Morphological and antibacterial effects of silver, magnesium, silicon and strontium modified calcium phosphate bone cements prepared by the sol–gel method

In this study, the sol–gel method was used to add MgO and SrBr2 to biografts containing Ca(NO3)2·4H2O, SiO2, P2O5, H3BO3 and AgNO3. In addition, urea (15–35% by weight) was added to these biografts in different ratios. FTIR, XRD and SEM–EDX analyses were performed in order to observe the morphological effects. Antibacterial tests were carried out using S.aureus and E.coli bacteria. As a result of FTIR analysis, it was observed that H–OH, CO3−, CO33−, PO43−, Si–O and Si–O–Si compound structures were formed in the biografts. XRD analysis was found that HA (Hydroxyapatite), β-TCP, CaSiO3, CaMgSi2O6, Ca3MgSi2O8, CaMgSi2O6 and Mg17Sr2 compound structures were formed. Antibacterial analysis with E. coli showed that all biografts except the one that contained the highest amount of urea (35% by weight) yielded colony counting values close to the negative control. For S. aureus, the opposite result was observed.