DataVXAdvanced Sustainable SystemsPaper
journal article·2026-04Open access

Challenges and Future Directions in Assessing the Quality and Completeness of Advanced Materials Safety Data for Re‐Usability: A Position Paper From the Nanosafety Community

Verónica I. Dumit, Irini Furxhi, Penny Nymark, Antreas Afantitis, Ammar Ammar, Monica J. B. Amorim, Dalila Antunes, Svetlana Avramova, Chiara L. Battistelli, Gianpietro Basei, Cecilia Bossa, Emil Cimpan, Mihaela Roxana Cimpan, Dmitri Ciornii, Anna Costa, Camilla Delpivo, Maria Dusinska, Ana Sofia Fonseca, Steffi Friedrichs, Vasile‐Dan Hodoroaba, Danail Hristozov, Panagiotis Isigonis, Nina Jeliazkova, Nikolay Kochev, Eva Kranjc, Dieter Maier, Georgia Melagraki, Anastasios G. Papadiamantis, Tomasz Puzyn, Hubert Rauscher, Katie Reilly, Araceli Sánchez Jiménez, Janeck J. Scott‐Fordsmand, Neeraj Shandilya, Hyun Kil Shin, Gergana Tancheva, Jeaphianne P. M. van Rijn, Egon L. Willighagen, Ewelina Wyrzykowska, Martine I. Bakker, Damjana Drobne, Thomas E. Exner, Martin Himly, Iseult Lynch

Advanced Sustainable Systems· Volume 10· Issue 4
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Source abstract

Abstract

Abstract Ensuring data quality, completeness, and interoperability is crucial for progressing safety research, Safe‐and‐Sustainable‐by‐Design approaches, and regulatory approval of nanoscale and advanced materials. While the FAIR (Findable, Accessible, Interoperable, and Re‐usable) principles aim to promote data re‐use, they do not address data quality, essential for data re‐use for advancing sustainable and safe innovation. Effective quality assurance procedures require (meta)data to conform to community‐agreed standards. Nanosafety data offer a key reference point for developing best practices in data management for advanced materials, as their large‐scale generation coincided with the emergence of dedicated data quality criteria and concepts such as FAIR data. This work highlights frameworks, methodologies, and tools that address the challenges associated with the multidisciplinary nature of nanomaterial safety data. Existing approaches to evaluating the reliability, relevance, and completeness of data are considered in light of their potential for integration into harmonized standards and adaptation to advance material requirements. The goal here is to emphasize the importance of automated tools to reduce manual labor in making (meta)data FAIR, enabling trusted data re‐use and fostering safer, more sustainable innovation of advanced materials. Awareness and prioritization of these challenges are critical for building robust data infrastructures.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Research Data Management Practices · Scientific Computing and Data Management · Analytical chemistry methods development

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Product Safety German Federal Institute for Risk Assessment (BfR) Max‐Dohrn‐Str. 8–10 10589 Berlin Germany

CNR‐ISSMC (Former ISTEC), National Research Council of Italy‐Institute of Science Technology and Sustainability for Ceramics Via Granarolo, 64 Faenza 48018 Italy

Institute of Environmental Medicine, Karolinska Institutet Nobels väg 6 Stockholm 17177 Sweden

Nanoinformatics Department NovaMechanics Ltd. Nicosia Cyprus

Department of Translational Genomics NUTRIM, Maastricht University Universiteitssingel 60, 6229 ER Maastricht The Netherlands

Department of Biology & CESAM University of Aveiro, Campus de Santiago Aveiro 3810193 Portugal

Factor Social Lda. R. Laura Alves, 12 6º andar Lisbon 1050138 Portugal

Ideaconsult Ltd. Sofia Bulgaria

Environment and Health Department Istituto Superiore di Sanità Viale Regina Elena, 299 Roma RM 00161 Italy

Officinae Bio Srl Via Giuseppe Verdi, 32 Venice 30172 Italy

Department of Computer Science Electrical Engineering and Mathematical Sciences Western Norway University of Applied Sciences Allégaten 41 Bergen 5007 Norway

Department of Clinical Dentistry University of Bergen Årstadveien 19 Bergen 5009 Norway

Federal Institute for Materials Research and Testing (BAM) Division 6.1 Surface and Thin Film Analysis Unter den Eichen 87 12205 Berlin Germany

LEITAT Technological Center Carrer de la Innovació, 2 Terrassa Barcelona 08225 Spain

Health Effects Laboratory, Department of Environmental Chemistry & Health Effects The Climate and Environmental Research Institute NILU Instituttveien 18 Kjeller 2007 Norway

National Research Centre for the Working Environment (NFA) Lersø Parkallé 105 Copenhagen DK‐2100 Denmark

AcumenIST SRL Rue Fétis 19 Etterbeek 1040 Belgium

East European Research and Innovation Enterprise Ltd. Pette Kyosheta, ul. “Otets Paisiy” 46 Sofia 1303 Bulgaria

Luxembourg Institute of Science and Technology (LIST) 5 Av. des Hauts‐Fourneaux Esch‐Belval Esch‐sur‐Alzette 4362 Luxembourg

Department of Analytical Chemistry and Computer Chemistry Faculty of Chemistry University of Plovdiv, TsentarPlovdiv Center King Asen St 24 Plovdiv 4000 Bulgaria

Department of Biology, Biotechnical Faculty University of Ljubljana Jamnikarjeva 101 Ljubljana 1000 Slovenia

Labvantage – Biomax GmbH Robert‐Koch‐Straße 2 82152 Planegg Germany

Division of Physical Sciences and Applications Hellenic Military Academy Leoforos Eyelpidon (Varis – Koropiou) Avenue Vari 16673 Greece

School of Geography, Earth and Environmental Sciences University of Birmingham Edgbaston Birmingham B15 2TT UK

Entelos Institute Medousis 16 Larnaca 6059 Cyprus

References (100+)

Show source-provided references
1. 10.1016/j.impact.2017.09.00110.1016/j.impact.2017.09.001 ↗
2. 10.1038/sdata.2016.1810.1038/sdata.2016.18 ↗
3. Regulation (EU) 2023/2854 of the European Parliament and of the Council of 13 December 2023 on harmonised rules on fair access to and use of data and amending Regulation (EU) 2017/2394 and Directive (EU) 2020/1828. Data Act Official Journal of the European Union L 2023/2854 22.12.2023 European Parliament and Council Brussels Belgium2023 pp.1–71.
4. 10.1080/1062936X.2012.66482510.1080/1062936X.2012.664825 ↗
5. Communication from the Commission to the European Parliament the Council the European Economic and Social Committee and the Committee of the Regions: A Strategy for ICT R&D and Innovation in Europe: Raising the Game Vol.116 Commission of the European Communities Brussels Belgium2009.
6. Regulation (EU) 2022/868 of the European Parliament and of the Council of 30 May 2022 on European data governance and amending Regulation (EU) 2018/1724 (Data Governance Act) J. Eur. Union L 152 3.6.2022 European Parliament and Council Brussels Belgium2022 pp.1–44
7. 10.1038/nnano.2017.16210.1038/nnano.2017.162 ↗
8. 10.1016/j.csbj.2024.05.01810.1016/j.csbj.2024.05.018 ↗
9. 10.1039/C5NR08944A10.1039/C5NR08944A ↗
10. 10.1016/j.impact.2023.10047510.1016/j.impact.2023.100475 ↗
11. 10.3389/ftox.2023.131998510.3389/ftox.2023.1319985 ↗
12. https://www.oecd.org/en/topics/sub‐issues/testing‐of‐chemicals/mutual‐acceptance‐of‐data‐system.html(accessed: March 2025).
13. OECD. Mutual Acceptance of Data (MAD) System. https://www.oecd.org/en/topics/sub‐issues/testing‐of‐chemicals/mutual‐acceptance‐of‐data‐system.html(accessed: December 2024).
14. https://www.oecd.org/en/topics/sub‐issues/testing‐of‐chemicals/test‐guidelines.html(accessed: March 2025).
15. https://www.oecd.org/en/topics/sub‐issues/testing‐of‐chemicals/good‐laboratory‐practice‐and‐compliance‐monitoring.html(accessed: March 2025).
16. Caldeira C. · 2022
17. https://riskgone.nilu.no/(accessed: March 2025).
18. https://nanorigo.eu/(accessed: March 2025).
19. https://www.gov4nano.eu/(accessed: March 2025).
20. https://www.nanocommons.eu/(accessed: March 2025).
21. https://www.harmless‐project.eu/(accessed: March 2025).
22. https://polyrisk.science/(accessed: March 2025).
23. https://compsafenano.eu/(accessed: March 2025).
24. https://worldfair‐project.eu/(accessed: March 2025).
25. https://www.eu‐parc.eu/(accessed: March 2025).
26. https://macrame‐project.eu/(accessed: March 2025).
27. https://pink‐project.eu/.
28. https://accordsproject.com/(accessed: March 2025).
29. https://www.h2020charisma.eu/(accessed: March 2025).
30. https://www.sabydoma.eu/(accessed: March 2025).
31. https://www.h2020gracious.eu/(accessed: March 2025).
32. https://nanosolveit.eu/(accessed: March 2025).
33. 10.1016/j.impact.2024.10051310.1016/j.impact.2024.100513 ↗
34. 10.1002/smll.20200330310.1002/smll.202003303 ↗
35. 10.1002/gch2.20220021110.1002/gch2.202200211 ↗
36. 10.1016/j.nantod.2023.10192310.1016/j.nantod.2023.101923 ↗
37. 10.1038/s41596-024-00993-110.1038/s41596-024-00993-1 ↗
38. D. C.Berrios A.Beheshti S. V.Costes presented atAMIA Annual Symp. Proc. San Francisco California 2018 232.
39. 10.1002/smll.20200562210.1002/smll.202005622 ↗
40. 10.1016/j.tips.2018.12.00110.1016/j.tips.2018.12.001 ↗
41. 10.1016/j.yrtph.2021.10502010.1016/j.yrtph.2021.105020 ↗
42. 10.1038/s41565-021-00911-610.1038/s41565-021-00911-6 ↗
43. 10.1038/s41565-021-01049-110.1038/s41565-021-01049-1 ↗
44. 10.1038/s41565-021-01050-810.1038/s41565-021-01050-8 ↗
45. 10.1080/17435390.2024.236800510.1080/17435390.2024.2368005 ↗
46. 10.1039/C7EN01127J10.1039/C7EN01127J ↗
47. OECD. Test no. 202: Daphnia sp. acute immobilisation test OECD Paris France2004.
48. 10.1039/C8EN00061A10.1039/C8EN00061A ↗
49. https://www.kitox.re.kr/nanotoxradar/(accessed: March 2025).
50. 10.1016/j.impact.2021.10029810.1016/j.impact.2021.100298 ↗
51. 10.1016/j.yrtph.2017.09.02010.1016/j.yrtph.2017.09.020 ↗
52. 10.1016/j.nantod.2021.10124210.1016/j.nantod.2021.101242 ↗
53. 10.1038/ng1201-36510.1038/ng1201-365 ↗
54. Brazma A. · Zenodo · 2012
55. 10.1038/nbt1206-147110.1038/nbt1206-1471 ↗
56. 10.1038/nbt132910.1038/nbt1329 ↗
57. 10.1016/j.yrtph.2017.11.00110.1016/j.yrtph.2017.11.001 ↗
58. 10.1016/j.jprot.2013.02.02610.1016/j.jprot.2013.02.026 ↗
59. 10.1038/s41467-019-10900-y10.1038/s41467-019-10900-y ↗
60. 10.1093/biostatistics/kxr03110.1093/biostatistics/kxr031 ↗
61. 10.1177/146906672091844610.1177/1469066720918446 ↗
62. 10.1016/j.yrtph.2015.08.00610.1016/j.yrtph.2015.08.006 ↗
63. 10.1016/j.tiv.2018.06.00910.1016/j.tiv.2018.06.009 ↗
64. 10.1038/s41597-021-00808-y10.1038/s41597-021-00808-y ↗
65. 10.1002/etc.595910.1002/etc.5959 ↗
66. 10.1002/smll.20200030110.1002/smll.202000301 ↗
67. 10.1016/j.yrtph.2019.02.00810.1016/j.yrtph.2019.02.008 ↗
68. https://www.proteomicsdb.org/(accessed: March 2025).
69. https://www.ebi.ac.uk/metabolights/(accessed: March 2025).
70. https://search.data.enanomapper.net/about/omics/(accessed: March 2025).
71. https://db.nanopharos.eu/Queries/Datasets.zul?datasetID=np2(accessed: March 2025).
72. 10.1021/acsanm.3c0017310.1021/acsanm.3c00173 ↗
73. 10.3390/nano1103063910.3390/nano11030639 ↗
74. 10.1016/B978-0-12-814182-3.00026-210.1016/B978-0-12-814182-3.00026-2 ↗
75. https://www.iso.org/committee/54674.html(accessed: March 2025).
76. 10.1002/sia.74012021910.1002/sia.740120219 ↗
77. 10.1073/pnas.060858210410.1073/pnas.0608582104 ↗
78. 10.1038/s41596-024-01009-810.1038/s41596-024-01009-8 ↗
79. 10.3389/fphy.2023.123387910.3389/fphy.2023.1233879 ↗
80. 10.1039/D3SU00148B10.1039/D3SU00148B ↗
81. 10.3390/nano1010203310.3390/nano10102033 ↗
82. https://isa‐tools.org/index.html(accessed: March 2025).
83. 10.1186/1472-6750-13-210.1186/1472-6750-13-2 ↗
84. 10.3390/nano1107181810.3390/nano11071818 ↗
85. 10.3390/nano1106152010.3390/nano11061520 ↗
86. 10.3390/coatings1112148610.3390/coatings11121486 ↗
87. 10.3390/nano1010190810.3390/nano10101908 ↗
88. https://isa‐specs.readthedocs.io/en/latest/isajson.html(accessed: March 2025).
89. Joint Research Centre & Totaro S. NANoREG data logging templates for the environmental health and safety assessment of nanomaterials Publications Office of the European Union Luxembourg2017.
90. https://publications.jrc.ec.europa.eu/repository/handle/JRC103178(accessed: March 2025).
91. GRACIOUS data logging templates for the environmental health and safety assessment of nanomaterials European Commission & Joint Research Centre Brussels Belgium2019.
92. https://enanomapper.adma.ai/templates/(accessed: March 2025).
93. 10.1038/s41597-024-03324-x10.1038/s41597-024-03324-x ↗
94. 10.1016/j.csbj.2024.10.01810.1016/j.csbj.2024.10.018 ↗
95. (Q)SAR Assessment Framework: Guidance for the regulatory assessment of (Quantitative) Structure Activity Relationship models and predictions Second Edition OECD Series on Testing and Assessment No. 405 OECD Paris2024.
96. Application of systematic review in TSCA risk evaluations US EPA Washington DC USA2018.
97. Hardy A. · Efsa Journal · 2017 · 15
98. EFSA Scientific C. · Efsa Journal · 2018 · 16
99. Data Quality Framework for EU medicines regulation. Official Journal of the European Union L 2023/2854 European Medicines Agency Amsterdam The Netherlands2023 pp1‐71
100. 10.1006/rtph.1996.107610.1006/rtph.1996.1076 ↗