Development and Characterization of Naproxen-Loaded Poly(vinyl alcohol) Nanofibers Crosslinked with Polycarboxylic Acids
Source abstract
Abstract
Poly(vinyl alcohol) (PVA) hydrogel nanofibers are a potential candidate for textile-based drug-release applications. Polycarboxylic acids 1,2,3,4-butanetetracarboxylic acid (BTCA) and citric acid (CA) are low-cost alternatives reported to easily crosslink electrospun PVA hydrogel. These can be directly added into the spinning solutions. One of the most efficient non-steroidal anti-inflammatory drugs (NSAIDs), Naproxen (NAP), was selected as a model drug for this study. The release mechanisms of drug-loaded electrospun PVA nanofibers are based on the diffusion of the drugs through the swollen PVA fibrous matrix and the release due to partial dissolution of the matrix. Control over drug-release characteristics can be provided through partial crosslinking of the PVA fibrous matrix.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials · Conducting polymers and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Pamukkale University
Ege University
References (41)
Show source-provided references
1. 10.1142/9789812567611_000210.1142/9789812567611_0002 ↗
2. 10.1016/S0266-3538(03)00178-710.1016/S0266-3538(03)00178-7 ↗
3. 10.1080/0098644100362599710.1080/00986441003625997 ↗
4. 10.1016/j.biomaterials.2008.01.01110.1016/j.biomaterials.2008.01.011 ↗
5. 10.1080/1083745080240942010.1080/10837450802409420 ↗
6. 10.1088/0957-4484/17/9/04110.1088/0957-4484/17/9/041 ↗
7. 10.1016/j.msea.2007.01.03910.1016/j.msea.2007.01.039 ↗
8. 10.1016/S0167-577X(03)00532-910.1016/S0167-577X(03)00532-9 ↗
9. 10.1002/app.2060210.1002/app.20602 ↗
10. 10.1088/0957-4484/18/17/17510210.1088/0957-4484/18/17/175102 ↗
11. 10.1088/1758-5082/4/2/02500210.1088/1758-5082/4/2/025002 ↗
12. 10.1002/app.3903610.1002/app.39036 ↗
13. 10.1016/j.carbpol.2008.04.04510.1016/j.carbpol.2008.04.045 ↗
14. 10.1016/j.tibtech.2015.03.00810.1016/j.tibtech.2015.03.008 ↗
15. Glutaraldehyde, CAS No: 111-30-8; Organisation for Economic Co-operation and Development SIDS; UNEP Publications: Geneva, Switzerland, http://webnet.oecd.org/Hpv/UI/handler.axd?id=da11e1ee-332f-4be5-96ef-d1d4f81d3d57 (accessed April 2017).
16. Glyoxal, CAS No: 107-22-2; Organisation for Economic Co-operation and Development SIDS; UNEP Publications: Geneva, Switzerland, http://www.inchem.org/documents/sids/sids/107222.pdf (accessed April 2017).
17. 10.1016/j.carbpol.2007.05.02810.1016/j.carbpol.2007.05.028 ↗
18. Welch C.M. · Textile Chemist and Colorist · 1997 · 29 · 22
19. 10.1080/1556365080245925410.1080/15563650802459254 ↗
20. Shepard T.H., Lemire R.J. Catalog of Teratogenic Agents; JHU Press: Baltimore, MD, USA, 2004; p 417.
21. 10.1016/S0890-6238(01)00142-310.1016/S0890-6238(01)00142-3 ↗
22. 10.1016/j.carbpol.2011.06.08610.1016/j.carbpol.2011.06.086 ↗
23. Citric Acid, CAS No: 77–92–9; Organisation for Economic Cooperation and Development SIDS; UNEP Publications: Geneva, Switzerland, http://www.inchem.org/documents/sids/sids/77929.pdf (accessed April 2017).
24. 10.1002/adma.20030626410.1002/adma.200306264 ↗
25. 10.1023/A:102302200833710.1023/A:1023022008337 ↗
26. 10.1007/s10856-010-4100-y10.1007/s10856-010-4100-y ↗
27. https://www.kruss.de/products/tensiometers/force-tensiometer-k20/
28. 10.1016/j.memsci.2008.10.01710.1016/j.memsci.2008.10.017 ↗
29. 10.1016/j.addr.2008.08.00210.1016/j.addr.2008.08.002 ↗
30. 10.1016/j.jssc.2004.08.00610.1016/j.jssc.2004.08.006 ↗
31. 10.1007/s10847-012-0241-610.1007/s10847-012-0241-6 ↗
32. 10.1016/j.carbpol.2011.10.02410.1016/j.carbpol.2011.10.024 ↗
33. 10.1016/j.jssc.2004.03.04110.1016/j.jssc.2004.03.041 ↗
34. 10.1016/S0032-3861(00)00287-110.1016/S0032-3861(00)00287-1 ↗
35. 10.1007/s10965-005-9023-910.1007/s10965-005-9023-9 ↗
36. 10.1016/S0141-3910(01)00083-010.1016/S0141-3910(01)00083-0 ↗
37. 10.1002/polb.1019110.1002/polb.10191 ↗
38. 10.1016/j.powtec.2013.05.04410.1016/j.powtec.2013.05.044 ↗
39. 10.1016/j.memsci.2004.04.01010.1016/j.memsci.2004.04.010 ↗
40. 10.1016/j.msec.2016.04.00510.1016/j.msec.2016.04.005 ↗
41. Bagchi A. · Journal of Fibre & Textile Research · 2002 · 27 · 166