Biodegradable composites based on nanocrystalline calcium phosphate and bioresorbable polymers

Nanocrystalline calcium phosphates (NC CP) are suitable for the synthesis of CP/bioresorbable polymer composite biomaterials for the application in bone engineering. There are different forms of NC CP/bioresorbable polymers composite biomaterials. Calcium phosphate was synthesised in highly NC form. A NC calcium phosphate/poly-DL-lactide-co-glycolide (CP/DLPLG) composite biomaterial in filler forms was synthesised in the shape of spherical granules (150–200 mm in diameter) and nanoparticles (30–40 nm in diameter). Each CP granule or nanoparticle was coated with amorphous DLPLG polymer. Using NC and nanosized CP/DLPLG composite materials, an injectable composite biomaterial was prepared. By hot pressing of highly porous NC CP/bioresorbable polymer composite biomaterials at the polymer's melting temperature, blocks were obtained with relatively uniform distribution of phases. Designing of the properties of CP/bioresorbable polymers composite biomaterial block was provided by combining high pressure, temperature and time.