02)10 ↗
56. Keller CL · Cureus · 2024 · 16
57. 10.1007/978-1-4939-6976-0_2110.1007/978-1-4939-6976-0_21 ↗
58. 10.1016/j.semarthrit.2008.08.00110.1016/j.semarthrit.2008.08.001 ↗
59. 10.1016/S0002-9343(99)00365-410.1016/S0002-9343(99)00365-4 ↗
60. 10.1016/j.msec.2021.11258510.1016/j.msec.2021.112585 ↗
61. 10.1016/j.ijbiomac.2023.12919510.1016/j.ijbiomac.2023.129195 ↗
62. Van MJ · 2011 · 237
63. 10.1007/978-94-011-4810-8_410.1007/978-94-011-4810-8_4 ↗
64. McKane L · 1996 · 97
65. 10.1093/jnci/82.13.110710.1093/jnci/82.13.1107 ↗
66. Organisation for Economic Co-operation and Development (OECD) · 2001
67. Vietnam Ministry of Health. Guidelines for preclinical and clinical trials of traditional medicines, 2015 (in Vietnamese, issued with Decision No. 141/QD-K2DT dated October 27, 2015).
68. Lillo L · Rev Latinoam Quím · 2014 · 42 · 70
69. 10.1016/j.compositesb.2011.04.02410.1016/j.compositesb.2011.04.024 ↗
70. 10.3390/membranes1211115810.3390/membranes12111158 ↗
71. 10.1021/acsomega.9b0261610.1021/acsomega.9b02616 ↗
72. Banik I. Electrospinning nanofibers for controlled drug release. Master's Thesis, University of Texas – Pan American, Edinburg, TX, 2013.
73. 10.1155/2022/519016310.1155/2022/5190163 ↗
74. 10.1039/C5RA18535A10.1039/C5RA18535A ↗
75. 10.1016/j.bej.2015.11.00110.1016/j.bej.2015.11.001 ↗
76. 10.1016/j.ijbiomac.2017.07.02110.1016/j.ijbiomac.2017.07.021 ↗
77. 10.1039/D0NJ01594F10.1039/D0NJ01594F ↗
78. 10.1007/s10787-007-0013-x10.1007/s10787-007-0013-x ↗
79. 10.1016/j.jep.2008.05.03810.1016/j.jep.2008.05.038 ↗
80. 10.1016/S0895-3988(10)60056-610.1016/S0895-3988(10)60056-6 ↗
81. Mufidah M · Trad Med J · 2013 · 18 · 35