DataVXAdvances in Applied CeramicsPaper
journal article·2021-11-17

In vivo toxicity and biodegradation studies in mimicked biological media of bare and functionalised haematite nanoparticles

Kanwal Akhtar, Naveed Akhtar Shad, Muhammad Munir Sajid, Yasir Javed, Faqir Muhammad, Bushra Akhtar, M. Irfan Hussain, Ali Sharif, Wasim Abbas, Anam Munawar

Advances in Applied Ceramics· Volume 120· Issue 5-8
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Source abstract

Abstract

Bare and functionalised haematite nanoparticles (NPs) are synthesised through the co-precipitation method and characterised using XRD, SEM, TEM, EDX, FTIR, and VSM. XRD confirmed the rhombohedral-based hexagonal structure of Fe2O3, while, TEM and SEM showed the formation of lamellar-shaped NPs with the grain size varied from 22 to 80 nm. VSM presented soft ferromagnetic behaviour. From in vivo evaluations, changes in serum levels are analysed at different days of study after administration of bare and coated NPs through the intraperitoneal route of administration in albino rats. Toxicity parameters revealed a transient increase at day 1 but a gradual decrease thereafter. For biodegradation studies, NPs exposure in lysosomal-like medium showed insignificant changes in the absorbance spectrum for a short interval of time, however, dynamical degradation effects were observed on Day 8. Apoferritin studies disclose the growth of absorbance near 260 nm, which reveals progressive and partially filled proteins with iron ions.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Iron Metabolism and Disorders · Iron oxide chemistry and applications · Nanoparticles: synthesis and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, University of Agriculture, Faisalabad, Pakistan

National Institute of Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan

Henan Key Laboratory of Photovoltaic Materials, School of Physics, Henan Normal University, Xinxiang, People’s Republic of China

Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan

Institute of Materials Science and Advanced Ceramics, University of Science and Technology Beijing, Beijing, People’s Republic of China

Institute of Pharmacy, Lahore College for Women University, Lahore, Pakistan

Division of Health Biotechnology, National Institute for Biotechnology & Genetic Engineering (NIBGE), Faisalabad, Pakistan

Department of Biotechnology, Qarshi University, Lahore, Pakistan

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