Optimisation of process parameters for fabrication of nanocrystalline TiO 2 –hydoxyapatite based scaffold using response surface methodology
Source abstract
Abstract
The present study focuses on the application of central composite design of response surface methodology for optimisation of process parameters to develop a hybrid mechanically stable biocompatible porous scaffold. The scaffolds are developed by varying the composition of fish scale derived HAp and nanocrystalline TiO 2 powders. The effects of sintering temperature, dwell time on the porosity and compressive strength of the scaffolds are investigated. Various diagnostic tools (e.g. thermogravimetric/differential thermal analysis, Fourier transform infrared spectroscopy, X-ray diffraction and field emission scanning electron microscopy /energy dispersive X-ray spectroscopy) are used for composition, phase conformity and microstructure evaluation of green as well as sintered materials. The desirability function optimisation study reveals that at 60∶40 (TiO 2 ∶HAp) concentration with sintering temperature of 1100°C for 90 min provides the maximum compressive strength of 78·5 MPa and maximum porosity of 33·5%.
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Research context
OpenAlex topics: Additive Manufacturing and 3D Printing Technologies · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Centre for Advanced Materials Processing CSIR-Central Mechanical Engineering Research Institute, Mahatma Gandhi Avenue, Durgapur 713 209, India
Department of Biotechnology National Institute of Technology, Durgapur 713 209, India
References (26)
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